Homo sapiens (human): 3678
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Entry
3678 CDS
T01001
Symbol
ITGA5, CD49e, FNRA, VLA-5, VLA5A
Name
(RefSeq) integrin subunit alpha 5
KO
K06484
integrin alpha 5
Organism
hsa
Homo sapiens (human)
Pathway
hsa03266
Virion - Herpesvirus
hsa04145
Phagosome
hsa04151
PI3K-Akt signaling pathway
hsa04510
Focal adhesion
hsa04512
ECM-receptor interaction
hsa04640
Hematopoietic cell lineage
hsa04810
Regulation of actin cytoskeleton
hsa04820
Cytoskeleton in muscle cells
hsa05100
Bacterial invasion of epithelial cells
hsa05131
Shigellosis
hsa05133
Pertussis
hsa05135
Yersinia infection
hsa05165
Human papillomavirus infection
hsa05168
Herpes simplex virus 1 infection
hsa05205
Proteoglycans in cancer
hsa05206
MicroRNAs in cancer
hsa05410
Hypertrophic cardiomyopathy
hsa05412
Arrhythmogenic right ventricular cardiomyopathy
hsa05414
Dilated cardiomyopathy
Network
nt06167
Human cytomegalovirus (HCMV)
nt06180
Pathogenic Escherichia coli
nt06181
Salmonella
nt06182
Shigella
nt06183
Yersinia
Element
N00393
ITGA/B-RhoGAP-RhoA signaling pathway
N00951
ITGA/B-RHOG-RAC signaling pathway
N01068
ITGA/B-FAK-RAC signaling pathway
N01070
ITGA/B-FAK-CDC42 signaling pathway
N01072
ITGA/B-RhoGEF-RhoA signaling pathway
N01080
ITGA/B-TALIN/VINCULIN signaling pathway
N01081
Shigella IpaB/C/D to ITGA/B-TALIN/VINCULIN signaling pathway
Drug target
Bexotegrast:
D12722
Volociximab:
D06319
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09120 Genetic Information Processing
09125 Information processing in viruses
03266 Virion - Herpesvirus
3678 (ITGA5)
09130 Environmental Information Processing
09132 Signal transduction
04151 PI3K-Akt signaling pathway
3678 (ITGA5)
09133 Signaling molecules and interaction
04512 ECM-receptor interaction
3678 (ITGA5)
09140 Cellular Processes
09141 Transport and catabolism
04145 Phagosome
3678 (ITGA5)
09142 Cell motility
04820 Cytoskeleton in muscle cells
3678 (ITGA5)
09150 Organismal Systems
09151 Immune system
04640 Hematopoietic cell lineage
3678 (ITGA5)
09160 Human Diseases
09161 Cancer: overview
05206 MicroRNAs in cancer
3678 (ITGA5)
05205 Proteoglycans in cancer
3678 (ITGA5)
09172 Infectious disease: viral
05165 Human papillomavirus infection
3678 (ITGA5)
09171 Infectious disease: bacterial
05131 Shigellosis
3678 (ITGA5)
05135 Yersinia infection
3678 (ITGA5)
05133 Pertussis
3678 (ITGA5)
05100 Bacterial invasion of epithelial cells
3678 (ITGA5)
09166 Cardiovascular disease
05410 Hypertrophic cardiomyopathy
3678 (ITGA5)
05412 Arrhythmogenic right ventricular cardiomyopathy
3678 (ITGA5)
05414 Dilated cardiomyopathy
