KEGG   PATHWAY: bxe00061
Entry
bxe00061                    Pathway                                
Name
Fatty acid biosynthesis - Paraburkholderia xenovorans LB400
Class
Metabolism; Lipid metabolism
Pathway map
bxe00061  Fatty acid biosynthesis
bxe00061

Module
bxe_M00082  Fatty acid biosynthesis, initiation [PATH:bxe00061]
bxe_M00083  Fatty acid biosynthesis, elongation [PATH:bxe00061]
bxe_M00086  beta-Oxidation, acyl-CoA synthesis [PATH:bxe00061]
Other DBs
GO: 0006633
Organism
Paraburkholderia xenovorans LB400 [GN:bxe]
Gene
Bxe_A1628  acetyl-CoA carboxylase carboxyltransferase subunit alpha [KO:K01962] [EC:6.4.1.2 2.1.3.15]
Bxe_A0532  biotin carboxyl carrier protein [KO:K02160]
Bxe_A0531  Acetyl-CoA carboxylase, biotin carboxylase [KO:K01961] [EC:6.4.1.2 6.3.4.14]
Bxe_B2878  acetyl-CoA carboxylase carboxyltransferase subunit alpha [KO:K01963] [EC:6.4.1.2 2.1.3.15]
Bxe_A1073  [Acyl-carrier-protein] S-malonyltransferase [KO:K00645] [EC:2.3.1.39]
Bxe_A1072  3-oxoacyl-[acyl-carrier-protein] synthase III [KO:K00648] [EC:2.3.1.180]
Bxe_A0098  3-oxoacyl-(acyl-carrier protein) synthase [KO:K00648] [EC:2.3.1.180]
Bxe_A0096  3-oxoacyl-(acyl-carrier protein) synthase [KO:K00648] [EC:2.3.1.180]
Bxe_C0423  Conserved hypothetical protein [KO:K00648] [EC:2.3.1.180]
Bxe_A0937  3-oxoacyl-(acyl-carrier-protein) synthase [KO:K00647] [EC:2.3.1.41]
Bxe_A0941  3-oxoacyl-[acyl-carrier-protein] synthase I [KO:K00647] [EC:2.3.1.41]
Bxe_A1076  3-oxoacyl-[acyl-carrier-protein] synthase II [KO:K09458] [EC:2.3.1.179]
Bxe_A0940  3-oxoacyl-(acyl-carrier-protein) synthase II [KO:K09458] [EC:2.3.1.179]
Bxe_B2728  Putative 3-oxoacyl-acyl carrier protein reductase [KO:K00059] [EC:1.1.1.100]
Bxe_A2099  Putative short-chain dehydrogenase/reductase, TsaC-like protein [KO:K00059] [EC:1.1.1.100]
Bxe_B0266  putative short-chain dehydrogenase [KO:K00059] [EC:1.1.1.100]
Bxe_B2157  Putative short-chain dehydrogenase/reductase SDR [KO:K00059] [EC:1.1.1.100]
Bxe_C0589  Putative short-chain dehydrogenase/reductase [KO:K00059] [EC:1.1.1.100]
Bxe_C0591  Putative short-chain dehydrogenase/reductase [KO:K00059] [EC:1.1.1.100]
Bxe_C0616  Putative short-chain dehydrogenase/reductase [KO:K00059] [EC:1.1.1.100]
Bxe_C0900  Putative short-chain dehydrogenase/reductase [KO:K00059] [EC:1.1.1.100]
Bxe_B2694  Putative 3-oxoacyl-(acyl-carrier-protein) reductase [KO:K00059] [EC:1.1.1.100]
Bxe_A3402  Putative short chain dehydrogenase [KO:K00059] [EC:1.1.1.100]
Bxe_A3257  Putative 3-oxoacyl-acyl carrier protein reductase [KO:K00059] [EC:1.1.1.100]
Bxe_A1074  3-oxoacyl-[acyl-carrier-protein] reductase [KO:K00059] [EC:1.1.1.100]
Bxe_A3012  Putative short-chain dehydrogenase [KO:K00059] [EC:1.1.1.100]
Bxe_A2692  Putative short chain dehydrogenase [KO:K00059] [EC:1.1.1.100]
Bxe_A2114  Putative short-chain dehydrogenase/reductase SDR [KO:K00059] [EC:1.1.1.100]
Bxe_A0939  3-oxoacyl-(acyl-carrier-protein) reductase [KO:K00059] [EC:1.1.1.100]
