KEGG   NETWORK: N01880
Entry
N01880                      Network                                
Name
GRM1/5-interacting scaffold proteins
Definition
GRM1/5 == (DLG4,DLGAP1,SHANK,HOMER) == NMDAR
  Expanded
(2911,2915) == (1742,9229,(50944,22941,85358),(9456,9455,9454)) == (2902,2903,2904,2905,2906,116443,116444)
Class
nt06544 Neuroactive ligand signaling
Type
Reference
Pathway
hsa04724  Glutamatergic synapse
Gene
2911  GRM1; glutamate metabotropic receptor 1
2915  GRM5; glutamate metabotropic receptor 5
1742  DLG4; discs large MAGUK scaffold protein 4
9229  DLGAP1; DLG associated protein 1
50944  SHANK1; SH3 and multiple ankyrin repeat domains 1
22941  SHANK2; SH3 and multiple ankyrin repeat domains 2
85358  SHANK3; SH3 and multiple ankyrin repeat domains 3
9456  HOMER1; homer scaffold protein 1
9455  HOMER2; homer scaffold protein 2
9454  HOMER3; homer scaffold protein 3
2902  GRIN1; glutamate ionotropic receptor NMDA type subunit 1
2903  GRIN2A; glutamate ionotropic receptor NMDA type subunit 2A
2904  GRIN2B; glutamate ionotropic receptor NMDA type subunit 2B
2905  GRIN2C; glutamate ionotropic receptor NMDA type subunit 2C
2906  GRIN2D; glutamate ionotropic receptor NMDA type subunit 2D
116443  GRIN3A; glutamate ionotropic receptor NMDA type subunit 3A
116444  GRIN3B; glutamate ionotropic receptor NMDA type subunit 3B
Reference
PMID:22627790
  Authors
Radulovic J, Tronson NC
  Title
Preso1, mGluR5 and the machinery of pain.
  Journal
Nat Neurosci 15:805-7 (2012)
DOI:10.1038/nn.3118
Reference
PMID:26349010
  Authors
Matosin N, Fernandez-Enright F, Lum JS, Newell KA
  Title
Shifting towards a model of mGluR5 dysregulation in schizophrenia: Consequences for future schizophrenia treatment.
  Journal
Neuropharmacology 115:73-91 (2017)
DOI:10.1016/j.neuropharm.2015.08.003
Reference
PMID:25778620
  Authors
Matosin N, Fernandez-Enright F, Fung SJ, Lum JS, Engel M, Andrews JL, Huang XF, Weickert CS, Newell KA
  Title
Alterations of mGluR5 and its endogenous regulators Norbin, Tamalin and Preso1 in schizophrenia: towards a model of mGluR5 dysregulation.
  Journal
Acta Neuropathol 130:119-29 (2015)
DOI:10.1007/s00401-015-1411-6
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