KEGG   PATHWAY: cdk03015
Entry
cdk03015                    Pathway                                
Name
mRNA surveillance pathway - Camelus dromedarius (Arabian camel)
Description
The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
Class
Genetic Information Processing; Translation
Pathway map
cdk03015  mRNA surveillance pathway
cdk03015

Other DBs
GO: 0071028
Organism
Camelus dromedarius (Arabian camel) [GN:cdk]
Gene
105084259  PELO; protein pelota homolog [KO:K06965]
105084491  WDR33; pre-mRNA 3' end processing protein WDR33 isoform X2 [KO:K15542]
105085129  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
105085282  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X3 [KO:K11583]
105085498  CSTF2; cleavage stimulation factor subunit 2 isoform X1 [KO:K14407]
105085517  PABPC5; polyadenylate-binding protein 5 [KO:K13126]
105086045  [KO:K13126]
105086205  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
105086389  PYM1; partner of Y14 and mago isoform X1 [KO:K14294]
105086464  RNMT; mRNA cap guanine-N7 methyltransferase isoform X1 [KO:K00565] [EC:2.1.1.56]
105087074  PABPC4L; polyadenylate-binding protein 4-like [KO:K13126]
105087521  DDX39B; spliceosome RNA helicase DDX39B [KO:K12812] [EC:5.6.2.7]
105087814  PABPC1L; polyadenylate-binding protein 1-like isoform X1 [KO:K13126]
105088611  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
105089031  GSPT1; eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform X1 [KO:K03267]
105090279  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
105090536  PABPC1; polyadenylate-binding protein 1 isoform X1 [KO:K13126]
105090716  ETF1; eukaryotic peptide chain release factor subunit 1 [KO:K03265]
105090779  MAGOH; protein mago nashi homolog [KO:K12877]
105091147  SMG1; serine/threonine-protein kinase SMG1 isoform X1 [KO:K08873] [EC:2.7.11.1]
105091234  CPSF3; cleavage and polyadenylation specificity factor subunit 3 isoform X2 [KO:K14403] [EC:3.1.27.-]
105091509  NXF1; nuclear RNA export factor 1 [KO:K14284]
105092005  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
105092029  HBS1L; HBS1-like protein isoform X1 [KO:K14416]
105092126  PNN; pinin [KO:K13114]
105092571  GLE1; nucleoporin GLE1 isoform X1 [KO:K18723]
105093186  NXT2; NTF2-related export protein 2 isoform X2 [KO:K14285]
105093474  WDR82; LOW QUALITY PROTEIN: WD repeat-containing protein 82 [KO:K14962]
105093939  UPF3B; regulator of nonsense transcripts 3B isoform X2 [KO:K14328]
105094015  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
105094168  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
105094223  MAGOHB; protein mago nashi homolog 2 [KO:K12877]
105094429  SMG6; telomerase-binding protein EST1A isoform X1 [KO:K11124] [EC:3.1.-.-]
105094881  CPSF7; LOW QUALITY PROTEIN: cleavage and polyadenylation specificity factor subunit 7 [KO:K14398]
105095430  NCBP2L; LOW QUALITY PROTEIN: nuclear cap-binding protein subunit 2-like [KO:K12883]
105095438  SYMPK; symplekin isoform X1 [KO:K06100]
105095465  PAPOLA; poly(A) polymerase alpha isoform X1 [KO:K14376] [EC:2.7.7.19]
105095491  UPF3A; regulator of nonsense transcripts 3A isoform X1 [KO:K14328]
105095541  RNGTT; mRNA-capping enzyme isoform X1 [KO:K13917] [EC:2.7.7.50 3.6.1.74]
105095814  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
105095883  CPSF2; cleavage and polyadenylation specificity factor subunit 2 [KO:K14402]
105096165  NUDT21; cleavage and polyadenylation specificity factor subunit 5 [KO:K14397]
105096224  SMG7; protein SMG7 isoform X1 [KO:K14409]
105096400  SAP18; histone deacetylase complex subunit SAP18 [KO:K14324]
105096982  ACIN1; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
105096986  PABPN1; LOW QUALITY PROTEIN: polyadenylate-binding protein 2 [KO:K14396]
105097237  PAPOLG; poly(A) polymerase gamma isoform X3 [KO:K14376] [EC:2.7.7.19]
105097274  [KO:K13171]
105097638  PCF11; pre-mRNA cleavage complex 2 protein Pcf11 isoform X3 [KO:K14400]
105097709  [KO:K18655] [EC:5.6.2.7]
105097711  [KO:K18655] [EC:5.6.2.7]
105097761  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X2 [KO:K04354]
105097794  MSI2; RNA-binding protein Musashi homolog 2 isoform X1 [KO:K14411]
