KEGG   NETWORK: N01980
Entry
N01980                      Network                                
Name
Integrin alpha5beta1 signaling
Definition
(FN1,FBN1,DPP,OPN,THBS,LAP) -> ITGA5+ITGB1 -> (Adaptor,FAK,Src)
  Expanded
(2335,2200,1834,6696,(7057,7058,7059,7060,1311),(7057,7058,7059,7060,1311),7040) -> 3678+3688 -> (((2316,2317),(7094,83660),(81,87),5829,7414,(55612,10979,83706),(55742,29780,64098),(3987,55679)),5747,6714)
Class
nt06548 Integrin signaling
Type
Reference
Pathway
hsa04518 Integrin signaling   
Gene
2335  FN1; fibronectin 1
2200  FBN1; fibrillin 1
1834  DSPP; dentin sialophosphoprotein
6696  SPP1; secreted phosphoprotein 1
7057  THBS1; thrombospondin 1
7058  THBS2; thrombospondin 2
7059  THBS3; thrombospondin 3
7060  THBS4; thrombospondin 4
1311  COMP; cartilage oligomeric matrix protein
7040  TGFB1; transforming growth factor beta 1
3678  ITGA5; integrin subunit alpha 5
3688  ITGB1; integrin subunit beta 1
2316  FLNA; filamin A
2317  FLNB; filamin B
7094  TLN1; talin 1
83660  TLN2; talin 2
81  ACTN4; actinin alpha 4
87  ACTN1; actinin alpha 1
5829  PXN; paxillin
7414  VCL; vinculin
55612  FERMT1; FERM domain containing kindlin 1
10979  FERMT2; FERM domain containing kindlin 2
83706  FERMT3; FERM domain containing kindlin 3
55742  PARVA; parvin alpha
29780  PARVB; parvin beta
64098  PARVG; parvin gamma
3987  LIMS1; LIM zinc finger domain containing 1
55679  LIMS2; LIM zinc finger domain containing 2
5747  PTK2; protein tyrosine kinase 2
6714  SRC; SRC proto-oncogene, non-receptor tyrosine kinase
Reference
PMID:22633092
  Authors
Goodman SL, Picard M
  Title
Integrins as therapeutic targets.
  Journal
Trends Pharmacol Sci 33:405-12 (2012)
DOI:10.1016/j.tips.2012.04.002
Reference
PMID:17543136
  Authors
Takada Y, Ye X, Simon S
  Title
The integrins.
  Journal
Genome Biol 8:215 (2007)
DOI:10.1186/gb-2007-8-5-215
Reference
PMID:36588107
  Authors
Pang X, He X, Qiu Z, Zhang H, Xie R, Liu Z, Gu Y, Zhao N, Xiang Q, Cui Y
  Title
Targeting integrin pathways: mechanisms and advances in therapy.
  Journal
Signal Transduct Target Ther 8:1 (2023)
DOI:10.1038/s41392-022-01259-6
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