KEGG   REACTION: R01246
Entry
R01246                      Reaction                               
Name
L-proline:NAD+ 2-oxidoreductase
Definition
L-Proline + NAD+ <=> 1-Pyrroline-2-carboxylate + NADH + H+
Equation
C00148 + C00003 <=> C03564 + C00004 + C00080
Comment
NADP+ (see R01249)
Reaction class
RC00001  C00003_C00004
RC00135  C00148_C03564
Enzyme
1.5.1.1         1.5.1.49
Pathway
rn00330  Arginine and proline metabolism
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.1
     R01246  L-Proline + NAD+ <=> 1-Pyrroline-2-carboxylate + NADH + H+
    1.5.1.49
     R01246  L-Proline + NAD+ <=> 1-Pyrroline-2-carboxylate + NADH + H+
Orthology
K19742  1-pyrroline-2-carboxylate reductase [NAD(P)H] [EC:1.5.1.49]
K19743  1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H] [EC:1.5.1.1]
Other DBs
RHEA: 20324
LinkDB

KEGG   REACTION: R01249
Entry
R01249                      Reaction                               
Name
L-proline:NADP+ 2-oxidoreductase
Definition
L-Proline + NADP+ <=> 1-Pyrroline-2-carboxylate + NADPH + H+
Equation
C00148 + C00006 <=> C03564 + C00005 + C00080
Comment
NAD+ (see R01246)
Reaction class
RC00001  C00005_C00006
RC00135  C00148_C03564
Enzyme
1.5.1.1         1.5.1.21        1.5.1.49
Pathway
rn00330  Arginine and proline metabolism
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.1
     R01249  L-Proline + NADP+ <=> 1-Pyrroline-2-carboxylate + NADPH + H+
    1.5.1.21
     R01249  L-Proline + NADP+ <=> 1-Pyrroline-2-carboxylate + NADPH + H+
    1.5.1.49
     R01249  L-Proline + NADP+ <=> 1-Pyrroline-2-carboxylate + NADPH + H+
Orthology
K19742  1-pyrroline-2-carboxylate reductase [NAD(P)H] [EC:1.5.1.49]
K19743  1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H] [EC:1.5.1.1]
Other DBs
RHEA: 20320
LinkDB

KEGG   RCLASS: RC00135
Entry
RC00135                     RClass                                 
Definition
C1y-C2y:*-*:C1x+C6a+N1x-C1x+C6a+N2x
N1x-N2x:*-*:C1x+C1y-C1x+C2y
Reactant pair
C00148_C03564    C00408_C04092    C00763_C03564
C03440_C04282    C03901_C04445
Related class
Reaction
R01246 R01249 R02201 R02203 R02894 R04221 R04339 R04340
R09496 R11428
Enzyme
1.4.3.3         1.5.1.1         1.5.1.21        1.5.1.25        
1.5.1.49        1.5.99.13       1.5.99.-
Pathway
rn00310  Lysine degradation
rn00330  Arginine and proline metabolism
rn00470  D-Amino acid metabolism
rn00960  Tropane, piperidine and pyridine alkaloid biosynthesis
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
Orthology
K00273  D-amino-acid oxidase [EC:1.4.3.3]
K13609  delta1-piperideine-2-carboxylate reductase [EC:1.5.1.21]
K17851  D-proline dehydrogenase [EC:1.5.99.13]
K19742  1-pyrroline-2-carboxylate reductase [NAD(P)H] [EC:1.5.1.49]
K19743  1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H] [EC:1.5.1.1]
K21060  D-hydroxyproline dehydrogenase [EC:1.5.99.-]
K21061  D-hydroxyproline dehydrogenase subunit beta [EC:1.5.99.-]
K22549  D-hydroxyproline dehydrogenase subunit alpha [EC:1.5.99.-]
K22550  D-hydroxyproline dehydrogenase subunit gamma

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