KEGG ORTHOLOGY: K06642

ORTHOLOGY: K06642

Entry

K06642                      KO

Symbol

PRKDC

Name

DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]

Pathway

map03450

Non-homologous end-joining

map04110

Cell cycle

Disease

H00092

T-B-Severe combined immunodeficiency

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09124 Replication and repair
   03450 Non-homologous end-joining
    K06642  PRKDC; DNA-dependent protein kinase catalytic subunit
09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    K06642  PRKDC; DNA-dependent protein kinase catalytic subunit
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K06642  PRKDC; DNA-dependent protein kinase catalytic subunit
  09182 Protein families: genetic information processing
   03032 DNA replication proteins
    K06642  PRKDC; DNA-dependent protein kinase catalytic subunit
   03400 DNA repair and recombination proteins
    K06642  PRKDC; DNA-dependent protein kinase catalytic subunit
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K06642  PRKDC; DNA-dependent protein kinase catalytic subunit
Protein kinases [BR:ko01001]
Serine/threonine kinases: Other
  PIKK family [OT]
   K06642  PRKDC; DNA-dependent protein kinase catalytic subunit
DNA replication proteins [BR:ko03032]
Eukaryotic type
  DNA Replication Termination Factors
   Other termination factors
    K06642  PRKDC; DNA-dependent protein kinase catalytic subunit
DNA repair and recombination proteins [BR:ko03400]
Eukaryotic type
  DSBR (double strand breaks repair)
   NHEJ (non-homologous end-joining)
    DNA-PK complex
     K06642  PRKDC; DNA-dependent protein kinase catalytic subunit

Other DBs

GO:

0004677

Genes

HSA:	5591(PRKDC)

PTR:	464165(PRKDC)

PPS:	100981342(PRKDC)

GGO:	101128261(PRKDC)

PON:	100460398(PRKDC)

PPYG:

129042304(PRKDC)

NLE:	100586225(PRKDC)

HMH:	116813310(PRKDC)

SSYN:

129486485(PRKDC)

MCC:	708029(PRKDC)

MCF:	102119406(PRKDC)

MTHB:

126960743

MNI:	105496922(PRKDC)

CSAB:

103236758(PRKDC)

CATY:

105592465(PRKDC)

PANU:

100999716(PRKDC)

TGE:	112630683(PRKDC)

MLEU:

105532286(PRKDC)

RRO:	104657634(PRKDC)

RBB:	108535350(PRKDC)

TFN:	117079536(PRKDC)

PTEH:

111525257(PRKDC) 111525260

CANG:

105514376(PRKDC)

CJC:	100399020(PRKDC)

SBQ:	101053589(PRKDC)

CIMI:

108294515(PRKDC)

ANAN:

135278006(PRKDC)

CSYR:

103255463(PRKDC)

MMUR:

105885240(PRKDC)

LCAT:

123644556(PRKDC)

PCOQ:

105824093(PRKDC)

OGA:	100946687(PRKDC)

MMU:	19090(Prkdc)

MCAL:

110311468(Prkdc)

MPAH:

110330004(Prkdc)

RNO:	360748(Prkdc)

MCOC:

116085621(Prkdc)

ANU:	117717846(Prkdc)

MUN:	110561334(Prkdc)

CGE:	100770748(Prkdc)

MAUA:

101824721(Prkdc)

PROB:

127226869(Prkdc)

PLEU:

114709460(Prkdc)

MORG:

121464862(Prkdc)

MFOT:

126490314

AAMP:

119824783(Prkdc)

HGL:	101722248(Prkdc)

CPOC:

100724826(Prkdc)

CCAN:

109688672(Prkdc)

DORD:

105980395(Prkdc)

DSP:	122113064(Prkdc)

PLOP:

125366754(Prkdc)

NCAR:

124981191

MMMA:

107142378(Prkdc)

OCU:	100125348(PRKDC)

OPI:	101519750(PRKDC)

TUP:	102497296(PRKDC)

GVR:	103605498(PRKDC)

CFA:	474176(PRKDC)

CLUD:

112678418(PRKDC)

VVP:	112929152(PRKDC)

VLG:	121498879(PRKDC)

NPO:	129505289(PRKDC)

AML:	100472045(PRKDC)

UMR:	103677407(PRKDC)

UAH:	113268119(PRKDC)

UAR:	123786744(PRKDC)

ELK:

111155445

LLV:

125096736

MPUF:

101687340(PRKDC)

MNP:	132014004(PRKDC)

MLK:	131826853(PRKDC)

NVS:	122904613(PRKDC)

ORO:	101380166(PRKDC)

EJU:	114220887(PRKDC)

ZCA:	113931193(PRKDC)

MLX:	118014796(PRKDC)

NSU:	110578971(PRKDC)

LWW:	102741577(PRKDC)

