KEGG   REACTION: R11478
Entry
R11478                      Reaction                               
Name
tetracycline:FADH2 oxidoreductase (7-halogenating)
Definition
Tetracycline + FADH2 + Cl- + Oxygen + H+ <=> Chlortetracycline + FAD + 2 H2O
Equation
C06570 + C01352 + C00698 + C00007 + C00080 <=> C06571 + C00016 + 2 C00001
Reaction class
RC00949  C06570_C06571
Enzyme
1.14.19.49
Pathway
rn00253  Tetracycline biosynthesis
rn01057  Biosynthesis of type II polyketide products
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00823  Chlortetracycline biosynthesis, pretetramide => chlortetracycline
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.19  With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
    1.14.19.49
     R11478  Tetracycline + FADH2 + Cl- + Oxygen + H+ <=> Chlortetracycline + FAD + 2 H2O
Orthology
K14257  tetracycline 7-halogenase / FADH2 O2-dependent halogenase [EC:1.14.19.49 1.14.19.-]
Other DBs
RHEA: 50715
LinkDB

KEGG   RCLASS: RC00949
Entry
RC00949                     RClass                                 
Definition
C8x-C8y:*-X:C8x+C8y-C8x+C8y
Reactant pair
C00078_C19687    C00082_C02515    C00156_C21850
C00230_C21853    C00530_C06601    C01060_C02515
C01829_C02465    C01829_C07639    C03664_C07088
C06387_C06671    C06570_C06571    C06594_C07092
C06600_C06601    C13620_C13621    C13621_C13622
C13622_C13623    C13623_C13624    C14419_C14450
C16731_C16732    C16732_C16733    C19687_C21868
C20810_C21309    C21109_C21110    C21855_C21856
C21862_C21863
Related class
Reaction
R03539 R03734 R03973 R05267 R05269 R05276 R05505 R06849
R06876 R06877 R06878 R06879 R07230 R07794 R08520 R08521
R09521 R09522 R09570 R11106 R11368 R11478 R12015 R12019
R12022 R12028 R12034
Enzyme
1.11.1.8        1.14.19.9       1.14.19.49      1.14.19.55      
1.14.19.56      1.14.19.57      1.14.19.60      1.14.19.-       
1.21.1.1        1.21.1.2        1.21.99.3       1.21.99.4       
1.97.1.-        2.5.1.-
Pathway
rn00253  Tetracycline biosynthesis
rn00350  Tyrosine metabolism
rn00361  Chlorocyclohexane and chlorobenzene degradation
rn00363  Bisphenol degradation
rn00364  Fluorobenzoate degradation
rn00404  Staurosporine biosynthesis
rn01057  Biosynthesis of type II polyketide products
rn01059  Biosynthesis of enediyne antibiotics
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
Orthology
K00431  thyroid peroxidase [EC:1.11.1.8]
K14257  tetracycline 7-halogenase / FADH2 O2-dependent halogenase [EC:1.14.19.49 1.14.19.-]
K14266  tryptophan 7-halogenase [EC:1.14.19.9]
K15239  2,5-dichlorohydroquinone reductive dechlorinase [EC:2.5.1.-]
K16431  FAD-dependent halogenase [EC:1.14.19.-]
K21185  flavin reductase

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