3678 (ITGA5)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
hsa04147
]
3678 (ITGA5)
04515 Cell adhesion molecules [BR:
hsa04515
]
3678 (ITGA5)
04090 CD molecules [BR:
hsa04090
]
3678 (ITGA5)
Exosome [BR:
hsa04147
]
Exosomal proteins
Exosomal proteins of haemopoietic cells (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
3678 (ITGA5)
Cell adhesion molecules [BR:
hsa04515
]
Integrins
Integrin alpha subunits
3678 (ITGA5)
CD molecules [BR:
hsa04090
]
Proteins
3678 (ITGA5)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Integrin_A_Ig_3
Integrin_A_Ig_1
Integrin_A_Ig_2
FG-GAP
FG-GAP_3
Integrin_alpha
ITGAX-like_Ig_3
DUF7252
Motif
Other DBs
NCBI-GeneID:
3678
NCBI-ProteinID:
NP_002196
OMIM:
135620
HGNC:
6141
Ensembl:
ENSG00000161638
UniProt:
P08648
B2R627
Structure
PDB
PDBj
LinkDB
All DBs
Position
12:complement(54395261..54419266)
Genome browser
AA seq
1049 aa
AA seq
DB search
MGSRTPESPLHAVQLRWGPRRRPPLLPLLLLLLPPPPRVGGFNLDAEAPAVLSGPPGSFF
GFSVEFYRPGTDGVSVLVGAPKANTSQPGVLQGGAVYLCPWGASPTQCTPIEFDSKGSRL
LESSLSSSEGEEPVEYKSLQWFGATVRAHGSSILACAPLYSWRTEKEPLSDPVGTCYLST
DNFTRILEYAPCRSDFSWAAGQGYCQGGFSAEFTKTGRVVLGGPGSYFWQGQILSATQEQ
IAESYYPEYLINLVQGQLQTRQASSIYDDSYLGYSVAVGEFSGDDTEDFVAGVPKGNLTY
GYVTILNGSDIRSLYNFSGEQMASYFGYAVAATDVNGDGLDDLLVGAPLLMDRTPDGRPQ
EVGRVYVYLQHPAGIEPTPTLTLTGHDEFGRFGSSLTPLGDLDQDGYNDVAIGAPFGGET
QQGVVFVFPGGPGGLGSKPSQVLQPLWAASHTPDFFGSALRGGRDLDGNGYPDLIVGSFG
VDKAVVYRGRPIVSASASLTIFPAMFNPEERSCSLEGNPVACINLSFCLNASGKHVADSI
GFTVELQLDWQKQKGGVRRALFLASRQATLTQTLLIQNGAREDCREMKIYLRNESEFRDK
LSPIHIALNFSLDPQAPVDSHGLRPALHYQSKSRIEDKAQILLDCGEDNICVPDLQLEVF
GEQNHVYLGDKNALNLTFHAQNVGEGGAYEAELRVTAPPEAEYSGLVRHPGNFSSLSCDY
FAVNQSRLLVCDLGNPMKAGASLWGGLRFTVPHLRDTKKTIQFDFQILSKNLNNSQSDVV
SFRLSVEAQAQVTLNGVSKPEAVLFPVSDWHPRDQPQKEEDLGPAVHHVYELINQGPSSI
SQGVLELSCPQALEGQQLLYVTRVTGLNCTTNHPINPKGLELDPEGSLHHQQKREAPSRS
SASSGPQILKCPEAECFRLRCELGPLHQQESQSLQLHFRVWAKTFLQREHQPFSLQCEAV
YKALKMPYRILPRQLPQKERQVATAVQWTKAEGSYGVPLWIIILAILFGLLLLGLLIYIL
YKLGFFKRSLPYGTAMEKAQLKPPATSDA
NT seq
3150 nt
NT seq
+upstream
nt +downstream
nt
atggggagccggacgccagagtcccctctccacgccgtgcagctgcgctggggcccccgg
cgccgacccccgctgctgccgctgctgttgctgctgctgccgccgccacccagggtcggg
ggcttcaacttagacgcggaggccccagcagtactctcggggcccccgggctccttcttc
ggattctcagtggagttttaccggccgggaacagacggggtcagtgtgctggtgggagca
cccaaggctaataccagccagccaggagtgctgcagggtggtgctgtctacctctgtcct
tggggtgccagccccacacagtgcacccccattgaatttgacagcaaaggctctcggctc
ctggagtcctcactgtccagctcagagggagaggagcctgtggagtacaagtccttgcag
tggttcggggcaacagttcgagcccatggctcctccatcttggcatgcgctccactgtac
agctggcgcacagagaaggagccactgagcgaccccgtgggcacctgctacctctccaca
gataacttcacccgaattctggagtatgcaccctgccgctcagatttcagctgggcagca
