KEGG   NETWORK: N01889
Entry
N01889                      Network                                
Name
Gbeta/gamma-KCNJ signaling
Definition
(GNAI,GNAO) // (GNB+GNG) -> KCNJ
  Expanded
((2770,2771,2773),2775) // ((2782,2783,2784,59345,10681)+(54331,2785,2786,2787,2788,94235,2790,2791,55970,51764,2792,2793)) -> (3760,3762,3763,3765)
Class
nt06544 Neuroactive ligand signaling
Type
Reference
Pathway
hsa04727  GABAergic synapse
Gene
2770  GNAI1; G protein subunit alpha i1
2771  GNAI2; G protein subunit alpha i2
2773  GNAI3; G protein subunit alpha i3
2775  GNAO1; G protein subunit alpha o1
2782  GNB1; G protein subunit beta 1
2783  GNB2; G protein subunit beta 2
2784  GNB3; G protein subunit beta 3
59345  GNB4; G protein subunit beta 4
10681  GNB5; G protein subunit beta 5
54331  GNG2; G protein subunit gamma 2
2785  GNG3; G protein subunit gamma 3
2786  GNG4; G protein subunit gamma 4
2787  GNG5; G protein subunit gamma 5
2788  GNG7; G protein subunit gamma 7
94235  GNG8; G protein subunit gamma 8
2790  GNG10; G protein subunit gamma 10
2791  GNG11; G protein subunit gamma 11
55970  GNG12; G protein subunit gamma 12
51764  GNG13; G protein subunit gamma 13
2792  GNGT1; G protein subunit gamma transducin 1
2793  GNGT2; G protein subunit gamma transducin 2
3760  KCNJ3; potassium inwardly rectifying channel subfamily J member 3
3762  KCNJ5; potassium inwardly rectifying channel subfamily J member 5
3763  KCNJ6; potassium inwardly rectifying channel subfamily J member 6
3765  KCNJ9; potassium inwardly rectifying channel subfamily J member 9
Reference
PMID:22110931
  Authors
Cooper MS, Przebinda AS
  Title
Synaptic conversion of chloride-dependent synapses in spinal nociceptive circuits: roles in neuropathic pain.
  Journal
Pain Res Treat 2011:738645 (2011)
DOI:10.1155/2011/738645
Reference
PMID:25116141
  Authors
Higley MJ
  Title
Localized GABAergic inhibition of dendritic Ca(2+) signalling.
  Journal
Nat Rev Neurosci 15:567-72 (2014)
DOI:10.1038/nrn3803
Reference
PMID:28825683
  Authors
Govindpani K, Calvo-Flores Guzman B, Vinnakota C, Waldvogel HJ, Faull RL, Kwakowsky A
  Title
Towards a Better Understanding of GABAergic Remodeling in Alzheimer's Disease.
  Journal
Int J Mol Sci 18:ijms18081813 (2017)
DOI:10.3390/ijms18081813
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