Homo sapiens (human): 5087
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Entry
5087 CDS
T01001
Symbol
PBX1, CAKUHED
Name
(RefSeq) PBX homeobox 1
KO
K09355
pre-B-cell leukemia transcription factor 1
Organism
hsa
Homo sapiens (human)
Pathway
hsa04148
Efferocytosis
hsa04927
Cortisol synthesis and secretion
hsa04934
Cushing syndrome
hsa05202
Transcriptional misregulation in cancer
Network
nt06240
Transcription (cancer)
nt06310
CRH-ACTH-cortisol signaling
nt06360
Cushing syndrome
nt06535
Efferocytosis
Element
N00117
E2A-PBX1 fusion to transcriptional activation
N00297
ACTH-cortisol signaling pathway
N00298
CYP11B1-CYP11B2 fusion to ACTH-cortisol signaling pathway
N00320
Mutation-activated PRKACA to ACTH-cortisol signaling pathway
N00321
Mutation-activated GNAS to ACTH-cortisol signaling pathway
N00322
Mutation-inactivated PRKAR1A to ACTH-cortisol signaling pathway
N00323
Mutation-inactivated PDE11A/PDE8B to ACTH-cortisol signaling pathway
N01778
Production of IL10 via the Sirtuin1 signaling cascade
Disease
H00001
B-cell acute lymphoblastic leukemia
H01867
Congenital anomalies of kidney and urinary tract
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09140 Cellular Processes
09141 Transport and catabolism
04148 Efferocytosis
5087 (PBX1)
09150 Organismal Systems
09152 Endocrine system
04927 Cortisol synthesis and secretion
5087 (PBX1)
09160 Human Diseases
09161 Cancer: overview
05202 Transcriptional misregulation in cancer
5087 (PBX1)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
5087 (PBX1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03000 Transcription factors [BR:
hsa03000
]
5087 (PBX1)
Transcription factors [BR:
hsa03000
]
Eukaryotic type
Helix-turn-helix
Homeo domain TALE
5087 (PBX1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PBC
Homeobox_KN
Homeodomain
HTH_3
DUF7260
UCH
LZ3wCH
EF-hand_2
Motif
Other DBs
NCBI-GeneID:
5087
NCBI-ProteinID:
NP_002576
OMIM:
176310
HGNC:
8632
Ensembl:
ENSG00000185630
UniProt:
P40424
A8K5V0
Structure
PDB
PDBj
LinkDB
All DBs
Position
1:164559184..164886047
Genome browser
AA seq
430 aa
AA seq
DB search
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDE
AQARKHALNCHRMKPALFNVLCEIKEKTVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGP
EKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVM
NLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNF
NKQATEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQE
EANIYAAKTAVTATNVSAHGSQANSPSTPNSAGSSSSFNMSNSGDLFMSVQSLNGDSYQG
AQVGANVQSQVDTLRHVISQTGGYSDGLAASQMYSPQGISANGGWQDATTPSSVTSPTEG
PGSVHSDTSN
NT seq
1293 nt
NT seq
+upstream
nt +downstream
nt
atggacgagcagcccaggctgatgcattcccatgctggggtcgggatggccggacacccc
ggcctgtcccagcacttgcaggatggggccggagggaccgagggggagggcgggaggaag
caggacattggagacattttacagcaaattatgaccatcacagaccagagtttggatgag
gcgcaggccagaaaacatgctttaaactgccacagaatgaagcctgccttgtttaatgtg
ttgtgtgaaatcaaagaaaaaacagttttgagtatccgaggagcccaggaggaggaaccc
acagacccccagctgatgcggctggacaacatgctgttagcggaaggcgtggcggggcct
gagaagggcggagggtcggcggcagcggcggcagcggcggcggcttctggaggggcaggt
tcagacaactcagtggagcattcagattacagagccaaactctcacagatcagacaaatc
taccatacggagctggagaaatacgagcaggcctgcaacgagttcaccacccacgtgatg
aatctcctgcgagagcaaagccggaccaggcccatctccccaaaggagattgagcggatg
gtcagcatcatccaccgcaagttcagctccatccagatgcagctcaagcagagcacgtgc
gaggcggtgatgatcctgcgttcccgatttctggatgcgcggcggaagagacggaatttc
aacaagcaagcgacagaaatcctgaatgaatatttctattcccatctcagcaacccttac
cccagtgaggaagccaaagaggagttagccaagaagtgtggcatcacagtctcccaggta
tcaaactggtttggaaataagcgaatccggtacaagaagaacataggtaaatttcaagag
gaagccaatatttatgctgccaaaacagctgtcactgctaccaatgtgtcagcccatgga
agccaagctaactcgccctcaactcccaactcggctggttcttccagttcttttaacatg
tcaaactctggagatttgttcatgagcgtgcagtcactcaatggggattcttaccaaggg
gcccaggttggagccaacgtgcaatcacaggtggatacccttcgccatgttatcagccag
acaggaggatacagtgatggactcgcagccagtcagatgtacagtccgcagggcatcagt
gctaatggaggttggcaggatgctactaccccttcatcagtgacctcccctacagaaggc
cctggcagtgttcactctgatacctccaactga
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