KEGG ORTHOLOGY: K11124

ORTHOLOGY: K11124

Entry

K11124                      KO

Symbol

SMG6, EST1A

Name

protein SMG6 [EC:3.1.-.-]

Pathway

map03015

mRNA surveillance pathway

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09122 Translation
   03015 mRNA surveillance pathway
    K11124  SMG6, EST1A; protein SMG6
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis
    K11124  SMG6, EST1A; protein SMG6
   03032 DNA replication proteins
    K11124  SMG6, EST1A; protein SMG6
Messenger RNA biogenesis [BR:ko03019]
Eukaryotic type
  mRNA surveillance and transport factors
   Surveillance factors
    Other surveillance factors
     K11124  SMG6, EST1A; protein SMG6
   mRNA cycle factors
    Common to processing body (P body) and stress granule
     K11124  SMG6, EST1A; protein SMG6
DNA replication proteins [BR:ko03032]
Eukaryotic type
  DNA Replication Termination Factors
   Telomerase complex (animals)
    K11124  SMG6, EST1A; protein SMG6

Genes

HSA:	23293(SMG6)

PTR:	454417(SMG6)

PPS:	100983543(SMG6)

GGO:	101130004(SMG6)

PON:	100172632(SMG6)

NLE:	100587229(SMG6)

HMH:	116458468(SMG6)

MCC:	721291(SMG6)

MCF:	102121820(SMG6)

MTHB:

126938849

MNI:	105474287(SMG6)

CSAB:

103242129(SMG6)

CATY:

105584052(SMG6)

TGE:	112609767(SMG6)

MLEU:

105544692(SMG6)

RRO:	104682020(SMG6)

RBB:	108526270(SMG6)

TFN:	117067931(SMG6)

PTEH:

111521378(SMG6)

CANG:

105521762(SMG6)

CJC:	100395317(SMG6)

SBQ:	101044414(SMG6)

CIMI:

108313298(SMG6)

CSYR:

103260576(SMG6)

MMUR:

105857917(SMG6)

LCAT:

123620671(SMG6)

PCOQ:

105817368(SMG6)

OGA:

100953598

MMU:	103677(Smg6)

MCAL:

110304701(Smg6)

MPAH:

110331441(Smg6)

RNO:	287522(Smg6)

MCOC:

116079043(Smg6)

ANU:	117709846(Smg6)

MUN:	110551464(Smg6)

CGE:	100767685(Smg6)

MAUA:

101828623(Smg6)

PROB:

127218908(Smg6)

PLEU:

114691417(Smg6)

MORG:

121456112(Smg6)

MFOT:

126492443

AAMP:

119811283(Smg6)

NGI:	103730528(Smg6)

HGL:	101703882(Smg6)

CPOC:

100715692(Smg6)

CCAN:

109679258 109690019(Smg6)

DORD:

105985837(Smg6)

DSP:	122101901(Smg6)

PLOP:

125365228(Smg6)

NCAR:

124981269

MMMA:

107155191(Smg6)

OCU:

100355820

OPI:	101530140(SMG6)

TUP:	102499463(SMG6)

GVR:	103584780(SMG6)

CFA:	491199(SMG6)

CLUD:

112677544(SMG6)

VVP:	112933099(SMG6)

VLG:	121472968(SMG6)

NPO:	129509599(SMG6)

AML:	100480996(SMG6)

UMR:	103667155(SMG6)

UAH:	113269135(SMG6)

UAR:	123777170(SMG6)

ELK:

111151251

LLV:

125087814

MPUF:

101672678(SMG6)

MNP:	132003529(SMG6)

MLK:	131817042(SMG6)

NVS:	122906335(SMG6)

ORO:	101365921(SMG6)

EJU:	114213796(SMG6)

ZCA:	113939194(SMG6)

MLX:	118025197(SMG6)

LWW:	102729757 102733346

FCA:	101099159(SMG6)

PYU:	121017327(SMG6)

PCOO:

112852522(SMG6)

PBG:	122485101(SMG6)

PVIV:

125151456(SMG6)

LRUF:

124512955

PTG:	102951628(SMG6)

PPAD:

109255124 109255128

PUC:

125926872

AJU:

106983200

HHV:	120245546(SMG6)

BTA:	516411(SMG6)

BOM:	102267758(SMG6)

BIU:	109573618(SMG6)

BBUB:

102389336(SMG6)

BBIS:

105003885(SMG6)

CHX:	102180253(SMG6)

