KEGG   NETWORK: N01875
Entry
N01875                      Network                                
Name
NRG-ERBB2/ERBB3 pathway (P13K signaling)
Definition
NRG -- ERBB3 -- ERBB2 -> PI3K -> PIP3 -> AKT -> MTOR
  Expanded
(3084,9542) -- 2065 -- 2064 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -> 2475
Class
nt06543 NRG-ERBB signaling
Type
Reference
Pathway
hsa04012  ErbB signaling pathway
Gene
3084  NRG1; neuregulin 1
9542  NRG2; neuregulin 2
2065  ERBB3; erb-b2 receptor tyrosine kinase 3
2064  ERBB2; erb-b2 receptor tyrosine kinase 2
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
2475  MTOR; mechanistic target of rapamycin kinase
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:31351986
  Authors
Black LE, Longo JF, Carroll SL
  Title
Mechanisms of Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) Action in Human Neoplasia.
  Journal
Am J Pathol 189:1898-1912 (2019)
DOI:10.1016/j.ajpath.2019.06.008
Reference
PMID:35247506
  Authors
Zhang C, Mei W, Zeng C
  Title
Oncogenic Neuregulin 1 gene (NRG1) fusions in cancer: A potential new therapeutic opportunities.
  Journal
Biochim Biophys Acta Rev Cancer 1877:188707 (2022)
DOI:10.1016/j.bbcan.2022.188707
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