KEGG   PATHWAY: cdm00290
Entry
cdm00290                    Pathway                                
Name
Valine, leucine and isoleucine biosynthesis - Cronobacter dublinensis
Class
Metabolism; Amino acid metabolism
Pathway map
cdm00290  Valine, leucine and isoleucine biosynthesis
cdm00290

Module
cdm_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:cdm00290]
cdm_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:cdm00290]
cdm_M00570  Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:cdm00290]
Other DBs
GO: 0009097 0009098 0009099
Organism
Cronobacter dublinensis [GN:cdm]
Gene
AFK67_01195  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
AFK67_03565  isopropylmalate isomerase [KO:K01703] [EC:4.2.1.33 4.2.1.35]
AFK67_03560  leuD; isopropylmalate isomerase [KO:K01704] [EC:4.2.1.33 4.2.1.35]
AFK67_03570  3-isopropylmalate dehydrogenase [KO:K00052] [EC:1.1.1.85]
AFK67_14575  acetolactate synthase [KO:K01652] [EC:2.2.1.6]
AFK67_03590  acetolactate synthase 3 catalytic subunit [KO:K01652] [EC:2.2.1.6]
AFK67_01175  acetolactate synthase catalytic subunit [KO:K01652] [EC:2.2.1.6]
AFK67_03595  ilvH; acetolactate synthase 3 regulatory subunit [KO:K01653] [EC:2.2.1.6]
AFK67_01180  ilvM; acetolactate synthase 2 regulatory subunit [KO:K11258] [EC:2.2.1.6]
AFK67_01205  ketol-acid reductoisomerase [KO:K00053] [EC:1.1.1.86]
AFK67_01190  dihydroxy-acid dehydratase [KO:K01687] [EC:4.2.1.9]
AFK67_01185  branched-chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]
AFK67_19970  avtA; valine--pyruvate aminotransferase [KO:K00835] [EC:2.6.1.66]
AFK67_14220  aminotransferase [KO:K14260] [EC:2.6.1.66 2.6.1.2]
AFK67_05600  2-isopropylmalate synthase [KO:K01649] [EC:2.3.3.13]
AFK67_03575  2-isopropylmalate synthase [KO:K01649] [EC:2.3.3.13]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00109  2-Oxobutanoate
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00183  L-Valine
C00188  L-Threonine
C00233  4-Methyl-2-oxopentanoate
C00407  L-Isoleucine
C00671  (S)-3-Methyl-2-oxopentanoic acid
C02226  2-Methylmaleate
C02504  alpha-Isopropylmalate
C02612  (R)-2-Methylmalate
C02631  2-Isopropylmaleate
C04181  3-Hydroxy-3-methyl-2-oxobutanoic acid
C04236  (2S)-2-Isopropyl-3-oxosuccinate
C04272  (R)-2,3-Dihydroxy-3-methylbutanoate
C04411  (2R,3S)-3-Isopropylmalate
C06006  (S)-2-Aceto-2-hydroxybutanoate
C06007  (R)-2,3-Dihydroxy-3-methylpentanoate
C06010  (S)-2-Acetolactate
C06032  D-erythro-3-Methylmalate
C14463  (R)-3-Hydroxy-3-methyl-2-oxopentanoate
Reference
  Authors
Xu H, Zhang Y, Guo X, Ren S, Staempfli AA, Chiao J, Jiang W, Zhao G.
  Title
Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway.
  Journal
J Bacteriol 186:5400-9 (2004)
DOI:10.1128/JB.186.16.5400-5409.2004
Related
pathway
cdm00260  Glycine, serine and threonine metabolism
cdm00280  Valine, leucine and isoleucine degradation
cdm00620  Pyruvate metabolism
KO pathway
ko00290   
LinkDB

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