KEGG   MODULE: asa_M00051
Entry
asa_M00051        Pathway   Module                                 
Name
De novo pyrimidine biosynthesis, glutamine (+ PRPP) => UMP
Definition
(K11540,(K11541 K01465),((K01954,K01955+K01956) (K00609+K00610,K00608) K01465)) (K00226,K00254,K17828) (K13421,K00762 K01591)
Diagram
asa_M00051  De novo pyrimidine biosynthesis, glutamine (+ PRPP) => UMP
asa_M00051

Class
Pathway modules; Nucleotide metabolism; Pyrimidine metabolism
Pathway
asa00240  Pyrimidine metabolism
asa01240  Biosynthesis of cofactors
asa01100  Metabolic pathways
Organism
Aeromonas salmonicida subsp. salmonicida A449 [GN:asa]
Gene
ASA_0102  pyrE; orotate phosphoribosyltransferase [KO:K00762]
ASA_0227  pyrI; aspartate carbamoyltransferase, regulatory subunit [KO:K00610]
ASA_0228  pyrB; aspartate carbamoyltransferase, catalytic subunit [KO:K00609]
ASA_0323  dho; dihydroorotase [KO:K01465]
ASA_1648  carA; Carbamoylphosphate synthase small subunit [KO:K01956]
ASA_1649  carB; carbamoyl-phosphate synthase, large subunit [KO:K01955]
ASA_1709  pyrC; Dihydroorotase [KO:K01465]
ASA_1772  pyrF; orotidine 5'-phosphate decarboxylase [KO:K01591]
ASA_1993  pyrD; dihydroorotate dehydrogenase [KO:K00254]
Reaction
R00575  
R01397  
R01993  
R01867,R01868,R01869  
R01870  
R00965  
Compound
C00064  L-Glutamine
C00169  Carbamoyl phosphate
C00438  N-Carbamoyl-L-aspartate
C00337  (S)-Dihydroorotate
C00295  Orotate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C01103  Orotidine 5'-phosphate
C00105  UMP
Reference
PMID:34210662
  Authors
Chandel NS
  Title
Nucleotide Metabolism.
  Journal
Cold Spring Harb Perspect Biol 13:a040592 (2021)
DOI:10.1101/cshperspect.a040592
KO module
M00051
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