KEGG   NETWORK: N01723
Entry
N01723                      Network                                
Name
NAD biosynthesis
Definition
Trp -- (TDO2,IDO1/2) >> AFMID -> Kyn -- KMO >> KYNU >> HAAO >> QPRT >> NMNAT >> NADSYN1 -> NAD+
  Expanded
C00078 -- (6999,169355,3620) >> 125061 -> C00328 -- 8564 >> 8942 >> 23498 >> 23475 >> (23057,349565,64802) >> 55191 -> C00003
Class
nt06036 Lysine degradation
Type
Reference
Pathway
hsa00380  Tryptophan metabolism
hsa00760  Nicotinate and nicotinamide metabolism
Gene
6999  TDO2; tryptophan 2,3-dioxygenase
169355  IDO2; indoleamine 2,3-dioxygenase 2
3620  IDO1; indoleamine 2,3-dioxygenase 1
125061  AFMID; arylformamidase
8564  KMO; kynurenine 3-monooxygenase
8942  KYNU; kynureninase
23498  HAAO; 3-hydroxyanthranilate 3,4-dioxygenase
23475  QPRT; quinolinate phosphoribosyltransferase
23057  NMNAT2; nicotinamide nucleotide adenylyltransferase 2
349565  NMNAT3; nicotinamide nucleotide adenylyltransferase 3
64802  NMNAT1; nicotinamide nucleotide adenylyltransferase 1
55191  NADSYN1; NAD synthetase 1
Metabolite
C00078  L-Tryptophan
C00328  L-Kynurenine
C00003  NAD+
Reference
PMID:31954874
  Authors
Castro-Portuguez R, Sutphin GL
  Title
Kynurenine pathway, NAD(+) synthesis, and mitochondrial function: Targeting tryptophan metabolism to promote longevity and healthspan.
  Journal
Exp Gerontol 132:110841 (2020)
DOI:10.1016/j.exger.2020.110841
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