KEGG   REACTION: R11668
Entry
R11668                      Reaction                               
Name
4-hydroxy-2,2'-bipyrrole-5-methanal:NADP+ oxidoreductase
Definition
4-Hydroxy-2,2'-bipyrrole-5-methanol + NADP+ <=> 4-Hydroxy-2,2'-bipyrrole-5-carbaldehyde + NADPH + H+
Equation
C21568 + C00006 <=> C21569 + C00005 + C00080
Comment
NAD+ (see R11669)
Reaction class
RC00116  C21568_C21569
Pathway
rn00333  Prodigiosin biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00837  Prodigiosin biosynthesis, L-proline => prodigiosin
M00838  Undecylprodigiosin biosynthesis, L-proline => undecylprodigiosin
Orthology
K21785  4-hydroxy-2,2'-bipyrrole-5-methanol dehydrogenase
Reference
1  [PMID:15853884]
  Authors
Williamson NR, Simonsen HT, Ahmed RA, Goldet G, Slater H, Woodley L, Leeper FJ, Salmond GP
  Title
Biosynthesis of the red antibiotic, prodigiosin, in Serratia: identification of a novel 2-methyl-3-n-amyl-pyrrole (MAP) assembly pathway, definition of the terminal condensing enzyme, and implications for undecylprodigiosin biosynthesis in Streptomyces.
  Journal
Mol Microbiol 56:971-89 (2005)
DOI:10.1111/j.1365-2958.2005.04602.x
LinkDB

KEGG   REACTION: R11669
Entry
R11669                      Reaction                               
Name
4-hydroxy-2,2'-bipyrrole-5-methanal:NAD+ oxidoreductase
Definition
4-Hydroxy-2,2'-bipyrrole-5-methanol + NAD+ <=> 4-Hydroxy-2,2'-bipyrrole-5-carbaldehyde + NADH + H+
Equation
C21568 + C00003 <=> C21569 + C00004 + C00080
Comment
NADP+ (see R11668)
Reaction class
RC00116  C21568_C21569
Pathway
rn00333  Prodigiosin biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00837  Prodigiosin biosynthesis, L-proline => prodigiosin
M00838  Undecylprodigiosin biosynthesis, L-proline => undecylprodigiosin
Orthology
K21785  4-hydroxy-2,2'-bipyrrole-5-methanol dehydrogenase
Reference
1  [PMID:15853884]
  Authors
Williamson NR, Simonsen HT, Ahmed RA, Goldet G, Slater H, Woodley L, Leeper FJ, Salmond GP
  Title
Biosynthesis of the red antibiotic, prodigiosin, in Serratia: identification of a novel 2-methyl-3-n-amyl-pyrrole (MAP) assembly pathway, definition of the terminal condensing enzyme, and implications for undecylprodigiosin biosynthesis in Streptomyces.
  Journal
Mol Microbiol 56:971-89 (2005)
DOI:10.1111/j.1365-2958.2005.04602.x
LinkDB

KEGG   RCLASS: RC00116
Entry
RC00116                     RClass                                 
Definition
C1b-C4a:*-*:C8y+O1a-C8y+O4a
Reactant pair
C00018_C00627    C00193_C03485    C00250_C00314
C00261_C00556    C00314_C06051    C00633_C17467
C00755_C06317    C00847_C06050    C02909_C14099
C03067_C03351    C03088_C17206    C05307_C18151
C06576_C06577    C06678_C06679    C06757_C06758
C07209_C07216    C07213_C07214    C11101_C20443
C11101_C20899    C14089_C14090    C14279_C20441
C16540_C16541    C19933_C19934    C21568_C21569
Related class
Reaction
R00278 R01487 R01488 R01491 R01708 R01711 R01763 R01910
R02877 R02993 R04136 R05232 R05271 R05282 R05347 R05348
R06917 R06927 R07154 R08204 R08610 R08914 R08915 R09069
R09070 R09807 R10217 R10218 R10853 R11668 R11669 R12134
Enzyme
1.1.1.1         1.1.1.65        1.1.1.90        1.1.1.91        
1.1.1.97        1.1.1.257       1.1.1.294       1.1.1.-         
1.1.3.7         1.1.3.12        1.1.3.38        1.1.3.42        
1.1.3.47        1.1.99.9        1.1.99.42       1.4.3.5         
1.14.11.6       1.14.13.122     1.17.9.1
Pathway
rn00333  Prodigiosin biosynthesis
rn00365  Furfural degradation
rn00622  Xylene degradation
rn00623  Toluene degradation
rn00626  Naphthalene degradation
rn00627  Aminobenzoate degradation
rn00750  Vitamin B6 metabolism
rn00860  Porphyrin metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
rn01240  Biosynthesis of cofactors
RModule
RM003  Methyl to carboxyl conversion on aromatic ring
Orthology
K00001  alcohol dehydrogenase [EC:1.1.1.1]
K00055  aryl-alcohol dehydrogenase [EC:1.1.1.90]
K00121  S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase [EC:1.1.1.284 1.1.1.1]
K00275  pyridoxamine 5'-phosphate oxidase [EC:1.4.3.5]
K04072  acetaldehyde dehydrogenase / alcohol dehydrogenase [EC:1.2.1.10 1.1.1.1]
K05275  pyridoxine 4-dehydrogenase [EC:1.1.1.65]
K10617  p-cumic alcohol dehydrogenase
K13600  chlorophyllide a oxygenase [EC:1.14.13.122]
K13606  chlorophyll(ide) b reductase [EC:1.1.1.294]
K13953  alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1]
K13954  alcohol dehydrogenase [EC:1.1.1.1]
K18607  pyridoxine 4-oxidase [EC:1.1.3.12]
K18611  4-pyridoxate dehydrogenase [EC:1.1.99.42]
K19629  4-(hydroxymethyl)benzenesulfonate dehydrogenase [EC:1.1.1.257]
K21785  4-hydroxy-2,2'-bipyrrole-5-methanol dehydrogenase
K23998  pyridoxal 5'-phosphate synthase / NAD(P)H-hydrate epimerase [EC:1.4.3.5 5.1.99.6]

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