| Entry |
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| Name |
EIF2B inhibition by phosphorylation of eIF2alpha
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| Definition |
(EIF2AK1,EIF2AK2,EIF2AK3,EIF2AK4) -- (EIF2S1+Pi) -| EIF2B |
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| Expanded |
(27102,5610,9451,440275) -- (1965+C00009) -| (1967+8892+8891+8890+8893) |
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| Class |
nt06552 Integrated stress response (ISR) signaling pathway
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| Type |
Reference
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| Pathway |
| hsa04156 Integrated stress response (ISR) signaling pathway | |
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| Gene |
| 27102 | EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 isoform a |
| 5610 | EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform a |
| 9451 | EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform 1 precursor |
| 440275 | EIF2AK4; eIF-2-alpha kinase GCN2 |
| 1965 | EIF2S1; eukaryotic translation initiation factor 2 subunit 1 |
| 1967 | EIF2B1; translation initiation factor eIF2B subunit alpha |
| 8892 | EIF2B2; translation initiation factor eIF2B subunit beta |
| 8891 | EIF2B3; translation initiation factor eIF2B subunit gamma isoform 1 |
| 8890 | EIF2B4; translation initiation factor eIF2B subunit delta isoform 2 |
| 8893 | EIF2B5; translation initiation factor eIF2B subunit epsilon |
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| Metabolite |
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| Reference |
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| Authors |
Marintchev A, Ito T |
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| Title |
eIF2B and the Integrated Stress Response: A Structural and Mechanistic View. |
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| Journal |
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| Reference |
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| Authors |
Gordiyenko Y, Llacer JL, Ramakrishnan V |
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| Title |
Structural basis for the inhibition of translation through eIF2alpha phosphorylation. |
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| Journal |
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| LinkDB |
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