KEGG   Homo sapiens (human): 1967
Entry
1967              CDS       T01001                                 
Symbol
EIF2B1, EIF2B, EIF2BA, EIF2Balpha, VWM1
Name
(RefSeq) translation initiation factor eIF2B subunit alpha
  KO
K03239  translation initiation factor eIF-2B subunit alpha
Organism
hsa  Homo sapiens (human)
Pathway
hsa04156  Integrated stress response (ISR) signaling pathway
hsa05168  Herpes simplex virus 1 infection
Network
nt06168  Herpes simplex virus 1 (HSV-1)
nt06169  Measles virus (MV)
nt06170  Influenza A virus (IAV)
nt06552  Integrated stress response (ISR) signaling pathway
  Element
N00571  PKR-eIF2alpha signaling pathway
N02046  Formation of the ternary complex (TC) for ribosomal translation initiation
N02047  EIF2B inhibition by phosphorylation of eIF2alpha
N02048  Inactive complex formation by phosphorylation of eIF2alpha
Disease
H00869  Leukoencephalopathy with vanishing white matter
Drug target
Fosigotifator (DG03349): D13118 D13119
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04156 Integrated stress response (ISR) signaling pathway
    1967 (EIF2B1)
 09160 Human Diseases
  09172 Infectious disease: viral
   05168 Herpes simplex virus 1 infection
    1967 (EIF2B1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03012 Translation factors [BR:hsa03012]
    1967 (EIF2B1)
Translation factors [BR:hsa03012]
 Eukaryotic type
  Initiation factors
   eIF-2B
    1967 (EIF2B1)
SSDB
Motif
Pfam: IF-2B
Other DBs
NCBI-GeneID: 1967
NCBI-ProteinID: NP_001405
OMIM: 606686
HGNC: 3257
Ensembl: ENSP00000416250.2
UniProt: Q14232
Structure
LinkDB
Position
12:complement(123620406..123633686)
AA seq 305 aa
MDDKELIEYFKSQMKEDPDMASAVAAIRTLLEFLKRDKGETIQGLRANLTSAIETLCGVD
SSVAVSSGGELFLRFISLASLEYSDYSKCKKIMIERGELFLRRISLSRNKIADLCHTFIK
DGATILTHAYSRVVLRVLEAAVAAKKRFSVYVTESQPDLSGKKMAKALCHLNVPVTVVLD
AAVGYIMEKADLVIVGAEGVVENGGIINKIGTNQMAVCAKAQNKPFYVVAESFKFVRLFP
LNQQDVPDKFKYKADTLKVAQTGQDLKEEHPWVDYTAPSLITLLFTDLGVLTPSAVSDEL
IKLYL
NT seq 918 nt   +upstreamnt  +downstreamnt
atggacgacaaggagttaattgaatactttaagtctcagatgaaagaagatcctgacatg
gcctcagcagtggctgccatccggacgttgctggagttcttgaagagagataaaggggag
acaatccagggtctgagggcgaatctcaccagtgccatagaaaccctgtgtggtgtggac
tcctctgtggcagtgtcctctggcggggagctcttcctccgcttcatcagtcttgcctcc
ctggaatactccgattactccaaatgtaaaaagatcatgattgagcggggagaacttttt
ctcaggagaatatcactgtcaagaaacaaaattgcagatctgtgccatactttcatcaaa
gatggagcgacaatattgactcacgcctactccagagtggtcctgagagtcctggaagca
gccgtggcggccaagaagcgatttagtgtatacgtcacagagtcacagcctgatttgtca
ggtaagaaaatggccaaagccctctgccacctcaacgtccctgtcactgtggtgctagat
gctgctgtcggctacatcatggagaaagcagatcttgtcatagttggtgctgaaggagtt
gttgaaaacggaggaattattaacaagattggaaccaaccagatggctgtgtgtgccaaa
gcacagaacaaacctttctatgtggttgcagaaagtttcaagtttgtccggctctttcca
ctaaaccagcaagacgtcccagataagtttaagtataaggcagacactctcaaggtcgcg
cagactggacaagacctcaaagaggagcatccgtgggtcgactacactgccccttcctta
atcactctgctgtttacagacctgggcgtgctgacaccctcagcagtcagcgatgagctc
atcaagctctatctgtaa

DBGET integrated database retrieval system