KEGG   PATHWAY: bbm00290
Entry
bbm00290                    Pathway                                
Name
Valine, leucine and isoleucine biosynthesis - Bordetella bronchiseptica MO149
Class
Metabolism; Amino acid metabolism
Pathway map
bbm00290  Valine, leucine and isoleucine biosynthesis
bbm00290

Module
bbm_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:bbm00290]
bbm_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:bbm00290]
bbm_M00570  Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:bbm00290]
Other DBs
GO: 0009097 0009098 0009099
Organism
Bordetella bronchiseptica MO149 [GN:bbm]
Gene
BN115_0323  [KO:K01652] [EC:2.2.1.6]
BN115_0334  ilvB; putative acetolactate synthase large subunit [KO:K01652] [EC:2.2.1.6]
BN115_0414  leuA; 2-isopropylmalate synthase [KO:K01649] [EC:2.3.3.13]
BN115_0416  ilvD; dihydroxy-acid dehydratase [KO:K01687] [EC:4.2.1.9]
BN115_0538  [KO:K01704] [EC:4.2.1.33 4.2.1.35]
BN115_0539  [KO:K01703] [EC:4.2.1.33 4.2.1.35]
BN115_0717  [KO:K01652] [EC:2.2.1.6]
BN115_0882  [KO:K01652] [EC:2.2.1.6]
BN115_0969  leuB; 3-isopropylmalate dehydrogenase [KO:K00052] [EC:1.1.1.85]
BN115_0970  leuD; 3-isopropylmalate dehydratase small subunit [KO:K01704] [EC:4.2.1.33 4.2.1.35]
BN115_0971  leuC; 3-isopropylmalate dehydratase large subunit [KO:K01703] [EC:4.2.1.33 4.2.1.35]
BN115_1172  [KO:K01652] [EC:2.2.1.6]
BN115_1224  ilvA; threonine dehydratase biosynthetic [KO:K01754] [EC:4.3.1.19]
BN115_1270  [KO:K01754] [EC:4.3.1.19]
BN115_1382  [KO:K01652] [EC:2.2.1.6]
BN115_1386  ilvG; putative acetolactate synthase large subunit [KO:K01652] [EC:2.2.1.6]
BN115_1555  [KO:K01652] [EC:2.2.1.6]
BN115_2017  ilvB; acetolactate synthase large subunit [KO:K01652] [EC:2.2.1.6]
BN115_2326  leuD; 3-isopropylmalate dehydratase small subunit [KO:K01704] [EC:4.2.1.33 4.2.1.35]
BN115_2327  leuC; 3-isopropylmalate dehydratase large subunit [KO:K01703] [EC:4.2.1.33 4.2.1.35]
BN115_2474  ilvG; acetolactate synthase large subunit [KO:K01652] [EC:2.2.1.6]
BN115_2668  ilvD; dihydroxy-acid dehydratase [KO:K01687] [EC:4.2.1.9]
BN115_2904  leuB; 3-isopropylmalate dehydrogenase [KO:K00052] [EC:1.1.1.85]
BN115_2905  leuD; 3-isopropylmalate dehydratase small subunit [KO:K01704] [EC:4.2.1.33 4.2.1.35]
BN115_2906  leuC; 3-isopropylmalate dehydratase large subunit [KO:K01703] [EC:4.2.1.33 4.2.1.35]
BN115_3464  [KO:K00826] [EC:2.6.1.42]
BN115_3494  [KO:K01652] [EC:2.2.1.6]
BN115_3551  tdcB; threonine dehydratase catabolic [KO:K01754] [EC:4.3.1.19]
BN115_3557  ilvC; ketol-acid reductoisomerase [KO:K00053] [EC:1.1.1.86]
BN115_3558  ilvH; acetolactate synthase small subunit [KO:K01653] [EC:2.2.1.6]
BN115_3559  ilvI; acetolactate synthase large subunit [KO:K01652] [EC:2.2.1.6]
BN115_3675  ilvE; branched-chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]
BN115_3774  [KO:K01703] [EC:4.2.1.33 4.2.1.35]
BN115_3775  [KO:K01704] [EC:4.2.1.33 4.2.1.35]
BN115_3898  ilvD; dihydroxy-acid dehydratase [KO:K01687] [EC:4.2.1.9]
BN115_4165  ilvA; threonine dehydratase biosynthetic [KO:K01754] [EC:4.3.1.19]
BN115_4581  leuA; 2-isopropylmalate synthase [KO:K01649] [EC:2.3.3.13]
BN115_4625  [KO:K01652] [EC:2.2.1.6]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00109  2-Oxobutanoate
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00183  L-Valine
C00188  L-Threonine
C00233  4-Methyl-2-oxopentanoate
C00407  L-Isoleucine
C00671  (S)-3-Methyl-2-oxopentanoic acid
C02226  2-Methylmaleate
C02504  alpha-Isopropylmalate
C02612  (R)-2-Methylmalate
C02631  2-Isopropylmaleate
C04181  3-Hydroxy-3-methyl-2-oxobutanoic acid
C04236  (2S)-2-Isopropyl-3-oxosuccinate
C04272  (R)-2,3-Dihydroxy-3-methylbutanoate
C04411  (2R,3S)-3-Isopropylmalate
C06006  (S)-2-Aceto-2-hydroxybutanoate
C06007  (R)-2,3-Dihydroxy-3-methylpentanoate
C06010  (S)-2-Acetolactate
C06032  D-erythro-3-Methylmalate
C14463  (R)-3-Hydroxy-3-methyl-2-oxopentanoate
Reference
PMID:15292141
  Authors
Xu H, Zhang Y, Guo X, Ren S, Staempfli AA, Chiao J, Jiang W, Zhao G.
  Title
Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway.
  Journal
J Bacteriol 186:5400-9 (2004)
DOI:10.1128/JB.186.16.5400-5409.2004
Related
pathway
bbm00260  Glycine, serine and threonine metabolism
bbm00280  Valine, leucine and isoleucine degradation
bbm00620  Pyruvate metabolism
KO pathway
ko00290   

DBGET integrated database retrieval system