KEGG   Homo sapiens (human): 815
Entry
815               CDS       T01001                                 
Symbol
CAMK2A, CAMKA, CaMKIINalpha, CaMKIIalpha, MRD53, MRT63
Name
(RefSeq) calcium/calmodulin dependent protein kinase II alpha
  KO
K04515  calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04012  ErbB signaling pathway
hsa04020  Calcium signaling pathway
hsa04024  cAMP signaling pathway
hsa04066  HIF-1 signaling pathway
hsa04114  Oocyte meiosis
hsa04148  Efferocytosis
hsa04217  Necroptosis
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04310  Wnt signaling pathway
hsa04360  Axon guidance
hsa04713  Circadian entrainment
hsa04720  Long-term potentiation
hsa04722  Neurotrophin signaling pathway
hsa04725  Cholinergic synapse
hsa04728  Dopaminergic synapse
hsa04740  Olfactory transduction
hsa04750  Inflammatory mediator regulation of TRP channels
hsa04911  Insulin secretion
hsa04912  GnRH signaling pathway
hsa04916  Melanogenesis
hsa04921  Oxytocin signaling pathway
hsa04922  Glucagon signaling pathway
hsa04925  Aldosterone synthesis and secretion
hsa04934  Cushing syndrome
hsa04971  Gastric acid secretion
hsa05012  Parkinson disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05031  Amphetamine addiction
hsa05152  Tuberculosis
hsa05200  Pathways in cancer
hsa05205  Proteoglycans in cancer
hsa05214  Glioma
hsa05415  Diabetic cardiomyopathy
hsa05417  Lipid and atherosclerosis
Network
nt06220  Calcium signaling (cancer)
nt06273  Glioma
nt06316  Renin-angiotensin-aldosterone signaling
nt06528  Calcium signaling
nt06535  Efferocytosis
nt06541  Cytoskeleton in neurons
  Element
N00026  EGF-EGFR-PLCG-CAMK signaling pathway
N00027  Amplified EGFR to PLCG-CAMK signaling pathway
N00028  PDGF-PDGFR-PLCG-CAMK signaling pathway
N00029  Amplified PDGFR to PLCG-CAMK signaling pathway
N00301  Angiotensin-aldosterone signaling pathway
N00302  Mutation-activated CACNA1D/H to angiotensin-aldosterone signaling pathway
N00303  Mutation-activated KCNJ5 to angiotensin-aldosterone signaling pathway
N00304  Mutation-inactivated ATP1A1 to angiotensin-aldosterone signaling pathway
N00305  Mutation-inactivated ATP2B3 to angiotensin-aldosterone signaling pathway
N01648  Ca2+/CAM-CAMK signaling pathway
N01775  Inactivation of CaMKII by inducing SERCA2
N01776  CaMK2-p38-MK2-ALOX5 pathway
N01850  MYO5B-mediated vesicle transport
Disease
H00768  Autosomal recessive intellectual developmental disorder
H00773  Autosomal dominant intellectual developmental disorder
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    815 (CAMK2A)
   04310 Wnt signaling pathway
    815 (CAMK2A)
   04066 HIF-1 signaling pathway
    815 (CAMK2A)
   04020 Calcium signaling pathway
    815 (CAMK2A)
   04024 cAMP signaling pathway
    815 (CAMK2A)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    815 (CAMK2A)
  09143 Cell growth and death
   04114 Oocyte meiosis
    815 (CAMK2A)
   04217 Necroptosis
    815 (CAMK2A)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    815 (CAMK2A)
   04922 Glucagon signaling pathway
    815 (CAMK2A)
   04912 GnRH signaling pathway
    815 (CAMK2A)
   04921 Oxytocin signaling pathway
    815 (CAMK2A)
   04916 Melanogenesis
    815 (CAMK2A)
   04925 Aldosterone synthesis and secretion
    815 (CAMK2A)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    815 (CAMK2A)
  09154 Digestive system
   04971 Gastric acid secretion
    815 (CAMK2A)
  09156 Nervous system
   04725 Cholinergic synapse
    815 (CAMK2A)
   04728 Dopaminergic synapse
    815 (CAMK2A)
   04720 Long-term potentiation
    815 (CAMK2A)
   04722 Neurotrophin signaling pathway