FCA:	101088389(PRKDC)

PYU:	121038294(PRKDC)

PCOO:

112859375(PRKDC)

PBG:	122495389(PRKDC)

PVIV:

125156297(PRKDC)

LRUF:

124507635

PTG:	102960352(PRKDC)

PPAD:

109254736(PRKDC)

PUC:

125924893

AJU:

106982122

HHV:	120225456(PRKDC)

BTA:	512740(PRKDC)

BOM:	102285992(PRKDC)

BIU:	109568449(PRKDC)

BBUB:

102402820(PRKDC)

BBIS:

104987853(PRKDC)

CHX:	102171625(PRKDC)

OAS:	101111377(PRKDC)

BTAX:

128059433(PRKDC)

ODA:	120878553(PRKDC)

CCAD:

122450836(PRKDC)

MBEZ:

129560536(PRKDC)

SSC:	100156379(PRKDC)

CFR:	102519846(PRKDC)

CBAI:

105063642(PRKDC)

CDK:	105095924(PRKDC)

VPC:	102542127(PRKDC)

BACU:

103019606(PRKDC)

BMUS:

118883282(PRKDC)

LVE:	103090600(PRKDC)

OOR:	101286290(PRKDC)

DLE:	111165833(PRKDC)

PCAD:

102996579(PRKDC)

PSIU:

116742151(PRKDC)

NASI:

112398224(PRKDC)

ECB:	791233(PRKDC)

EPZ:	103567979(PRKDC)

EAI:	106848336(PRKDC)

MYD:	102770810(PRKDC)

MMYO:

118671010(PRKDC)

MLF:	102419064(PRKDC)

MDT:	132219932(PRKDC)

PKL:	118718434(PRKDC)

EFUS:

103287690(PRKDC)

MNA:	107526457(PRKDC)

DRO:	112320750(PRKDC)

SHON:

118979346(PRKDC)

AJM:	119049347(PRKDC)

PDIC:

114501989

PHAS:

123825760(PRKDC)

MMF:	118631854(PRKDC)

PPAM:

129088231(PRKDC)

HAI:	109392680(PRKDC)

RFQ:	117033631(PRKDC)

PALE:

102895801(PRKDC)

PGIG:

120592708(PRKDC)

PVP:	105309245(PRKDC)

RAY:	107503009(PRKDC) 107505079

MJV:	108402211(PRKDC)

TOD:	119241502(PRKDC)

SARA:

101554416(PRKDC)

SETR:

126012011(PRKDC)

LAV:	100667300(PRKDC)

TMU:

101346733

ETF:	101661361(PRKDC)

DNM:	101420469(PRKDC)

MDO:	100030684(PRKDC)

GAS:	123253625(PRKDC)

SHR:	100915132(PRKDC)

AFZ:

127543891

PCW:	110212506(PRKDC)

TVP:	118830241(PRKDC)

OAA:	100084470(PRKDC)

GGA:	395376(PRKDC)

PCOC:

116242252(PRKDC)

MGP:	100546550(PRKDC)

CJO:	107310139(PRKDC)

TPAI:

128091431(PRKDC)

LMUT:

125690334(PRKDC)

NMEL:

110394403(PRKDC)

APLA:

101804792(PRKDC)

ACYG:

106038417(PRKDC)

CATA:

118251234(PRKDC)

AFUL:

116485633(PRKDC)

TGU:	100224961(PRKDC)

LSR:	110473763(PRKDC)

SCAN:

103827354(PRKDC)

PMOA:

120499298(PRKDC)

OTC:	121340193(PRKDC)

PRUF:

121356858(PRKDC)

GFR:	102042450(PRKDC)

FAB:	101819416(PRKDC)

OMA:	130248776(PRKDC)

PHI:	102108488(PRKDC)

PMAJ:

107200430(PRKDC)

CCAE:

111924874(PRKDC)

CCW:	104690434(PRKDC)

CBRC:

103625526(PRKDC)

ETL:	114060600(PRKDC)

ZAB:	102066177(PRKDC)

ZLE:	135444422(PRKDC)

ACHL:

103806799(PRKDC)

SVG:	106851955(PRKDC)

MMEA:

130572951(PRKDC)

HRT:	120755588(PRKDC)

SATI:

136368570(PRKDC)

FPG:	101914535(PRKDC)

FCH:	102045681(PRKDC)

CCRI:

104163073(PRKDC)

NNT:	104402397(PRKDC)

SHAB:

115600619(PRKDC)

ACUN:

113476127(PRKDC)

TALA:

104362484(PRKDC)

ACHC:

115340093(PRKDC)

HALD:

104317668(PRKDC)

HLE:	104836044(PRKDC)

AGEN:

126050212

GCL:

127012553

LDI:	104342155(PRKDC)

