KEGG   REACTION: R13039
Entry
R13039                      Reaction                               
Definition
Androstan-3alpha,17beta-diol + NAD+ <=> Androsterone + NADH + H+
Equation
C03852 + C00003 <=> C00523 + C00004 + C00080
Comment
hydroxysteroid 17beta dehydrogenase
Reaction class
RC00127  C00523_C03852
Enzyme
1.1.1.51        1.1.1.-
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Module
M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.51
     R13039  Androstan-3alpha,17beta-diol + NAD+ <=> Androsterone + NADH + H+
    1.1.1.-
     R13039  Androstan-3alpha,17beta-diol + NAD+ <=> Androsterone + NADH + H+
Orthology
K04119  aldo-keto reductase family 1 member C3 [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
K25779  hydroxysteroid 17beta dehydrogenase 11 [EC:1.1.1.-]
Reference
1  [PMID:12697717]
  Authors
Chai Z, Brereton P, Suzuki T, Sasano H, Obeyesekere V, Escher G, Saffery R, Fuller P, Enriquez C, Krozowski Z
  Title
17 beta-hydroxysteroid dehydrogenase type XI localizes to human steroidogenic cells.
  Journal
Endocrinology 144:2084-91 (2003)
DOI:10.1210/en.2002-221030
Reference
2  [PMID:10800688]
  Authors
Haeseleer F, Palczewski K.
  Title
Short-chain dehydrogenases/reductases in retina.
  Journal
Methods Enzymol 316:372-83 (2000)
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