    815 (CAMK2A)
  09157 Sensory system
   04740 Olfactory transduction
    815 (CAMK2A)
   04750 Inflammatory mediator regulation of TRP channels
    815 (CAMK2A)
  09158 Development and regeneration
   04360 Axon guidance
    815 (CAMK2A)
  09159 Environmental adaptation
   04713 Circadian entrainment
    815 (CAMK2A)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    815 (CAMK2A)
   05205 Proteoglycans in cancer
    815 (CAMK2A)
  09162 Cancer: specific types
   05214 Glioma
    815 (CAMK2A)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    815 (CAMK2A)
  09164 Neurodegenerative disease
   05012 Parkinson disease
    815 (CAMK2A)
   05022 Pathways of neurodegeneration - multiple diseases
    815 (CAMK2A)
  09165 Substance dependence
   05031 Amphetamine addiction
    815 (CAMK2A)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    815 (CAMK2A)
   05415 Diabetic cardiomyopathy
    815 (CAMK2A)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    815 (CAMK2A)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    815 (CAMK2A)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.17  Ca2+/calmodulin-dependent protein kinase
     815 (CAMK2A)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: CAMK group
  CAMK2 family
   815 (CAMK2A)
SSDB
Motif
Pfam: Pkinase CaMKII_AD PK_Tyr_Ser-Thr DUF4440 SnoaL_3 SnoaL_2 Kdo SnoaL_4
Other DBs
NCBI-GeneID: 815
NCBI-ProteinID: NP_741960
OMIM: 114078
HGNC: 1460
Ensembl: ENSG00000070808
UniProt: Q9UQM7 Q7LDD5 A8K161 Q8IWE0
Structure
LinkDB
Position
5:complement(150219491..150290130)
AA seq 478 aa
MATITCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLERE
ARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQIL
EAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYL
SPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTV
TPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLK
GAILTTMLATRNFSGGKSGGNKKSDGVKESSESTNTTIEDEDTKVRKQEIIKVTEQLIEA
ISNGDFESYTKMCDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIH
LMGDESACIAYIRITQYLDAGGIPRTAQSEETRVWHRRDGKWQIVHFHRSGAPSVLPH
NT seq 1437 nt   +upstreamnt  +downstreamnt
atggccaccatcacctgcacccgcttcacggaagagtaccagctcttcgaggaattgggc
aagggagccttctcggtggtgcgaaggtgtgtgaaggtgctggctggccaggagtatgct
gccaagatcatcaacacaaagaagctgtcagccagagaccatcagaagctggagcgtgaa
gcccgcatctgccgcctgctgaagcaccccaacatcgtccgactacatgacagcatctca
gaggagggacaccactacctgatcttcgacctggtcactggtggggaactgtttgaagat
atcgtggcccgggagtattacagtgaggcggatgccagtcactgtatccagcagatcctg
gaggctgtgctgcactgccaccagatgggggtggtgcaccgggacctgaagcctgagaat
ctgttgctggcctccaagctcaagggtgccgcagtgaagctggcagactttggcctggcc
atagaggtggagggggagcagcaggcatggtttgggtttgcagggactcctggatatctc
tccccagaagtgctgcggaaggacccgtacgggaagcctgtggacctgtgggcttgtggg
gtcatcctgtacatcctgctggttgggtaccccccgttctgggatgaggaccagcaccgc
ctgtaccagcagatcaaagccggcgcctatgatttcccatcgccggaatgggacactgtc
accccggaagccaaggatctgatcaataagatgctgaccattaacccatccaaacgcatc
acagctgccgaagcccttaagcacccctggatctcgcaccgctccaccgtggcatcctgc
atgcacagacaggagaccgtggactgcctgaagaagttcaatgccaggaggaaactgaag
ggagccattctcaccacgatgctggccaccaggaacttctccggagggaagagtggggga
aacaagaagagcgatggtgtgaaggaatcctcagagagcaccaacaccaccatcgaggat
gaagacaccaaagtgcggaaacaggaaattataaaagtgacagagcagctgattgaagcc
ataagcaatggagattttgagtcctacacgaagatgtgcgaccctggcatgacagccttc
gaacctgaggccctggggaacctggttgagggcctggacttccatcgattctattttgaa
aacctgtggtcccggaacagcaagcccgtgcacaccaccatcctgaatccccacatccac
ctgatgggcgacgagtcagcctgcatcgcctacatccgcatcacgcagtacctggacgct
ggcggcatcccacgcaccgcccagtcggaggagacccgtgtctggcaccgccgggatggc
aaatggcagatcgtccacttccacagatctggggcgccctccgtcctgccccactga

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