KEGG   REACTION: R01837
Entry
R01837                      Reaction                               
Name
3beta-hydroxyandrost-5-en-17-one:NAD+ 3-oxidoreductase/delta5-delta-4 isomerase
Definition
Dehydroepiandrosterone + NAD+ <=> Androstenedione + NADH + H+
Equation
C01227 + C00003 <=> C00280 + C00004 + C00080
Comment
NADP+ (see R01839)
Reaction class
RC00001  C00003_C00004
RC00146  C00280_C01227
Enzyme
1.1.1.145       5.3.3.1
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Module
M00110  C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.145
     R01837  Dehydroepiandrosterone + NAD+ <=> Androstenedione + NADH + H+
 5. Isomerase reactions
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.1
     R01837  Dehydroepiandrosterone + NAD+ <=> Androstenedione + NADH + H+
Orthology
K00070  3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1]
Other DBs
RHEA: 43935
LinkDB

KEGG   REACTION: R02216
Entry
R02216                      Reaction                               
Name
pregnenolone:NAD+ 3-oxidoreductase
Definition
Pregnenolone + NAD+ <=> Progesterone + NADH + H+
Equation
C01953 + C00003 <=> C00410 + C00004 + C00080
Comment
3beta-hydroxysteroid dehydrogenase/ Delta5-Delta4-isomerase
two-step reaction
Reaction class
RC00001  C00003_C00004
RC00146  C00410_C01953
Enzyme
1.1.1.145       5.3.3.1
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Module
M00107  Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.145
     R02216  Pregnenolone + NAD+ <=> Progesterone + NADH + H+
 5. Isomerase reactions
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.1
     R02216  Pregnenolone + NAD+ <=> Progesterone + NADH + H+
Orthology
K00070  3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1]
LinkDB

KEGG   REACTION: R02499
Entry
R02499                      Reaction                               
Name
testosterone delta5-delat4-isomerase;
androst-5-ene-3beta,17beta-diol:NAD+ 3-oxidoreductase
Definition
Testosterone + H+ + NADH <=> Androstenediol + NAD+
Equation
C00535 + C00080 + C00004 <=> C04295 + C00003
Comment
NADPH (see R02500)
Reaction class
RC00001  C00003_C00004
RC00146  C00535_C04295
Enzyme
1.1.1.145       5.3.3.1
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.145
     R02499  Testosterone + H+ + NADH <=> Androstenediol + NAD+
 5. Isomerase reactions
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.1
     R02499  Testosterone + H+ + NADH <=> Androstenediol + NAD+
Orthology
K00070  3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1]
LinkDB

KEGG   REACTION: R02840
Entry
R02840                      Reaction                               
Name
cortisol delta5-delat4-isomerase;
11beta,17alpha,21-trihydroxypregnenolone:NAD+ 3-oxidoreductase
Definition
Cortisol + H+ + NADH <=> 11beta,17alpha,21-Trihydroxypregnenolone + NAD+
Equation
C00735 + C00080 + C00004 <=> C05489 + C00003
Comment
NADPH (see R02842)
multi-step reaction (see R03176+R02644)
Reaction class
RC00001  C00003_C00004
RC00146  C00735_C05489
Enzyme
1.1.1.145       5.3.3.1
Pathway
rn00140  Steroid hormone biosynthesis
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.145
     R02840  Cortisol + H+ + NADH <=> 11beta,17alpha,21-Trihydroxypregnenolone + NAD+
 5. Isomerase reactions
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.1
     R02840  Cortisol + H+ + NADH <=> 11beta,17alpha,21-Trihydroxypregnenolone + NAD+
Orthology
K00070  3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1]
LinkDB

KEGG   REACTION: R03327
Entry
R03327                      Reaction                               
Name
17alpha-hydroxypregnenolone:NAD+ 3-oxidoreductase
Definition
17alpha-Hydroxypregnenolone + NAD+ <=> 17alpha-Hydroxyprogesterone + NADH + H+
Equation
C05138 + C00003 <=> C01176 + C00004 + C00080
Comment
NADP+ (see R03328)
multi-step reaction (see R03176+R02644)
Reaction class
RC00001  C00003_C00004
RC00146  C01176_C05138
Enzyme
1.1.1.145       5.3.3.1
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Module
M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.145
     R03327  17alpha-Hydroxypregnenolone + NAD+ <=> 17alpha-Hydroxyprogesterone + NADH + H+
 5. Isomerase reactions
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.1
     R03327  17alpha-Hydroxypregnenolone + NAD+ <=> 17alpha-Hydroxyprogesterone + NADH + H+
Orthology
K00070  3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1]
LinkDB

