KEGG PATHWAY: dle03450

PATHWAY: dle03450

Entry

dle03450                    Pathway

Name

Non-homologous end-joining - Delphinapterus leucas (beluga whale)

Description

Nonhomologous end joining (NHEJ) eliminates DNA double-strand breaks (DSBs) by direct ligation. NHEJ involves binding of the KU heterodimer to double-stranded DNA ends, recruitment of DNA-PKcs (MRX complex in yeast), processing of ends, and recruitment of the DNA ligase IV (LIG4)-XRCC4 complex, which brings about ligation. A recent study shows that bacteria accomplish NHEJ using just two proteins (Ku and DNA ligase), whereas eukaryotes require many factors. NHEJ repairs DSBs at all stages of the cell cycle, bringing about the ligation of two DNA DSBs without the need for sequence homology, and so is error-prone.

Class

Genetic Information Processing; Replication and repair

Pathway map

dle03450

Non-homologous end-joining

Other DBs

GO:

0006303

Organism

Delphinapterus leucas (beluga whale) [GN:dle]

Gene

111165833

PRKDC; DNA-dependent protein kinase catalytic subunit isoform X1 [KO:K06642] [EC:2.7.11.1]

111167949

MRE11; double-strand break repair protein MRE11 isoform X1 [KO:K10865]

111171807

XRCC5; X-ray repair cross-complementing protein 5 [KO:K10885]

111171840

NHEJ1; non-homologous end-joining factor 1 isoform X1 [KO:K10980]

111172374

POLL; DNA polymerase lambda [KO:K03512] [EC:2.7.7.7 4.2.99.-]

111172631

DNTT; DNA nucleotidylexotransferase isoform X1 [KO:K00977] [EC:2.7.7.31]

111176395

LIG4; DNA ligase 4 [KO:K10777] [EC:6.5.1.1]

111178088

DCLRE1C; protein artemis isoform X1 [KO:K10887] [EC:3.1.-.-]

111182414

RAD50; DNA repair protein RAD50 isoform X1 [KO:K10866] [EC:3.6.-.-]

111183886

FEN1; flap endonuclease 1 [KO:K04799] [EC:3.1.-.-]

111184509

POLM; LOW QUALITY PROTEIN: DNA-directed DNA/RNA polymerase mu [KO:K03513] [EC:2.7.7.7]

111184639

XRCC4; DNA repair protein XRCC4 isoform X1 [KO:K10886]

111186331

XRCC6; X-ray repair cross-complementing protein 6 [KO:K10884]

Reference

PMID:16971555

Authors

Gennery AR.

Title

Primary immunodeficiency syndromes associated with defective DNA double-strand break repair.

Journal

Br Med Bull 77-78:71-85 (2006)
DOI:10.1093/bmb/ldl006

Reference

PMID:17589524

Authors

Zhang Y, Hefferin ML, Chen L, Shim EY, Tseng HM, Kwon Y, Sung P, Lee SE, Tomkinson AE.

Title

Role of Dnl4-Lif1 in nonhomologous end-joining repair complex assembly and suppression of homologous recombination.

Journal

Nat Struct Mol Biol 14:639-46 (2007)
DOI:10.1038/nsmb1261

Reference

PMID:16895466

Authors

Wyman C, Kanaar R.

Title

DNA double-strand break repair: all's well that ends well.

Journal

Annu Rev Genet 40:363-83 (2006)
DOI:10.1146/annurev.genet.40.110405.090451

Reference

PMID:15578053

Authors

Weller GR, Brandt VL, Roth DB.

Title

Doing more with less in bacterial DNA repair.

Journal

Nat Struct Mol Biol 11:1158-9 (2004)
DOI:10.1038/nsmb1204-1158

Reference

PMID:12215643

Authors

Weller GR, Kysela B, Roy R, Tonkin LM, Scanlan E, Della M, Devine SK, Day JP, Wilkinson A, d'Adda di Fagagna F, Devine KM, Bowater RP, Jeggo PA, Jackson SP, Doherty AJ.

Title

Identification of a DNA nonhomologous end-joining complex in bacteria.

Journal

Science 297:1686-9 (2002)
DOI:10.1126/science.1074584

Reference

PMID:17506672

Authors

Pitcher RS, Brissett NC, Doherty AJ.

Title

Nonhomologous end-joining in bacteria: a microbial perspective.

Journal

Annu Rev Microbiol 61:259-82 (2007)
DOI:10.1146/annurev.micro.61.080706.093354

KO pathway

ko03450

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