OAS:	101117944(SMG6)

BTAX:

128064558(SMG6)

ODA:	120866210(SMG6)

CCAD:

122447463(SMG6)

MBEZ:

129541491(SMG6)

SSC:	100511407(SMG6)

CFR:	102513178(SMG6)

CBAI:

105071502(SMG6)

CDK:	105094429(SMG6)

VPC:	102545348(SMG6)

BACU:

103002373(SMG6)

BMUS:

118886197(SMG6)

LVE:	103080119(SMG6)

OOR:	101278393(SMG6)

DLE:	111185864(SMG6)

PCAD:

102987480 114483896(SMG6)

PSIU:

116745186(SMG6)

NASI:

112394058(SMG6)

ECB:	100060172(SMG6)

EPZ:	103554992(SMG6)

EAI:	106821978(SMG6)

MYB:	102247118(SMG6)

MYD:	102762748(SMG6)

MMYO:

118671918(SMG6)

MLF:	102434319(SMG6)

PKL:	118702518(SMG6)

EFUS:

103291776(SMG6)

MNA:	107535623(SMG6)

DRO:	112308888(SMG6)

SHON:

119003785(SMG6)

AJM:	119040669(SMG6)

PDIC:

114502286(SMG6)

PHAS:

123817018(SMG6)

MMF:	118633784(SMG6)

PPAM:

129070361(SMG6)

HAI:	109386873(SMG6)

RFQ:	117013254(SMG6)

PALE:

102891022(SMG6)

PGIG:

120621055(SMG6)

PVP:	105291841(SMG6)

RAY:	107507701(SMG6)

MJV:	108391801(SMG6)

TOD:	119230551(SMG6)

SARA:

101537711(SMG6)

SETR:

126020561(SMG6)

LAV:	100661745(SMG6)

TMU:

101360842

ETF:	101640283(SMG6)

DNM:	101412130(SMG6)

MDO:	100013042(SMG6)

GAS:	123246816(SMG6)

SHR:	100929081(SMG6)

AFZ:

127558821

PCW:	110218988 110222158(SMG6)

OAA:	100078566(SMG6)

GGA:	101750600(SMG6)

PCOC:

116228077(SMG6)

MGP:

100541939

CJO:	107322464(SMG6)

TPAI:

128083680(SMG6)

LMUT:

125703118(SMG6)

NMEL:

110407888(SMG6)

APLA:

101800071(SMG6)

ACYG:

106049176(SMG6)

CATA:

118255127(SMG6)

AFUL:

116497323(SMG6)

TGU:	100222348(SMG6)

LSR:	110482088(SMG6)

SCAN:

103820119(SMG6)

PMOA:

120507623(SMG6)

OTC:	121345867(SMG6)

PRUF:

121361582(SMG6)

GFR:	102041469(SMG6)

FAB:	101820889(SMG6)

OMA:	130260765(SMG6)

PHI:	102099402(SMG6)

PMAJ:

107212762(SMG6)

CCAE:

111937752(SMG6)

CCW:	104691064(SMG6)

CBRC:

103621504(SMG6)

ETL:	114060477(SMG6)

ZAB:	102063039(SMG6)

ACHL:

103798512

SVG:	106853325(SMG6)

MMEA:

130582680(SMG6)

HRT:	120761192(SMG6)

FPG:	101916949(SMG6)

FCH:	102051819(SMG6)

CLV:	102093430(SMG6)

EGZ:	104131936(SMG6)

NNI:	104012761(SMG6)

PCRI:

104029919(SMG6)

PLET:

104619620(SMG6)

EHS:	104512853(SMG6)

PCAO:

104051398

ACUN:

113487187(SMG6)

TALA:

104364839(SMG6)

PADL:

103925568(SMG6)

AFOR:

103897969(SMG6)

ACHC:

115347413(SMG6)

HLE:	104835579(SMG6)

AGEN:

GCL:

CCRI:

CSTI:

CMAC:

MUI:

BREG:

GSTE:

104250681(SMG6)

LDI:	104348182(SMG6)

OHA:	104332812(SMG6)

NNT:

104408019

SHAB:

115602135(SMG6)

DPUB:

104302836(SMG6)

PGUU:

104463163(SMG6)

ACAR:

104532404

CPEA:

104386514(SMG6)

AVIT:

104272938

CVF:	104286563(SMG6)

RTD:	128912503(SMG6)

CUCA:

104058644(SMG6)

