KEGG   Homo sapiens (human): 5087
Entry
5087              CDS       T01001                                 
Symbol
PBX1, CAKUHED
Name
(RefSeq) PBX homeobox 1
  KO
K09355  pre-B-cell leukemia transcription factor 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04148  Efferocytosis
hsa04927  Cortisol synthesis and secretion
hsa04934  Cushing syndrome
hsa05202  Transcriptional misregulation in cancer
Network
nt06240  Transcription (cancer)
nt06310  CRH-ACTH-cortisol signaling
nt06360  Cushing syndrome
nt06535  Efferocytosis
  Element
N00117  E2A-PBX1 fusion to transcriptional activation
N00297  ACTH-cortisol signaling pathway
N00298  CYP11B1-CYP11B2 fusion to ACTH-cortisol signaling pathway
N00320  Mutation-activated PRKACA to ACTH-cortisol signaling pathway
N00321  Mutation-activated GNAS to ACTH-cortisol signaling pathway
N00322  Mutation-inactivated PRKAR1A to ACTH-cortisol signaling pathway
N00323  Mutation-inactivated PDE11A/PDE8B to ACTH-cortisol signaling pathway
N01778  Production of IL10 via the Sirtuin1 signaling cascade
Disease
H00001  B-cell acute lymphoblastic leukemia
H01867  Congenital anomalies of kidney and urinary tract
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    5087 (PBX1)
 09150 Organismal Systems
  09152 Endocrine system
   04927 Cortisol synthesis and secretion
    5087 (PBX1)
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    5087 (PBX1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    5087 (PBX1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    5087 (PBX1)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Helix-turn-helix
   Homeo domain TALE
    5087 (PBX1)
SSDB
Motif
Pfam: PBC Homeobox_KN Homeodomain HTH_3 DUF7260 UCH LZ3wCH EF-hand_2
Other DBs
NCBI-GeneID: 5087
NCBI-ProteinID: NP_002576
OMIM: 176310
HGNC: 8632
Ensembl: ENSG00000185630
UniProt: P40424 A8K5V0
Structure
LinkDB
Position
1:164559184..164886047
AA seq 430 aa
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDE
AQARKHALNCHRMKPALFNVLCEIKEKTVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGP
EKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVM
NLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNF
NKQATEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQE
EANIYAAKTAVTATNVSAHGSQANSPSTPNSAGSSSSFNMSNSGDLFMSVQSLNGDSYQG
AQVGANVQSQVDTLRHVISQTGGYSDGLAASQMYSPQGISANGGWQDATTPSSVTSPTEG
PGSVHSDTSN
NT seq 1293 nt   +upstreamnt  +downstreamnt
atggacgagcagcccaggctgatgcattcccatgctggggtcgggatggccggacacccc
ggcctgtcccagcacttgcaggatggggccggagggaccgagggggagggcgggaggaag
caggacattggagacattttacagcaaattatgaccatcacagaccagagtttggatgag
gcgcaggccagaaaacatgctttaaactgccacagaatgaagcctgccttgtttaatgtg
ttgtgtgaaatcaaagaaaaaacagttttgagtatccgaggagcccaggaggaggaaccc
acagacccccagctgatgcggctggacaacatgctgttagcggaaggcgtggcggggcct
gagaagggcggagggtcggcggcagcggcggcagcggcggcggcttctggaggggcaggt
tcagacaactcagtggagcattcagattacagagccaaactctcacagatcagacaaatc
taccatacggagctggagaaatacgagcaggcctgcaacgagttcaccacccacgtgatg
aatctcctgcgagagcaaagccggaccaggcccatctccccaaaggagattgagcggatg
gtcagcatcatccaccgcaagttcagctccatccagatgcagctcaagcagagcacgtgc
gaggcggtgatgatcctgcgttcccgatttctggatgcgcggcggaagagacggaatttc
aacaagcaagcgacagaaatcctgaatgaatatttctattcccatctcagcaacccttac
cccagtgaggaagccaaagaggagttagccaagaagtgtggcatcacagtctcccaggta
tcaaactggtttggaaataagcgaatccggtacaagaagaacataggtaaatttcaagag
gaagccaatatttatgctgccaaaacagctgtcactgctaccaatgtgtcagcccatgga
agccaagctaactcgccctcaactcccaactcggctggttcttccagttcttttaacatg
tcaaactctggagatttgttcatgagcgtgcagtcactcaatggggattcttaccaaggg
gcccaggttggagccaacgtgcaatcacaggtggatacccttcgccatgttatcagccag
acaggaggatacagtgatggactcgcagccagtcagatgtacagtccgcagggcatcagt
gctaatggaggttggcaggatgctactaccccttcatcagtgacctcccctacagaaggc
cctggcagtgttcactctgatacctccaactga

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