KEGG   REACTION: R07035
Entry
R07035                      Reaction                               
Name
glutathione: 15-HPETE oxidoreductase
Definition
2 Glutathione + 15(S)-HPETE <=> Glutathione disulfide + (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate + H2O
Equation
2 C00051 + C05966 <=> C00127 + C04742 + C00001
Reaction class
RC00011  C00051_C00127
RC00982  C04742_C05966
Enzyme
1.11.1.12
Pathway
rn00590  Arachidonic acid metabolism
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.11  Acting on a peroxide as acceptor
   1.11.1  Peroxidases
    1.11.1.12
     R07035  2 Glutathione + 15(S)-HPETE <=> Glutathione disulfide + (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate + H2O
Orthology
K05361  phospholipid-hydroperoxide glutathione peroxidase [EC:1.11.1.12]
Reference
1  [PMID:30337875]
  Authors
Li C, Deng X, Xie X, Liu Y, Friedmann Angeli JP, Lai L.
  Title
Activation of Glutathione Peroxidase 4 as a Novel Anti-inflammatory Strategy.
  Journal
Front Pharmacol 9:1120 (2018)
DOI:10.3389/fphar.2018.01120
LinkDB

KEGG   RCLASS: RC00982
Entry
RC00982                     RClass                                 
Definition
O1a-O2a:*-O1a:C1c-C1c
Reactant pair
C00427_C05956    C04742_C05966    C04805_C05356
C05965_C14777
Related class
Reaction
R00073 R07034 R07035 R13043
Enzyme
1.11.1.12       1.14.99.1
Pathway
rn00590  Arachidonic acid metabolism
rn01100  Metabolic pathways
Orthology
K00509  prostaglandin-endoperoxide synthase 1 [EC:1.14.99.1]
K05361  phospholipid-hydroperoxide glutathione peroxidase [EC:1.11.1.12]
K11987  prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1]

DBGET integrated database retrieval system