KEGG   REACTION: R01290
Entry
R01290                      Reaction                               
Name
L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)
Definition
L-Serine + L-Homocysteine <=> L-Cystathionine + H2O
Equation
C00065 + C00155 <=> C02291 + C00001
Comment
multi-step reaction (hydro-lyase, L-homocysteine-lyase)
Reaction class
RC00069  C00155_C02291
RC00489  C00065_C02291
Enzyme
4.2.1.22
Pathway
rn00260  Glycine, serine and threonine metabolism
rn00270  Cysteine and methionine metabolism
rn00670  One carbon pool by folate
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01230  Biosynthesis of amino acids
Module
M00035  Methionine degradation
M00338  Cysteine biosynthesis, homocysteine + serine => cysteine
Brite
Enzymatic reactions [BR:br08201]
 4. Lyase reactions
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.22
     R01290  L-Serine + L-Homocysteine <=> L-Cystathionine + H2O
Orthology
K01697  cystathionine beta-synthase [EC:4.2.1.22]
K10150  cysteine synthase / O-phosphoserine sulfhydrylase / cystathionine beta-synthase [EC:2.5.1.47 2.5.1.65 4.2.1.22]
Other DBs
RHEA: 10115
LinkDB

KEGG   REACTION: R03260
Entry
R03260                      Reaction                               
Name
O-succinyl-L-homoserine succinate-lyase (adding cysteine)
Definition
O-Succinyl-L-homoserine + L-Cysteine <=> L-Cystathionine + Succinate
Equation
C01118 + C00097 <=> C02291 + C00042
Reaction class
RC00020  C00042_C01118
RC00069  C00097_C02291
RC02866  C01118_C02291
Enzyme
2.5.1.48
Pathway
rn00270  Cysteine and methionine metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01230  Biosynthesis of amino acids
Module
M00017  Methionine biosynthesis, aspartate => homoserine => methionine
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.48
     R03260  O-Succinyl-L-homoserine + L-Cysteine <=> L-Cystathionine + Succinate
Orthology
K01739  cystathionine gamma-synthase [EC:2.5.1.48]
Other DBs
RHEA: 20400
LinkDB

KEGG   REACTION: R00891
Entry
R00891                      Reaction                               
Name
L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
Definition
L-Serine + Hydrogen sulfide <=> L-Cysteine + H2O
Equation
C00065 + C00283 <=> C00097 + C00001
Reaction class
RC00256  C00065_C00097
RC02814  C00097_C00283
Enzyme
4.2.1.22
Pathway
rn00260  Glycine, serine and threonine metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 4. Lyase reactions
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.22
     R00891  L-Serine + Hydrogen sulfide <=> L-Cysteine + H2O
Orthology
K01697  cystathionine beta-synthase [EC:4.2.1.22]
K10150  cysteine synthase / O-phosphoserine sulfhydrylase / cystathionine beta-synthase [EC:2.5.1.47 2.5.1.65 4.2.1.22]
LinkDB

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