105098564  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
105098851  CSTF1; cleavage stimulation factor subunit 1 [KO:K14406]
105099026  CASC3; protein CASC3 [KO:K14323]
105099311  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
105099358  CPSF4; cleavage and polyadenylation specificity factor subunit 4 isoform X4 [KO:K14404]
105099706  RNPS1; RNA-binding protein with serine-rich domain 1 isoform X1 [KO:K14325]
105099924  FIP1L1; pre-mRNA 3'-end-processing factor FIP1 isoform X7 [KO:K14405]
105100302  CSTF2T; cleavage stimulation factor subunit 2 tau variant [KO:K14407]
105100314  UPF2; regulator of nonsense transcripts 2 [KO:K14327]
105101081  CPSF6; cleavage and polyadenylation specificity factor subunit 6 isoform X1 [KO:K14398]
105101224  CLP1; polyribonucleotide 5'-hydroxyl-kinase Clp1 [KO:K14399] [EC:2.7.1.78]
105101280  NCBP2; nuclear cap-binding protein subunit 2 [KO:K12883]
105101567  GSPT2; eukaryotic peptide chain release factor GTP-binding subunit ERF3B [KO:K03267]
105101912  UPF1; regulator of nonsense transcripts 1 isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
105101998  MSI1; LOW QUALITY PROTEIN: RNA-binding protein Musashi homolog 1 [KO:K14411]
105102246  NCBP1; nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
105102343  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X2 [KO:K04354]
105102484  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
105102628  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
105103359  PABPC4; polyadenylate-binding protein 4 isoform X3 [KO:K13126]
105103741  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
105104107  DAZAP1; LOW QUALITY PROTEIN: DAZ-associated protein 1 [KO:K14411]
105104241  PAPOLB; poly(A) polymerase beta [KO:K14376] [EC:2.7.7.19]
105104318  CPSF4L; putative cleavage and polyadenylation specificity factor subunit 4-like protein isoform X3 [KO:K14404]
105104430  PPP1CA; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
105104691  PABPN1L; embryonic polyadenylate-binding protein 2 isoform X2 [KO:K14396]
105104992  CPSF1; cleavage and polyadenylation specificity factor subunit 1 isoform X1 [KO:K14401]
105105563  SSU72; LOW QUALITY PROTEIN: RNA polymerase II subunit A C-terminal domain phosphatase SSU72 [KO:K15544] [EC:3.1.3.16]
105105619  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
105105651  SMG5; protein SMG5 isoform X1 [KO:K11125]
105105884  RBM8A; RNA-binding protein 8A isoform X1 [KO:K12876]
105106249  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
105106281  NXT1; NTF2-related export protein 1 isoform X1 [KO:K14285]
105106353  [KO:K14327]
105106390  ALYREF; LOW QUALITY PROTEIN: THO complex subunit 4 [KO:K12881]
105106644  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
105106704  [KO:K13126]
105106728  CSTF3; cleavage stimulation factor subunit 3 [KO:K14408]
105107018  TARDBP; TAR DNA-binding protein 43 [KO:K23600]
116150933  [KO:K13126]
116153486  [KO:K12875]
116154835  [KO:K18655] [EC:5.6.2.7]
116154954  [KO:K18655] [EC:5.6.2.7]
Reference
PMID:15040442
  Authors
Maquat LE
  Title
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.
  Journal
Nat Rev Mol Cell Biol 5:89-99 (2004)
DOI:10.1038/nrm1310
Reference
PMID:16723977
  Authors
Amrani N, Sachs MS, Jacobson A
  Title
Early nonsense: mRNA decay solves a translational problem.
  Journal
Nat Rev Mol Cell Biol 7:415-25 (2006)
DOI:10.1038/nrm1942
Reference
PMID:17183357
  Authors
Eulalio A, Behm-Ansmant I, Izaurralde E
  Title
P bodies: at the crossroads of post-transcriptional pathways.
  Journal
Nat Rev Mol Cell Biol 8:9-22 (2007)
DOI:10.1038/nrm2080
Reference
PMID:18158581
  Authors
Mandel CR, Bai Y, Tong L
  Title
Protein factors in pre-mRNA 3'-end processing.
  Journal
Cell Mol Life Sci 65:1099-122 (2008)
DOI:10.1007/s00018-007-7474-3
Reference
PMID:16715045
  Authors
Clement SL, Lykke-Andersen J
  Title
No mercy for messages that mess with the ribosome.
  Journal
Nat Struct Mol Biol 13:299-301 (2006)
DOI:10.1038/nsmb0406-299
Related
pathway
cdk03013  Nucleocytoplasmic transport
cdk03018  RNA degradation
cdk03040  Spliceosome
KO pathway
ko03015   

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