KEGG   MODULE: M00051
Entry
M00051            Pathway   Module                                 
Name
De novo pyrimidine biosynthesis, glutamine (+ PRPP) => UMP
Definition
(K11540,(K11541 K01465),((K01954,K01955+K01956) (K00609+K00610,K00608) K01465)) (K00226,K00254,K17828) (K13421,K00762 K01591)
Diagram
M00051

Orthology
K11540,K11541,K01954,K01955+K01956  
carbamoyl-phosphate synthase [EC:6.3.5.5] [RN:R00575]
K11540,K11541,K00609+K00610,K00608  
aspartate carbamoyltransferase [EC:2.1.3.2] [RN:R01397]
K11540,K01465  
dihydroorotase [EC:3.5.2.3] [RN:R01993]
K00226  
dihydroorotate dehydrogenase [EC:1.3.98.1] [RN:R01867]
K00254  
dihydroorotate dehydrogenase [EC:1.3.5.2] [RN:R01868]
K17828  
dihydroorotate dehydrogenase [EC:1.3.1.14] [RN:R01869]
K13421,K00762  
orotate phosphoribosyltransferase [EC:2.4.2.10] [RN:R01870]
K13421,K01591  
orotidine-5'-phosphate decarboxylase [EC:4.1.1.23] [RN:R00965]
Class
Pathway modules; Nucleotide metabolism; Pyrimidine metabolism
Pathway
map00240  Pyrimidine metabolism
map01240  Biosynthesis of cofactors
map01100  Metabolic pathways
Reaction
R00575  
R01397  
R01993  
R01867,R01868,R01869  
R01870  
R00965  
Compound
C00064  L-Glutamine
C00169  Carbamoyl phosphate
C00438  N-Carbamoyl-L-aspartate
C00337  (S)-Dihydroorotate
C00295  Orotate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C01103  Orotidine 5'-phosphate
C00105  UMP
Reference
PMID:34210662
  Authors
Chandel NS
  Title
Nucleotide Metabolism.
  Journal
Cold Spring Harb Perspect Biol 13:a040592 (2021)
DOI:10.1101/cshperspect.a040592
LinkDB

DBGET integrated database retrieval system