KEGG   REACTION: R01218
Entry
R01218                      Reaction                               
Name
5,10-methylenetetrahydrofolate:NAD+ oxidoreductase
Definition
5,10-Methylenetetrahydrofolate + NAD+ <=> 5,10-Methenyltetrahydrofolate + NADH
Equation
C00143 + C00003 <=> C00445 + C00004
Reaction class
RC00001  C00003_C00004
RC00202  C00143_C00445
Enzyme
1.5.1.15
Pathway
rn00670  One carbon pool by folate
rn01100  Metabolic pathways
rn01240  Biosynthesis of cofactors
Module
M00141  C1-unit interconversion, eukaryotes
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.15
     R01218  5,10-Methylenetetrahydrofolate + NAD+ <=> 5,10-Methenyltetrahydrofolate + NADH
Orthology
K00295  methylenetetrahydrofolate dehydrogenase (NAD+) [EC:1.5.1.15]
K13403  methylenetetrahydrofolate dehydrogenase(NAD+) / 5,10-methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.15 3.5.4.9]
Other DBs
RHEA: 22895
LinkDB

KEGG   RCLASS: RC00202
Entry
RC00202                     RClass                                 
Definition
C1x-C2x:*-*:N1y+N1y-N1y+N2y
N1y-N2y:*-*:C1x+C1y+C8y-C2x+C1y+C8y
Reactant pair
C00143_C00445    C04330_C04377
Related class
Reaction
R01218 R01220 R04455 R04456 R08059
Enzyme
1.5.1.5         1.5.1.15        1.5.1.-         1.5.98.1        
1.12.98.2
Pathway
rn00670  One carbon pool by folate
rn00680  Methane metabolism
rn00720  Other carbon fixation pathways
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
rn01240  Biosynthesis of cofactors
Orthology
K00288  methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase [EC:1.5.1.5 3.5.4.9 6.3.4.3]
K00295  methylenetetrahydrofolate dehydrogenase (NAD+) [EC:1.5.1.15]
K00300  methylenetetrahydrofolate/methylenetetrahydromethanopterin dehydrogenase (NADP+) [EC:1.5.1.5 1.5.1.-]
K00319  methylenetetrahydromethanopterin dehydrogenase [EC:1.5.98.1]
K01491  methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.5 3.5.4.9]
K10714  methylene-tetrahydromethanopterin dehydrogenase [EC:1.5.1.-]
K13403  methylenetetrahydrofolate dehydrogenase(NAD+) / 5,10-methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.15 3.5.4.9]
K13942  5,10-methenyltetrahydromethanopterin hydrogenase [EC:1.12.98.2]

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