KEGG   NETWORK: N01762
Entry
N01762                      Network                                
Name
MERTK-mediated recognition and engulfment
Definition
PtdSer(outer) -> (GAS6,PROS1,TIM4) -> MERTK -> FAK
  Expanded
C02737 -> (2621,5627,91937) -> 10461 -> 5747
Class
nt06535 Efferocytosis
Type
Reference
Pathway
hsa04148  Efferocytosis
Gene
2621  GAS6; growth arrest specific 6
5627  PROS1; protein S
91937  TIMD4; T cell immunoglobulin and mucin domain containing 4
10461  MERTK; MER proto-oncogene, tyrosine kinase
5747  PTK2; protein tyrosine kinase 2
Metabolite
C02737  Phosphatidylserine
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:30846565
  Authors
Nishi C, Yanagihashi Y, Segawa K, Nagata S
  Title
MERTK tyrosine kinase receptor together with TIM4 phosphatidylserine receptor mediates distinct signal transduction pathways for efferocytosis and cell  proliferation.
  Journal
J Biol Chem 294:7221-7230 (2019)
DOI:10.1074/jbc.RA118.006628
Reference
PMID:15673687
  Authors
Wu Y, Singh S, Georgescu MM, Birge RB
  Title
A role for Mer tyrosine kinase in alphavbeta5 integrin-mediated phagocytosis of apoptotic cells.
  Journal
J Cell Sci 118:539-53 (2005)
DOI:10.1242/jcs.01632
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