KEGG   REACTION: R01940
Entry
R01940                      Reaction                               
Name
2-oxoadipate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating)
Definition
2-Oxoadipate + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue succinyltransferase] S-glutaryldihydrolipoyllysine + CO2
Equation
C00322 + C15972 <=> C06157 + C00011
Comment
2-oxoadipate dehydrogenase complex: 2-oxoadipate dehydrogenase
a part of multi-step reaction (see R01933, R01940+R02571+R07618)
subsequently R02571
TPP-dependent enzyme (see R13166+R13167)
Reaction class
RC00627  C06157_C15972
RC02833  C00322_C06157
Enzyme
1.2.4.-
Module
M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.4  With a disulfide as acceptor
    1.2.4.-
     R01940  2-Oxoadipate + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue succinyltransferase] S-glutaryldihydrolipoyllysine + CO2
Orthology
K15791  2-oxoadipate dehydrogenase E1 component [EC:1.2.4.-]
Other DBs
RHEA: 12191
LinkDB

KEGG   REACTION: R02571
Entry
R02571                      Reaction                               
Name
glutaryl-CoA:enzyme-N6-(dihydrolipoyl)lysine S-glutaryltransferase
Definition
Glutaryl-CoA + Enzyme N6-(dihydrolipoyl)lysine <=> CoA + [Dihydrolipoyllysine-residue succinyltransferase] S-glutaryldihydrolipoyllysine
Equation
C00527 + C15973 <=> C00010 + C06157
Comment
2-oxoadipate dehydrogenase complex:dihydrolipoyllysine-residue succinyltransferase
a part of multi-step reaction (see R01933, R01940+R02571+R07618)
following after R01940
Reaction class
RC00004  C00010_C00527  C06157_C15973
RC02727  C00527_C06157
Enzyme
2.3.1.61
Pathway
rn00310  Lysine degradation
rn00785  Lipoic acid metabolism
Module
M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.61
     R02571  Glutaryl-CoA + Enzyme N6-(dihydrolipoyl)lysine <=> CoA + [Dihydrolipoyllysine-residue succinyltransferase] S-glutaryldihydrolipoyllysine
Orthology
K00658  2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) [EC:2.3.1.61]
LinkDB

KEGG   REACTION: R07618
Entry
R07618                      Reaction                               
Name
enzyme N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase
Definition
Enzyme N6-(dihydrolipoyl)lysine + NAD+ <=> Enzyme N6-(lipoyl)lysine + NADH + H+
Equation
C15973 + C00003 <=> C15972 + C00004 + C00080
Comment
Oxo-acid dehydrogenase complexes, dihydrolipoyl dehydrogenase
Reaction class
RC00001  C00003_C00004
RC00583  C15972_C15973
Enzyme
1.8.1.4
Pathway
rn00010  Glycolysis / Gluconeogenesis
rn00020  Citrate cycle (TCA cycle)
rn00280  Valine, leucine and isoleucine degradation
rn00310  Lysine degradation
rn00620  Pyruvate metabolism
rn00640  Propanoate metabolism
rn00785  Lipoic acid metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01240  Biosynthesis of cofactors
Module
M00009  Citrate cycle (TCA cycle, Krebs cycle)
M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
M00036  Leucine degradation, leucine => acetoacetate + acetyl-CoA
M00307  Pyruvate oxidation, pyruvate => acetyl-CoA
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.8  Acting on a sulfur group of donors
   1.8.1  With NAD+ or NADP+ as acceptor
    1.8.1.4
     R07618  Enzyme N6-(dihydrolipoyl)lysine + NAD+ <=> Enzyme N6-(lipoyl)lysine + NADH + H+
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.8.1.4
   R08550  [Protein]-N6-[(R)-dihydrolipoyl]-L-lysine <=> Protein N6-(lipoyl)lysine
    R07618  Enzyme N6-(dihydrolipoyl)lysine <=> Enzyme N6-(lipoyl)lysine
Orthology
K00382  dihydrolipoyl dehydrogenase [EC:1.8.1.4]
Other DBs
RHEA: 15048
LinkDB

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