KEGG   REACTION: R00074
Entry
R00074                      Reaction                               
Name
2-aminophenol:oxygen oxidoreductase (dimerizing)
Definition
4 2-Aminophenol + 3 Oxygen <=> 2 2-Aminophenoxazin-3-one + 6 H2O
Equation
4 C01987 + 3 C00007 <=> 2 C02161 + 6 C00001
Comment
multi-step reaction (see R08762+R08763)
Reaction class
RC00767  C01987_C02161
RC02319  C01987_C02161
Enzyme
1.10.3.4
Pathway
rn00380  Tryptophan metabolism
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.10  Acting on diphenols and related substances as donors
   1.10.3  With oxygen as acceptor
    1.10.3.4
     R00074  4 2-Aminophenol + 3 Oxygen <=> 2 2-Aminophenoxazin-3-one + 6 H2O
Orthology
K20204  grixazone synthase / o-aminophenol oxidase [EC:1.10.3.15 1.10.3.4]
K20219  o-aminophenol oxidase [EC:1.10.3.4]
Reference
1  [PMID:14298835]
  Authors
NAIR PM, VINING LC.
  Title
ESOPHENOXAZINE SYNTHASE APOENZYME FROM PYCNOPORUS COCCINEUS.
  Journal
Biochim Biophys Acta 96:318-27 (1965)
DOI:10.1016/0005-2787(65)90594-0
Reference
2  [PMID:4166439]
  Authors
Subba Rao PV, Vaidyanathan CS.
  Title
Studies on the metabolism of o-aminophenol. Purification and properties of isophenoxazine synthase from Bauhenia monandra.
  Journal
Arch Biochem Biophys 118:388-94 (1967)
DOI:10.1016/0003-9861(67)90365-7
Reference
3  [PMID:16282322]
  Authors
Suzuki H, Furusho Y, Higashi T, Ohnishi Y, Horinouchi S
  Title
A novel o-aminophenol oxidase responsible for formation of the phenoxazinone chromophore of grixazone.
  Journal
J Biol Chem 281:824-33 (2006)
DOI:10.1074/jbc.M505806200
Other DBs
RHEA: 40966
LinkDB

KEGG   REACTION: R08762
Entry
R08762                      Reaction                               
Name
2-aminophenol:oxygen oxidoreductase
Definition
2 2-Aminophenol + Oxygen <=> 2 6-Iminocyclohexa-2,4-dienone + 2 H2O
Equation
2 C01987 + C00007 <=> 2 C17500 + 2 C00001
Comment
the former part of multi-step reaction (see R00074, R08762+R08763)
subsequently R08763
Reaction class
RC02320  C01987_C17500
Enzyme
1.10.3.4
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.10  Acting on diphenols and related substances as donors
   1.10.3  With oxygen as acceptor
    1.10.3.4
     R08762  2 2-Aminophenol + Oxygen <=> 2 6-Iminocyclohexa-2,4-dienone + 2 H2O
Other DBs
RHEA: 14684
LinkDB

KEGG   REACTION: R08763
Entry
R08763                      Reaction                               
Name
6-iminocyclohexa-2,4-dienone oxidoreductase (dimerizing)
Definition
2 6-Iminocyclohexa-2,4-dienone + Acceptor <=> 2-Aminophenoxazin-3-one + Reduced acceptor
Equation
2 C17500 + C00028 <=> C02161 + C00030
Comment
spontaneous
incomplete reaction (unidentified acceptor, probably [CPD:C00007] or [CPD:C17500])
the latter part of multi-step reaction (see R00074, R08762+R08763)
following after R08762
Reaction class
RC02321  C02161_C17500
RC03123  C02161_C17500
Enzyme
1.10.3.4
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.10  Acting on diphenols and related substances as donors
   1.10.3  With oxygen as acceptor
    1.10.3.4
     R08763  2 6-Iminocyclohexa-2,4-dienone + Acceptor <=> 2-Aminophenoxazin-3-one + Reduced acceptor
LinkDB

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