PATHWAY: ko03015 Help
Entry Name mRNA surveillance pathway
Description The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
Class Genetic Information Processing; TranslationBRITE hierarchy
Pathway map Other DBs Orthology K03265 ETF1, ERF1; peptide chain release factor subunit 1
K03267 ERF3, GSPT; peptide chain release factor subunit 3
K03456 PPP2R1; serine/threonine-protein phosphatase 2A regulatory subunit A
K04354 PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
K04382 PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16 ]
K06269 PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16 ]
K06965 PELO, DOM34, pelA; protein pelota
K11124 SMG6, EST1A; protein SMG6 [EC:3.1.-.-]
K11125 SMG5, EST1B; protein SMG5
K11583 PPP2R3; serine/threonine-protein phosphatase 2A regulatory subunit B''
K11584 PPP2R5; serine/threonine-protein phosphatase 2A regulatory subunit B'
K12595 SKI7; superkiller protein 7
K12812 DDX39B, UAP56, SUB2; ATP-dependent RNA helicase UAP56/SUB2 [EC:5.6.2.7 ]
K12875 ACIN1, ACINUS; apoptotic chromatin condensation inducer in the nucleus
K12876 RBM8A, Y14; RNA-binding protein 8A
K12877 MAGOH; protein mago nashi
K12881 THOC4, ALY; THO complex subunit 4
K12882 NCBP1, CBP80; nuclear cap-binding protein subunit 1
K12883 NCBP2, CBP20; nuclear cap-binding protein subunit 2
K13098 TLS, FUS; RNA-binding protein FUS
K13126 PABPC; polyadenylate-binding protein
K13171 SRRM1, SRM160; serine/arginine repetitive matrix protein 1
K14284 NXF, TAP, MEX67; nuclear RNA export factor
K14285 NXT1_2, P15; NTF2-related export protein 1/2
K14294 WIBG, PYM; partner of Y14 and mago
K14323 CASC3, MLN51; protein CASC3
K14324 SAP18; histone deacetylase complex subunit SAP18
K14325 RNPS1; RNA-binding protein with serine-rich domain 1
K14327 UPF2, RENT2; regulator of nonsense transcripts 2
K14328 UPF3, RENT3; regulator of nonsense transcripts 3
K14396 PABPN1, PABP2; polyadenylate-binding protein 2
K14397 NUDT21, CPSF5, CFIM25; cleavage and polyadenylation specificity factor subunit 5
K14398 CPSF6_7; cleavage and polyadenylation specificity factor subunit 6/7
K14399 CLP1, HERB; polyribonucleotide 5'-hydroxyl-kinase [EC:2.7.1.78 ]
K14400 PCF11; pre-mRNA cleavage complex 2 protein Pcf11
K14401 CPSF1, CFT1; cleavage and polyadenylation specificity factor subunit 1
K14402 CPSF2, CFT2; cleavage and polyadenylation specificity factor subunit 2
K14403 CPSF3, YSH1; cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-]
K14404 CPSF4, YTH1; cleavage and polyadenylation specificity factor subunit 4
K14405 FIP1L1, FIP1; pre-mRNA 3'-end-processing factor FIP1
K14406 CSTF1; cleavage stimulation factor subunit 1
K14407 CSTF2, RNA15; cleavage stimulation factor subunit 2
K14408 CSTF3, RNA14; cleavage stimulation factor subunit 3
K14409 SMG7, EST1C; protein SMG7
K14411 MSI; RNA-binding protein Musashi
K14416 HBS1; elongation factor 1 alpha-like protein
K14543 MTR2; mRNA transport regulator MTR2
K14962 WDR82, SWD2, CPS35; COMPASS component SWD2
K15542 PFS2; polyadenylation factor subunit 2
K15543 REF2; RNA end formation protein 2
K15544 SSU72; RNA polymerase II subunit A C-terminal domain phosphatase SSU72 [EC:3.1.3.16 ]
K18655 DDX19, DBP5; ATP-dependent RNA helicase DDX19/DBP5 [EC:5.6.2.7 ]
K23600 TARDBP, TDP43; TAR DNA-binding protein 43
Reference Authors Maquat LE
Title Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.
Journal Reference Authors Amrani N, Sachs MS, Jacobson A
Title Early nonsense: mRNA decay solves a translational problem.
Journal Reference Authors Eulalio A, Behm-Ansmant I, Izaurralde E
Title P bodies: at the crossroads of post-transcriptional pathways.
Journal Reference Authors Mandel CR, Bai Y, Tong L
Title Protein factors in pre-mRNA 3'-end processing.
Journal Reference Authors Clement SL, Lykke-Andersen J
Title No mercy for messages that mess with the ribosome.
Journal Related ko03013 Nucleocytoplasmic transport