TEO:

104378624

BRHI:

104493940(SMG6)

AAM:	106484302 106484304

AROW:

112960728(SMG6)

NPD:	112954719(SMG6)

DNE:	112986385(SMG6)

SCAM:

104138013(SMG6)

ASN:	102380384(SMG6)

AMJ:	106737087(SMG6)

CPOO:

109317260

GGN:

109293386

PSS:	102452622(SMG6)

CMY:	102944374(SMG6)

CCAY:

125624030(SMG6)

DCC:	119844470(SMG6)

CPIC:

101943949(SMG6)

TST:	117867566(SMG6)

CABI:

116829458(SMG6)

MRV:	120387497(SMG6)

ACS:	100565727 107983520

ASAO:

132763354(SMG6)

PVT:	110084246(SMG6)

SUND:

121916932(SMG6)

PBI:	103060578 103068124

PMUR:

107296198(SMG6) 107296967

CTIG:

120319403(SMG6)

TSR:

106539513

PGUT:

117669790(SMG6)

APRI:

131188571(SMG6)

PTEX:

113450024(SMG6)

VKO:	123023638(SMG6)

PMUA:

114585383(SMG6)

PRAF:

128402340(SMG6)

ZVI:	118097418(SMG6)

HCG:	128336055(SMG6)

GJA:	107119443(SMG6)

STOW:

125445672(SMG6)

EMC:	129344873(SMG6)

XLA:	108707965(smg6.L)

XTR:	100380118(smg6)

NPR:	108787561(SMG6)

RTEM:

120927581(SMG6)

BBUF:

120994773(SMG6)

BGAR:

122930467(SMG6)

GSH:	117348770(SMG6)

DRE:	100334020(smg6)

SRX:	107728864 107743389

SANH:

107686181 107697428

SGH:	107578000 107589291

CAUA:

113054479

CGIB:

127966498 128021020

PTET:

122352653(smg6)

LROH:

127172088(smg6)

OMC:	131547868(smg6)

PPRM:

120482135(smg6)

RKG:	130074124(smg6)

MAMB:

125262719(smg6)

CIDE:

127520099

MASI:

127432367 127433346

TROS:

130545943(smg6)

TDW:	130411409(smg6)

MANU:

129446758(smg6)

IPU:

108276907

IFU:	128620570(smg6)

PHYP:

113534882(smg6)

SMEO:

124393698(smg6)

TFD:	113638057(smg6)

TVC:	132862945(smg6)

AMEX:

103045565(smg6)

CMAO:

118824511(smg6)

EEE:	113575110(smg6)

CHAR:

105907384(smg6)

TRU:	101071970(smg6)

TFS:	130537532(smg6)

TNG:	GSTEN00029988G001

LCO:	104925819(smg6)

NCC:	104951491 104951498

TBEN:

117490134(smg6)

CGOB:

115018709(smg6)

PGEO:

117458396(smg6)

GACU:

117534431(smg6)

EMAC:

134870858(smg6)

ELY:	117267729(smg6)

EFO:	125898306(smg6)

PLEP:

121952283(smg6)

SLUC:

116037000(smg6)

ECRA:

117955699(smg6)

ESP:	116700920(smg6)

PFLV:

114566500(smg6)

GAT:	120821940(smg6)

PPUG:

119215191(smg6)

AFB:	129113561(smg6)

CLUM:

117742391(smg6)

PSWI:

130190301(smg6)

MSAM:

119895350(smg6)

SCHU:

122888287(smg6)

CUD:	121518682(smg6)

ALAT:

119030891(smg6)

MZE:	101482117(smg6)

ONL:	100702580(smg6)

OAU:	116334031(smg6)

OLA:	101166408(smg6)

OML:	112143075(smg6)

CSAI:

133459630(smg6)

XMA:	102238347(smg6)

XCO:	114153156(smg6)

XHE:	116728389(smg6)

PRET:

103475598(smg6)

PFOR:

103139618(smg6)

PLAI:

106936958(smg6)

PMEI:

106910846(smg6)

GAF:	122844945(smg6)

PPRL:

129373621(smg6)

CVG:	107097637(smg6)

CTUL:

119790279(smg6)

GMU:	124876205(smg6)

NFU:	107386853(smg6)

KMR:	108248491(smg6)

ALIM:

106523503(smg6)

NWH:	119420530(smg6)

AOCE:

111586291(smg6)

MCEP:

125021200(smg6)

CSEM:

