KEGG   REACTION: R09191
Entry
R09191                      Reaction                               
Name
S-adenosyl-L-methionine:4-amino-anhydrotetracycline N-methyltransferase
Definition
4-Amino-anhydrotetracycline + 2 S-Adenosyl-L-methionine <=> Anhydrotetracycline + 2 S-Adenosyl-L-homocysteine
Equation
C06654 + 2 C00019 <=> C02811 + 2 C00021
Reaction class
RC00003  C00019_C00021
RC01515  C02811_C06654
Enzyme
2.1.1.335
Pathway
rn00253  Tetracycline biosynthesis
rn01057  Biosynthesis of type II polyketide products
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00780  Tetracycline/oxytetracycline biosynthesis, pretetramide => tetracycline/oxytetracycline
M00823  Chlortetracycline biosynthesis, pretetramide => chlortetracycline
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.335
     R09191  4-Amino-anhydrotetracycline + 2 S-Adenosyl-L-methionine <=> Anhydrotetracycline + 2 S-Adenosyl-L-homocysteine
Orthology
K14255  4-amino-anhydrotetracycline N4-methyltransferase [EC:2.1.1.335]
Reference
1  [PMID:20522541]
  Authors
Pickens LB, Tang Y
  Title
Oxytetracycline biosynthesis.
  Journal
J Biol Chem 285:27509-15 (2010)
DOI:10.1074/jbc.R110.130419
Reference
2  [PMID:18422316]
  Authors
Zhang W, Watanabe K, Cai X, Jung ME, Tang Y, Zhan J
  Title
Identifying the minimal enzymes required for anhydrotetracycline biosynthesis.
  Journal
J Am Chem Soc 130:6068-9 (2008)
DOI:10.1021/ja800951e
LinkDB

KEGG   RCLASS: RC01515
Entry
RC01515                     RClass                                 
Definition
N1a-N1c:*+*-C1a+C1a:C1y-C1y
Reactant pair
C02811_C06654    C11447_C11461    C11910_C11911
C11925_C11933    C12318_C21073    C18030_C18031
C18033_C18034    C19947_C19948
Related class
Reaction
R06427 R06439 R08929 R08932 R09191 R09821 R11045 R11465
Enzyme
2.1.1.234       2.1.1.235       2.1.1.236       2.1.1.324       
2.1.1.335       2.1.1.-
Pathway
rn00253  Tetracycline biosynthesis
rn00523  Polyketide sugar unit biosynthesis
rn01057  Biosynthesis of type II polyketide products
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01250  Biosynthesis of nucleotide sugars
RModule
RM035  Transamination and N,N-dimethylation in polyketide biosynthesis
Orthology
K13307  dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase [EC:2.1.1.235]
K13311  dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose N,N-dimethyltransferase [EC:2.1.1.234]
K13326  dTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucose/dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose N,N-dimethyltransferase [EC:2.1.1.- 2.1.1.234]
K13330  dTDP-4-amino-2,3,4,6-tetradeoxy-D-glucose N,N-dimethyltransferase [EC:2.1.1.324]
K13332  N,N-dimethyltransferase
K14255  4-amino-anhydrotetracycline N4-methyltransferase [EC:2.1.1.335]
K20682  dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose N,N-dimethyltransferase [EC:2.1.1.236]
K21327  N-methyltransferase [EC:2.1.1.-]

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