KEGG   PATHWAY: cabk00290
Entry
cabk00290                   Pathway                                
Name
Valine, leucine and isoleucine biosynthesis - Caballeronia sp. NK8
Class
Metabolism; Amino acid metabolism
Pathway map
cabk00290  Valine, leucine and isoleucine biosynthesis
cabk00290

Module
cabk_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:cabk00290]
cabk_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:cabk00290]
cabk_M00570  Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:cabk00290]
Other DBs
GO: 0009097 0009098 0009099
Organism
Caballeronia sp. NK8 [GN:cabk]
Gene
NK8_02230  leuA; 2-isopropylmalate synthase [KO:K01649] [EC:2.3.3.13]
NK8_02820  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
NK8_05290  [KO:K00826] [EC:2.6.1.42]
NK8_06570  ilvD; dihydroxy-acid dehydratase [KO:K01687] [EC:4.2.1.9]
NK8_13620  [KO:K14260] [EC:2.6.1.66 2.6.1.2]
NK8_13730  [KO:K01754] [EC:4.3.1.19]
NK8_17790  [KO:K01649] [EC:2.3.3.13]
NK8_18480  ilvC; ketol-acid reductoisomerase [KO:K00053] [EC:1.1.1.86]
NK8_18490  ilvN; acetolactate synthase small subunit [KO:K01653] [EC:2.2.1.6]
NK8_18500  [KO:K01652] [EC:2.2.1.6]
NK8_27560  [KO:K01652] [EC:2.2.1.6]
NK8_30510  leuC; 3-isopropylmalate dehydratase large subunit [KO:K01703] [EC:4.2.1.33 4.2.1.35]
NK8_30520  leuD; 3-isopropylmalate dehydratase small subunit [KO:K01704] [EC:4.2.1.33 4.2.1.35]
NK8_30530  leuB; 3-isopropylmalate dehydrogenase [KO:K00052] [EC:1.1.1.85]
NK8_38230  eutB; hydroxyectoine utilization dehydratase EutB [KO:K01754] [EC:4.3.1.19]
NK8_43410  [KO:K01652] [EC:2.2.1.6]
NK8_45260  [KO:K01652] [EC:2.2.1.6]
NK8_45340  [KO:K01652] [EC:2.2.1.6]
NK8_49620  leuC; 3-isopropylmalate dehydratase large subunit [KO:K01703] [EC:4.2.1.33 4.2.1.35]
NK8_49630  leuD; 3-isopropylmalate dehydratase small subunit [KO:K01704] [EC:4.2.1.33 4.2.1.35]
NK8_55670  [KO:K01703] [EC:4.2.1.33 4.2.1.35]
NK8_56260  leuC; 3-isopropylmalate dehydratase large subunit [KO:K01703] [EC:4.2.1.33 4.2.1.35]
NK8_56270  leuD; 3-isopropylmalate dehydratase small subunit [KO:K01704] [EC:4.2.1.33 4.2.1.35]
NK8_57330  [KO:K00826] [EC:2.6.1.42]
NK8_57340  [KO:K01649] [EC:2.3.3.13]
NK8_65450  ilvB; biosynthetic-type acetolactate synthase large subunit [KO:K01652] [EC:2.2.1.6]
NK8_69570  [KO:K01704] [EC:4.2.1.33 4.2.1.35]
NK8_72770  [KO:K01652] [EC:2.2.1.6]
NK8_75930  leuC; 3-isopropylmalate dehydratase large subunit [KO:K01703] [EC:4.2.1.33 4.2.1.35]
NK8_75940  leuD; 3-isopropylmalate dehydratase small subunit [KO:K01704] [EC:4.2.1.33 4.2.1.35]
NK8_75950  leuB; 3-isopropylmalate dehydrogenase [KO:K00052] [EC:1.1.1.85]
NK8_77010  [KO:K01652] [EC:2.2.1.6]
NK8_77420  ilvD; dihydroxy-acid dehydratase [KO:K01687] [EC:4.2.1.9]
NK8_82040  [KO:K01652] [EC:2.2.1.6]
NK8_82190  [KO:K01652] [EC:2.2.1.6]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00109  2-Oxobutanoate
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00183  L-Valine
C00188  L-Threonine
C00233  4-Methyl-2-oxopentanoate
C00407  L-Isoleucine
C00671  (S)-3-Methyl-2-oxopentanoic acid
C02226  2-Methylmaleate
C02504  alpha-Isopropylmalate
C02612  (R)-2-Methylmalate
C02631  2-Isopropylmaleate
C04181  3-Hydroxy-3-methyl-2-oxobutanoic acid
C04236  (2S)-2-Isopropyl-3-oxosuccinate
C04272  (R)-2,3-Dihydroxy-3-methylbutanoate
C04411  (2R,3S)-3-Isopropylmalate
C06006  (S)-2-Aceto-2-hydroxybutanoate
C06007  (R)-2,3-Dihydroxy-3-methylpentanoate
C06010  (S)-2-Acetolactate
C06032  D-erythro-3-Methylmalate
C14463  (R)-3-Hydroxy-3-methyl-2-oxopentanoate
Reference
PMID:15292141
  Authors
Xu H, Zhang Y, Guo X, Ren S, Staempfli AA, Chiao J, Jiang W, Zhao G.
  Title
Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway.
  Journal
J Bacteriol 186:5400-9 (2004)
DOI:10.1128/JB.186.16.5400-5409.2004
Related
pathway
cabk00260  Glycine, serine and threonine metabolism
cabk00280  Valine, leucine and isoleucine degradation
cabk00620  Pyruvate metabolism
KO pathway
ko00290   

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