103395245(smg6)

POV:	109635825(smg6)

SSEN:

122779651(smg6)

HHIP:

117774198(smg6)

HSP:	118122423(smg6)

SMAU:

118300030(smg6)

LCF:

108893430

SDU:	111217201(smg6)

SLAL:

111662657(smg6)

XGL:	120802342(smg6)

HCQ:	109528875(smg6)

SSCV:

125982493

SBIA:

133492302(smg6)

PEE:	133416176(smg6)

PTAO:

133467033(smg6)

BPEC:

110158534(smg6)

MALB:

109970497(smg6)

BSPL:

114869803(smg6)

SJO:	128371422(smg6)

SASA:

106563799 106603992(smg6) 106603994

STRU:

115155055 115204588

OTW:	112230696 112236493(smg6)

OMY:	110492806(smg6) 110510236

OGO:	124006769 124015322(smg6) 124017838

ONE:	115125415 115146859

OKI:	109873915 109882507

OKE:	118381933 118385722

SALP:

111964039 112071781

SNH:	120021130(smg6) 120056743

CCLU:

121541347 121579101(smg6)

ELS:	105031156(smg6)

SFM:	108932064(smg6)

PKI:	111840281 111847162

AANG:

118235863(smg6)

LOC:	102694323(smg6)

PSPA:

121308661(smg6)

ARUT:

117430915 117964268

PSEX:

120531621(smg6)

LCM:	102360517(SMG6) 102362904

CMK:	103180556(smg6)

CPLA:

122564197(smg6)

HOC:	132830586(smg6)

LERI:

129710636(smg6)

PMRN:

116950153(SMG6)

LRJ:	133348889(SMG6)

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

SKO:

DME:	Dmel_CG6369(Smg6)

DER:

6555447

DSE:

6619632

DSI:	Dsimw501_GD18246(Dsim_GD18246)

DYA:	Dyak_GE10749

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI10551

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

RZE:

AOQ:

TDA:	119678810 119685466

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AAG:	5579825 5579826

AALB:

109424979 109431117

CQU:	CpipJ_CPIJ018772

CPII:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

MDL:

CGLO:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

AROA:

TCA:

DPA:

SOY:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_206062A

BANY:

PMAC:

PPOT:

PXU:

PRAP:

ZCE:	119835197 119835285

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

CCRN:

API:

DNX:

AGS:	114121694 114121699

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM014220 Phum_PHUM014230

FOC:

ZNE:

CSEC:

BROR:

IEL:

DPX:	DAPPUDRAFT_239212

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

PCLA:

PTRU:

EAF:

LSM:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:	107371390 112539873

DPTE:

DFR:

CSCU:

ABRU:

UDV:

SDM:

LPOL:

CEL:	CELE_Y54F10AL.2(smg-6)

CBR:	CBG_15668(Cbr-smg-6)

CRQ:	GCK72_011469

NAI:	NECAME_11161

LOA:	LOAG_00974

TSP:	Tsp_00039a Tsp_12691

LGI:	LOTGIDRAFT_225561

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:	111134286 111135039

CANU:

MYI:

PMAX:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:

SMM:	Smp_131650

SHX:	MS3_00006041(SMG6)

OVI:	T265_00468

EGL:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

TAD:	TRIADDRAFT_59186

AQU:

109580413

CNE:

CNA03070

CNB:

CNBA2970

CNG:	CNAG_07351

CDEU:

CNBG_9025

TASA:

A1Q1_06097

CCAC:

CcaHIS019_0407650(CcaverHIS019_0407650)

TVS:	TRAVEDRAFT_146112

RSX:	RhiXN_03953

CCI:	CC1G_03853

ABP:	AGABI1DRAFT118386(AGABI1DRAFT_118386)

ABV:	AGABI2DRAFT183496(AGABI2DRAFT_183496)

MRR:	Moror_2326

E1B28_008616

SCM:	SCHCO_02606648(SCHCODRAFT_02606648)

CPUT:

CONPUDRAFT_141912

PIF:	PITG_15564

PSOJ:

PHYSODRAFT_502801

SPAR:

SPRG_04472

» show all

Reference

PMID:17053788

Authors

Glavan F, Behm-Ansmant I, Izaurralde E, Conti E

Title

Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex.

Journal

EMBO J 25:5117-25 (2006)
DOI:10.1038/sj.emboj.7601377

Sequence

[hsa:23293]

LinkDB

DBGET integrated database retrieval system