Bxe_A2775  Putative 3-oxoacyl-(Acyl-carrier-protein)reductase transmembrane protein [KO:K00059] [EC:1.1.1.100]
Bxe_A4098  Putative short-chain dehydrogenase/reductase SDR [KO:K00059] [EC:1.1.1.100]
Bxe_A3610  Putative dehydrogenase [KO:K00059] [EC:1.1.1.100]
Bxe_A3531  Putative short-chain dehydrogenase [KO:K00059] [EC:1.1.1.100]
Bxe_B2664  Putative short-chain type dehydrogenase/reductase [KO:K00059] [EC:1.1.1.100]
Bxe_A1693  3-hydroxyacyl-[acyl-carrier-protein] dehydratase [KO:K02372] [EC:4.2.1.59]
Bxe_B0338  3-hydroxyacyl-[acyl-carrier-protein] dehydratase / 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase [KO:K02372] [EC:4.2.1.59]
Bxe_A1635  Enoyl-[acyl-carrier-protein] reductase (NADH) [KO:K00208] [EC:1.3.1.9 1.3.1.10]
Bxe_B0355  Enoyl-[acyl-carrier-protein] reductase (NADH) [KO:K00208] [EC:1.3.1.9 1.3.1.10]
Bxe_C0050  Enoyl-[acyl-carrier-protein] reductase (NADH) [KO:K00208] [EC:1.3.1.9 1.3.1.10]
Bxe_A2198  Hypothetical short-chain alcohol dehydrogenase [KO:K00209] [EC:1.3.1.9 1.3.1.44]
Bxe_C0318  Putative AMP-dependent synthetase and ligase [KO:K01897] [EC:6.2.1.3]
Bxe_C0867  Putative AMP-dependent synthetase and ligase [KO:K01897] [EC:6.2.1.3]
Bxe_B2539  Putative acyl-CoA synthetase [KO:K01897] [EC:6.2.1.3]
Bxe_A2778  Putative long chain fatty-acid CoA \ligase(Long-chain acyl-CoA synthetase) [KO:K01897] [EC:6.2.1.3]
Bxe_A2746  Putative long chain fatty acid CoA ligase [KO:K01897] [EC:6.2.1.3]
Bxe_A0474  Putative long-chain-fatty-acid-CoA-ligase, FadD [KO:K01897] [EC:6.2.1.3]
Compound
C00024  Acetyl-CoA
C00083  Malonyl-CoA
C00154  Palmitoyl-CoA
C00173  Acyl-[acyl-carrier protein]
C00229  Acyl-carrier protein
C00249  Hexadecanoic acid
C00383  Malonate
C00638  Long-chain fatty acid
C00685  3-Oxoacyl-[acyl-carrier protein]
C00693  trans-2,3-Dehydroacyl-[acyl-carrier protein]
C00712  (9Z)-Octadecenoic acid
C01203  Oleoyl-[acyl-carrier protein]
C01209  Malonyl-[acyl-carrier protein]
C01271  (3R)-3-Hydroxyacyl-[acyl-carrier protein]
C01530  Octadecanoic acid
C01571  Decanoic acid
C02679  Dodecanoic acid
C02843  Long-chain acyl-CoA
C03939  Acetyl-[acyl-carrier protein]
C04088  Octadecanoyl-[acyl-carrier protein]
C04180  cis-Dec-3-enoyl-[acp]
C04246  But-2-enoyl-[acyl-carrier protein]
C04618  (3R)-3-Hydroxybutanoyl-[acyl-carrier protein]
C04619  (3R)-3-Hydroxydecanoyl-[acyl-carrier protein]
C04620  (3R)-3-Hydroxyoctanoyl-[acyl-carrier protein]
C04633  (3R)-3-Hydroxypalmitoyl-[acyl-carrier protein]
C04688  (3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein]
C05223  Dodecanoyl-[acyl-carrier protein]
C05744  Acetoacetyl-[acp]
C05745  Butyryl-[acp]
C05746  3-Oxohexanoyl-[acp]
C05747  (3R)-3-Hydroxyhexanoyl-[acyl-carrier protein]
C05748  trans-Hex-2-enoyl-[acp]
C05749  Hexanoyl-[acp]
C05750  3-Oxooctanoyl-[acp]
C05751  trans-Oct-2-enoyl-[acp]
C05752  Octanoyl-[acp]
C05753  3-Oxodecanoyl-[acp]
C05754  trans-Dec-2-enoyl-[acp]
C05755  Decanoyl-[acp]
C05756  3-Oxododecanoyl-[acp]
C05757  (3R)-3-Hydroxydodecanoyl-[acyl-carrier protein]