KEGG   REACTION: R04163
Entry
R04163                      Reaction                               
Name
21-hydroxypregnenolone:NAD+ 3-oxidoreductase
Definition
21-Hydroxypregnenolone + NAD+ <=> 11-Deoxycorticosterone + NADH + H+
Equation
C05485 + C00003 <=> C03205 + C00004 + C00080
Comment
NADP+ (see R04164)
multi-step reaction (see R03176+R02644)
Reaction class
RC00001  C00003_C00004
RC00146  C03205_C05485
Enzyme
1.1.1.145       5.3.3.1
Pathway
rn00140  Steroid hormone biosynthesis
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.145
     R04163  21-Hydroxypregnenolone + NAD+ <=> 11-Deoxycorticosterone + NADH + H+
 5. Isomerase reactions
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.1
     R04163  21-Hydroxypregnenolone + NAD+ <=> 11-Deoxycorticosterone + NADH + H+
Orthology
K00070  3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1]
LinkDB

KEGG   REACTION: R04678
Entry
R04678                      Reaction                               
Name
16alpha-hydroxyandrost-4-ene-3,17-dione delta5-delat4-isomerase;
16alpha-hydroxydehydroepiandrosterone:NAD+ 3-oxidoreductase
Definition
16alpha-Hydroxyandrost-4-ene-3,17-dione + H+ + NADH <=> 16alpha-Hydroxydehydroepiandrosterone + NAD+
Equation
C05140 + C00080 + C00004 <=> C05139 + C00003
Comment
multi-step reaction (see R03176+R02644)
Reaction class
RC00001  C00003_C00004
RC00146  C05139_C05140
Enzyme
1.1.1.145       5.3.3.1
Pathway
rn00140  Steroid hormone biosynthesis
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.145
     R04678  16alpha-Hydroxyandrost-4-ene-3,17-dione + H+ + NADH <=> 16alpha-Hydroxydehydroepiandrosterone + NAD+
 5. Isomerase reactions
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.1
     R04678  16alpha-Hydroxyandrost-4-ene-3,17-dione + H+ + NADH <=> 16alpha-Hydroxydehydroepiandrosterone + NAD+
Orthology
K00070  3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1]
LinkDB

KEGG   REACTION: R04849
Entry
R04849                      Reaction                               
Name
11-deoxycortisol delta5-delat4-isomerase;
17alpha,21-dihydroxypregnenolone:NAD+ 3-oxidoreductase
Definition
11-Deoxycortisol + H+ + NADH <=> 17alpha,21-Dihydroxypregnenolone + NAD+
Equation
C05488 + C00080 + C00004 <=> C05487 + C00003
Comment
multi-step reaction (see R03176+R02644)
Reaction class
RC00001  C00003_C00004
RC00146  C05487_C05488
Enzyme
1.1.1.145       5.3.3.1
Pathway
rn00140  Steroid hormone biosynthesis
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.145
     R04849  11-Deoxycortisol + H+ + NADH <=> 17alpha,21-Dihydroxypregnenolone + NAD+
 5. Isomerase reactions
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.1
     R04849  11-Deoxycortisol + H+ + NADH <=> 17alpha,21-Dihydroxypregnenolone + NAD+
Orthology
K00070  3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1]
LinkDB

KEGG   REACTION: R09920
Entry
R09920                      Reaction                               
Name
cholesterol:NAD+ 3-oxidoreductase;
cholest-4-en-3-one delta5-delat4-isomerase
Definition
Cholesterol + NAD+ <=> Cholest-4-en-3-one + NADH + H+
Equation
C00187 + C00003 <=> C00599 + C00004 + C00080
Comment
multi-step reaction (see R03176+R02644)
Reaction class
RC00001  C00003_C00004
RC00146  C00187_C00599
Enzyme
1.1.1.145       5.3.3.1
Pathway
rn00984  Steroid degradation
rn01120  Microbial metabolism in diverse environments
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.145
     R09920  Cholesterol + NAD+ <=> Cholest-4-en-3-one + NADH + H+
 5. Isomerase reactions
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.1
     R09920  Cholesterol + NAD+ <=> Cholest-4-en-3-one + NADH + H+
Orthology
K16045  3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1]
LinkDB

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