KEGG   PATHWAY: ko00290
Entry
ko00290                     Pathway                                
Name
Valine, leucine and isoleucine biosynthesis
Class
Metabolism; Amino acid metabolism
Pathway map
ko00290  Valine, leucine and isoleucine biosynthesis
ko00290

Module
M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:ko00290]
M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:ko00290]
M00535  Isoleucine biosynthesis, pyruvate => 2-oxobutanoate [PATH:ko00290]
M00570  Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:ko00290]
Other DBs
GO: 0009097 0009098 0009099
Orthology
K00052  leuB, IMDH; 3-isopropylmalate dehydrogenase [EC:1.1.1.85]
K00053  ilvC; ketol-acid reductoisomerase [EC:1.1.1.86]
K00263  E1.4.1.9; leucine dehydrogenase [EC:1.4.1.9]
K00826  E2.6.1.42, ilvE; branched-chain amino acid aminotransferase [EC:2.6.1.42]
K00835  avtA; valine--pyruvate aminotransferase [EC:2.6.1.66]
K01649  leuA, IMS; 2-isopropylmalate synthase [EC:2.3.3.13]
K01652  E2.2.1.6L, ilvB, ilvG, ilvI; acetolactate synthase I/II/III large subunit [EC:2.2.1.6]
K01653  E2.2.1.6S, ilvH, ilvN; acetolactate synthase I/III small subunit [EC:2.2.1.6]
K01687  ilvD; dihydroxy-acid dehydratase [EC:4.2.1.9]
K01702  LEU1; 3-isopropylmalate dehydratase [EC:4.2.1.33]
K01703  leuC, IPMI-L; 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit [EC:4.2.1.33 4.2.1.35]
K01704  leuD, IPMI-S; 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit [EC:4.2.1.33 4.2.1.35]
K01754  E4.3.1.19, ilvA, tdcB; threonine dehydratase [EC:4.3.1.19]
K09011  cimA; (R)-citramalate synthase [EC:2.3.3.21]
K11258  ilvM; acetolactate synthase II small subunit [EC:2.2.1.6]
K14260  alaA; alanine-synthesizing transaminase [EC:2.6.1.66 2.6.1.2]
K17989  SDS, SDH, CHA1; L-serine/L-threonine ammonia-lyase [EC:4.3.1.17 4.3.1.19]
K21359  MAM-IS, IPMI2; 3-isopropylmalate/methylthioalkylmalate dehydratase small subunit [EC:4.2.1.33 4.2.1.170]
K21360  MAM-D, IMDH3; 3-isopropylmalate/methylthioalkylmalate dehydrogenase [EC:1.1.1.85 1.1.1.-]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00109  2-Oxobutanoate
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00183  L-Valine
C00188  L-Threonine
C00233  4-Methyl-2-oxopentanoate
C00407  L-Isoleucine
C00671  (S)-3-Methyl-2-oxopentanoic acid
C02226  2-Methylmaleate
C02504  alpha-Isopropylmalate
C02612  (R)-2-Methylmalate
C02631  2-Isopropylmaleate
C04181  3-Hydroxy-3-methyl-2-oxobutanoic acid
C04236  (2S)-2-Isopropyl-3-oxosuccinate
C04272  (R)-2,3-Dihydroxy-3-methylbutanoate
C04411  (2R,3S)-3-Isopropylmalate
C06006  (S)-2-Aceto-2-hydroxybutanoate
C06007  (R)-2,3-Dihydroxy-3-methylpentanoate
C06010  (S)-2-Acetolactate
C06032  D-erythro-3-Methylmalate
C14463  (R)-3-Hydroxy-3-methyl-2-oxopentanoate
Reference
PMID:15292141
  Authors
Xu H, Zhang Y, Guo X, Ren S, Staempfli AA, Chiao J, Jiang W, Zhao G.
  Title
Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway.
  Journal
J Bacteriol 186:5400-9 (2004)
DOI:10.1128/JB.186.16.5400-5409.2004
Related
pathway
ko00260  Glycine, serine and threonine metabolism
ko00280  Valine, leucine and isoleucine degradation
ko00620  Pyruvate metabolism

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