KEGG   NETWORK: N01776
Entry
N01776                      Network                                
Name
CaMK2-p38-MK2-ALOX5 pathway
Definition
CAMK2 -> p38 -> MK2 -- ALOX5(cyto) -> ALOX5(nuclear)
  Expanded
(815,816,817,818) -> (1432,5600,5603,6300) -> 9261 -- 240 -> 240
Class
nt06535 Efferocytosis
Type
Reference
Pathway
hsa04148 Efferocytosis   
Gene
815  CAMK2A; calcium/calmodulin dependent protein kinase II alpha
816  CAMK2B; calcium/calmodulin dependent protein kinase II beta
817  CAMK2D; calcium/calmodulin dependent protein kinase II delta
818  CAMK2G; calcium/calmodulin dependent protein kinase II gamma
1432  MAPK14; mitogen-activated protein kinase 14
5600  MAPK11; mitogen-activated protein kinase 11
5603  MAPK13; mitogen-activated protein kinase 13
6300  MAPK12; mitogen-activated protein kinase 12
9261  MAPKAPK2; MAPK activated protein kinase 2
240  ALOX5; arachidonate 5-lipoxygenase
Reference
  Authors
Cai B, Kasikara C, Doran AC, Ramakrishnan R, Birge RB, Tabas I
  Title
MerTK signaling in macrophages promotes the synthesis of inflammation resolution mediators by suppressing CaMKII activity.
  Journal
Sci Signal 11:11/549/eaar3721 (2018)
DOI:10.1126/scisignal.aar3721
Reference
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
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