Homo sapiens (human): 3762
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Entry
3762 CDS
T01001
Symbol
KCNJ5, CIR, GIRK4, KATP1, KIR3.4, LQT13
Name
(RefSeq) potassium inwardly rectifying channel subfamily J member 5
KO
K04999
potassium inwardly-rectifying channel subfamily J member 5
Organism
hsa
Homo sapiens (human)
Pathway
hsa04713
Circadian entrainment
hsa04723
Retrograde endocannabinoid signaling
hsa04726
Serotonergic synapse
hsa04728
Dopaminergic synapse
hsa04915
Estrogen signaling pathway
hsa04921
Oxytocin signaling pathway
hsa04925
Aldosterone synthesis and secretion
hsa04929
GnRH secretion
hsa05032
Morphine addiction
Network
nt06316
Renin-angiotensin-aldosterone signaling
nt06544
Neuroactive ligand signaling
Element
N00303
Mutation-activated KCNJ5 to angiotensin-aldosterone signaling pathway
N01889
Gbeta/gamma-KCNJ signaling
Disease
H00720
Long QT syndrome
H01603
Primary aldosteronism
Drug target
Amiodarone (
DG00204
):
D00636
<JP/US>
D02910
Bepridil (
DG00333
):
D00631
<JP>
D07520
Dronedarone (
DG00207
):
D02537
D03914
<US>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09150 Organismal Systems
09152 Endocrine system
04929 GnRH secretion
3762 (KCNJ5)
04915 Estrogen signaling pathway
3762 (KCNJ5)
04921 Oxytocin signaling pathway
3762 (KCNJ5)
04925 Aldosterone synthesis and secretion
3762 (KCNJ5)
09156 Nervous system
04728 Dopaminergic synapse
3762 (KCNJ5)
04726 Serotonergic synapse
3762 (KCNJ5)
04723 Retrograde endocannabinoid signaling
3762 (KCNJ5)
09159 Environmental adaptation
04713 Circadian entrainment
3762 (KCNJ5)
09160 Human Diseases
09165 Substance dependence
05032 Morphine addiction
3762 (KCNJ5)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04040 Ion channels [BR:
hsa04040
]
3762 (KCNJ5)
Ion channels [BR:
hsa04040
]
Voltage-gated cation channels
Potassium channel, inwardly-rectifying (Kir)
3762 (KCNJ5)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
IRK_C
IRK
Ion_trans
Ion_trans_2
Motif
Other DBs
NCBI-GeneID:
3762
NCBI-ProteinID:
NP_000881
OMIM:
600734
HGNC:
6266
Ensembl:
ENSG00000120457
UniProt:
P48544
A0A5J6E2W8
LinkDB
All DBs
Position
11:128891356..128921163
Genome browser
AA seq
419 aa
AA seq
DB search
MAGDSRNAMNQDMEIGVTPWDPKKIPKQARDYVPIATDRTRLLAEGKKPRQRYMEKSGKC
NVHHGNVQETYRYLSDLFTTLVDLKWRFNLLVFTMVYTVTWLFFGFIWWLIAYIRGDLDH
VGDQEWIPCVENLSGFVSAFLFSIETETTIGYGFRVITEKCPEGIILLLVQAILGSIVNA
FMVGCMFVKISQPKKRAETLMFSNNAVISMRDEKLCLMFRVGDLRNSHIVEASIRAKLIK
SRQTKEGEFIPLNQTDINVGFDTGDDRLFLVSPLIISHEINQKSPFWEMSQAQLHQEEFE
VVVILEGMVEATGMTCQARSSYMDTEVLWGHRFTPVLTLEKGFYEVDYNTFHDTYETNTP
SCCAKELAEMKREGRLLQYLPSPPLLGGCAEAGLDAEAEQNEEDEPKGLGGSREARGSV
NT seq
1260 nt
NT seq
+upstream
nt +downstream
nt
atggctggcgattctaggaatgccatgaaccaggacatggagattggagtcactccctgg
gaccccaagaagattccaaaacaggcccgcgattatgtccccattgccacagaccgtacg
cgcctgctggccgagggcaagaagccacgccagcgctacatggagaagagtggcaagtgc
aacgtgcaccacggcaacgtccaggagacctaccggtacctgagtgacctcttcaccacc
ctggtggacctcaagtggcgcttcaacttgctcgtcttcaccatggtttacactgtcacc
tggctgttcttcggcttcatttggtggctcattgcttatatccggggtgacctggaccat
gttggcgaccaagagtggattccttgtgttgaaaacctcagtggcttcgtgtccgctttc
ctgttctccattgagaccgaaacaaccattgggtatggcttccgagtcatcacagagaag
tgtccagaggggattatactcctcttggtccaggccatcctgggctccatcgtcaatgcc
ttcatggtggggtgcatgtttgtcaagatcagccagcccaagaagagagcggagaccctc
atgttttccaacaacgcagtcatctccatgcgggacgagaagctgtgcctcatgttccgg
gtgggcgacctccgcaactcccacatcgtggaggcctccatccgggccaagctcatcaag
tcccggcagaccaaagagggggagttcatccccctgaaccagacagacatcaacgtgggc
tttgacacgggcgacgaccgcctcttccttgtgtctcctctgatcatctcccatgagatc
aaccagaagagccctttctgggagatgtctcaggctcagctgcatcaggaagagtttgaa
gttgtggtcattctagaagggatggtggaagccacaggcatgacctgccaagcccggagc
tcctacatggatacagaggtgctctggggccaccgattcacaccagtcctcaccttggaa
aagggcttctatgaggtggactacaacaccttccatgatacctatgagaccaacacaccc
agctgctgtgccaaggagctggcagaaatgaagagggaaggccggctcctccagtacctc
cccagccccccactgctggggggctgtgctgaggcagggctggatgcagaggctgagcag
aatgaagaagatgagcccaaggggctgggtgggtccagggaggccaggggctcggtgtga
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