Entry |
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Symbol |
LIG4, DNL4
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Name |
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Pathway |
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Reaction |
R00381 | (deoxyribonucleotide)n:5'-phospho-(deoxyribonucleotide)m ligase (AMP-forming) |
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Disease |
H00094 | Immunodeficiency associated with DNA repair defects |
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Brite |
KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
09124 Replication and repair
03450 Non-homologous end-joining
K10777 LIG4, DNL4; DNA ligase 4
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03400 DNA repair and recombination proteins
K10777 LIG4, DNL4; DNA ligase 4
Enzymes [BR:ko01000]
6. Ligases
6.5 Forming phosphoric-ester bonds
6.5.1 Ligases that form phosphoric-ester bonds (only sub-subclass identified to date)
6.5.1.1 DNA ligase (ATP)
K10777 LIG4, DNL4; DNA ligase 4
DNA repair and recombination proteins [BR:ko03400]
Eukaryotic type
DSBR (double strand breaks repair)
NHEJ (non-homologous end-joining)
DNA Ligase 4 complex
K10777 LIG4, DNL4; DNA ligase 4
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Other DBs |
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Genes |
» show all
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Reference |
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Authors |
Tseng HM, Tomkinson AE |
Title |
A physical and functional interaction between yeast Pol4 and Dnl4-Lif1 links DNA synthesis and ligation in nonhomologous end joining. |
Journal |
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Reference |
|
Authors |
Chen L, Trujillo K, Sung P, Tomkinson AE |
Title |
Interactions of the DNA ligase IV-XRCC4 complex with DNA ends and the DNA-dependent protein kinase. |
Journal |
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Sequence |
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LinkDB |
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