ggacagggttactgccaaggaggcttcagtgccgagttcaccaagactggccgtgtggtt
ttaggtggaccaggaagctatttctggcaaggccagatcctgtctgccactcaggagcag
attgcagaatcttattaccccgagtacctgatcaacctggttcaggggcagctgcagact
cgccaggccagttccatctatgatgacagctacctaggatactctgtggctgttggtgaa
ttcagtggtgatgacacagaagactttgttgctggtgtgcccaaagggaacctcacttac
ggctatgtcaccatccttaatggctcagacattcgatccctctacaacttctcaggggaa
cagatggcctcctactttggctatgcagtggccgccacagacgtcaatggggacgggctg
gatgacttgctggtgggggcacccctgctcatggatcggacccctgacgggcggcctcag
gaggtgggcagggtctacgtctacctgcagcacccagccggcatagagcccacgcccacc
cttaccctcactggccatgatgagtttggccgatttggcagctccttgacccccctgggg
gacctggaccaggatggctacaatgatgtggccatcggggctccctttggtggggagacc
cagcagggagtagtgtttgtatttcctgggggcccaggagggctgggctctaagccttcc
caggttctgcagcccctgtgggcagccagccacaccccagacttctttggctctgccctt
cgaggaggccgagacctggatggcaatggatatcctgatctgattgtggggtcctttggt
gtggacaaggctgtggtatacaggggccgccccatcgtgtccgctagtgcctccctcacc
atcttccccgccatgttcaacccagaggagcggagctgcagcttagaggggaaccctgtg
gcctgcatcaaccttagcttctgcctcaatgcttctggaaaacacgttgctgactccatt
ggtttcacagtggaacttcagctggactggcagaagcagaagggaggggtacggcgggca
ctgttcctggcctccaggcaggcaaccctgacccagaccctgctcatccagaatggggct
cgagaggattgcagagagatgaagatctacctcaggaacgagtcagaatttcgagacaaa
ctctcgccgattcacatcgctctcaacttctccttggacccccaagccccagtggacagc
cacggcctcaggccagccctacattatcagagcaagagccggatagaggacaaggctcag
atcttgctggactgtggagaagacaacatctgtgtgcctgacctgcagctggaagtgttt
ggggagcagaaccatgtgtacctgggtgacaagaatgccctgaacctcactttccatgcc
cagaatgtgggtgagggtggcgcctatgaggctgagcttcgggtcaccgcccctccagag
gctgagtactcaggactcgtcagacacccagggaacttctccagcctgagctgtgactac
tttgccgtgaaccagagccgcctgctggtgtgtgacctgggcaaccccatgaaggcagga
gccagtctgtggggtggccttcggtttacagtccctcatctccgggacactaagaaaacc
atccagtttgacttccagatcctcagcaagaatctcaacaactcgcaaagcgacgtggtt
tcctttcggctctccgtggaggctcaggcccaggtcaccctgaacggtgtctccaagcct
gaggcagtgctattcccagtaagcgactggcatccccgagaccagcctcagaaggaggag
gacctgggacctgctgtccaccatgtctatgagctcatcaaccaaggccccagctccatt
agccagggtgtgctggaactcagctgtccccaggctctggaaggtcagcagctcctatat
gtgaccagagttacgggactcaactgcaccaccaatcaccccattaacccaaagggcctg
gagttggatcccgagggttccctgcaccaccagcaaaaacgggaagctccaagccgcagc
tctgcttcctcgggacctcagatcctgaaatgcccggaggctgagtgtttcaggctgcgc
tgtgagctcgggcccctgcaccaacaagagagccaaagtctgcagttgcatttccgagtc
tgggccaagactttcttgcagcgggagcaccagccatttagcctgcagtgtgaggctgtg
tacaaagccctgaagatgccctaccgaatcctgcctcggcagctgccccaaaaagagcgt
caggtggccacagctgtgcaatggaccaaggcagaaggcagctatggcgtcccactgtgg
atcatcatcctagccatcctgtttggcctcctgctcctaggtctactcatctacatcctc
tacaagcttggattcttcaaacgctccctcccatatggcaccgccatggaaaaagctcag
ctcaagcctccagccacctctgatgcctga
DBGET
integrated database retrieval system