C05758  trans-Dodec-2-enoyl-[acp]
C05759  3-Oxotetradecanoyl-[acp]
C05760  trans-Tetradec-2-enoyl-[acp]
C05761  Tetradecanoyl-[acp]
C05762  3-Oxohexadecanoyl-[acp]
C05763  trans-Hexadec-2-enoyl-[acp]
C05764  Hexadecanoyl-[acp]
C06423  Octanoic acid
C06424  Tetradecanoic acid
C08362  (9Z)-Hexadecenoic acid
C16219  3-Oxostearoyl-[acp]
C16220  (3R)-3-Hydroxyoctadecanoyl-[acyl-carrier protein]
C16221  (2E)-Octadecenoyl-[acp]
C16520  Hexadecenoyl-[acyl-carrier protein]
C20683  Long-chain acyl-[acyl-carrier protein]
C20794  n-7 Unsaturated acyl-[acyl-carrier protein]
Reference
  Authors
Salas JJ, Ohlrogge JB.
  Title
Characterization of substrate specificity of plant FatA and FatB acyl-ACP thioesterases.
  Journal
Arch Biochem Biophys 403:25-34 (2002)
DOI:10.1016/S0003-9861(02)00017-6
Reference
  Authors
Zhang YM, Marrakchi H, White SW, Rock CO.
  Title
The application of computational methods to explore the diversity and structure of bacterial fatty acid synthase.
  Journal
J Lipid Res 44:1-10 (2003)
DOI:10.1194/jlr.R200016-JLR200
Reference
  Authors
Voelker T, Kinney AJ.
  Title
VARIATIONS IN THE BIOSYNTHESIS OF SEED-STORAGE LIPIDS.
  Journal
Annu Rev Plant Physiol Plant Mol Biol 52:335-361 (2001)
DOI:10.1146/annurev.arplant.52.1.335
Reference
  Authors
Barker GC, Larson TR, Graham IA, Lynn JR, King GJ.
  Title
Novel insights into seed fatty acid synthesis and modification pathways from genetic diversity and quantitative trait Loci analysis of the Brassica C genome.
  Journal
Plant Physiol 144:1827-42 (2007)
DOI:10.1104/pp.107.096172
Reference
  Authors
Bowman CE, Wolfgang MJ
  Title
Role of the malonyl-CoA synthetase ACSF3 in mitochondrial metabolism.
  Journal
Adv Biol Regul 71:34-40 (2019)
DOI:10.1016/j.jbior.2018.09.002
Reference
  Authors
Venkatesan R, Sah-Teli SK, Awoniyi LO, Jiang G, Prus P, Kastaniotis AJ, Hiltunen JK, Wierenga RK, Chen Z
  Title
Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase.
  Journal
Nat Commun 5:4805 (2014)
DOI:10.1038/ncomms5805
Reference
  Authors
Hiltunen JK, Chen Z, Haapalainen AM, Wierenga RK, Kastaniotis AJ
  Title
Mitochondrial fatty acid synthesis--an adopted set of enzymes making a pathway of major importance for the cellular metabolism.
  Journal
Prog Lipid Res 49:27-45 (2010)
DOI:10.1016/j.plipres.2009.08.001
Reference
  Authors
Kastaniotis AJ, Autio KJ, Keratar JM, Monteuuis G, Makela AM, Nair RR, Pietikainen LP, Shvetsova A, Chen Z, Hiltunen JK
  Title
Mitochondrial fatty acid synthesis, fatty acids and mitochondrial physiology.
  Journal
Biochim Biophys Acta Mol Cell Biol Lipids 1862:39-48 (2017)
DOI:10.1016/j.bbalip.2016.08.011
Related
pathway
bxe00020  Citrate cycle (TCA cycle)
bxe00071  Fatty acid degradation
bxe00410  beta-Alanine metabolism
bxe00561  Glycerolipid metabolism
bxe00564  Glycerophospholipid metabolism
bxe00620  Pyruvate metabolism
bxe00785  Lipoic acid metabolism
KO pathway
ko00061   
LinkDB

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