MNB:	103781765(PRKDC)

DPUB:

104303091(PRKDC)

AVIT:

104279073(PRKDC)

BRHI:

104493648(PRKDC)

EGZ:	104126877 104127679(PRKDC)

NNI:	104019798(PRKDC)

PCRI:

104031782(PRKDC)

PCAO:

104049890(PRKDC)

PADL:

103923190(PRKDC)

AFOR:

103904238(PRKDC)

FGA:	104081917(PRKDC)

GSTE:

104253554(PRKDC)

CLV:	102099053(PRKDC)

MUI:	104533214(PRKDC)

PGUU:

104466372(PRKDC)

PLET:

104622913(PRKDC)

EHS:	104514897(PRKDC)

CMAC:

104478885(PRKDC)

CUCA:

104059972(PRKDC)

TEO:	104384731(PRKDC)

BREG:

104636170

OHA:	104329161(PRKDC)

ACAR:

104524453(PRKDC)

CPEA:

104396976(PRKDC)

CVF:	104282983(PRKDC)

RTD:	128905305(PRKDC)

AAM:	106494392(PRKDC)

AROW:

112965430(PRKDC)

NPD:	112947422(PRKDC)

TGT:	104573935(PRKDC)

DNE:	112984824(PRKDC)

SCAM:

104149477(PRKDC)

ASN:	102387673(PRKDC)

AMJ:	102575311(PRKDC)

CPOO:

109314867(PRKDC)

GGN:	109298708(PRKDC)

PSS:	102454928(PRKDC)

CMY:	102937565(PRKDC)

CCAY:

125632423(PRKDC)

DCC:	119850474(PRKDC)

CPIC:

101936824(PRKDC)

TST:	117873465(PRKDC)

CABI:

116836465(PRKDC)

MRV:	120399262(PRKDC)

ACS:	100562493(prkdc)

ASAO:

132774808(PRKDC)

PVT:	110077653(PRKDC)

SUND:

121929123(PRKDC)

PBI:	103059879 103061618

PMUR:

107287153(PRKDC)

CTIG:

120303854(PRKDC)

TSR:	106554042(PRKDC)

PGUT:

117672768(PRKDC)

APRI:

131195607(PRKDC)

PTEX:

113435437(PRKDC)

NSS:	113413841(PRKDC)

VKO:	123020429(PRKDC)

PMUA:

114600632(PRKDC)

PRAF:

128417494(PRKDC)

ZVI:	118089778(PRKDC)

HCG:	128324456(PRKDC)

GJA:	107122359(PRKDC)

STOW:

125438905(PRKDC)

EMC:	129333163(PRKDC)

XLA:	373602(prkdc.L)

XTR:	100488663(prkdc)

NPR:	108792226(PRKDC)

RTEM:

120940971(PRKDC)

BBUF:

121002127(PRKDC)

BGAR:

122938497(PRKDC)

MUO:	115477339(PRKDC)

GSH:	117355326(PRKDC)

DRE:	562283(prkdc)

SRX:	107724397 107742141

SANH:

107659432 107684509(prkdc)

SGH:	107591017(prkdc)

CCAR:

109059134 109067843 109092833

CAUA:

113106164(prkdc)

CGIB:

127962738

PTET:

122348579(prkdc)

LROH:

127168194(prkdc)

OMC:	131543536(prkdc)

PPRM:

120493685

RKG:	130083399(prkdc)

MAMB:

125264940(prkdc) 125277589

CIDE:

127515514

CERY:

137031271(prkdc)

MASI:

127451564

TROS:

130552229(prkdc)

TDW:	130440155(prkdc)

MANU:

129446406(prkdc)

IPU:

108268160

IFU:	128609620(prkdc)

PHYP:

113540485(prkdc)

SMEO:

124386883(prkdc)

TFD:	113657371(prkdc)

TVC:	132848405(prkdc)

TRN:	134311879(prkdc)

AMEX:

103028565(prkdc)

CMAO:

118825760(prkdc)

EEE:	113583195(prkdc)

CHAR:

105889280(prkdc)

TRU:	101073073(prkdc)

TFS:	130513579(prkdc)

TNG:	GSTEN00013955G001

LCO:	104928964(prkdc)

NCC:	104943222(prkdc)

TBEN:

117484101(prkdc)

CGOB:

115025495(prkdc)

PGEO:

117465671(prkdc)

GACU:

117543627(prkdc)

EMAC:

134883924(prkdc)

ELY:	117264763(prkdc)

EFO:	125881735(prkdc)

PLEP:

121960509(prkdc)

SLUC:

116055758(prkdc)

ECRA:

117938236(prkdc)

ESP:	116685823(prkdc)

PFLV:

114548975(prkdc)

GAT:	120811646(prkdc)

PPUG:

119198541(prkdc)

AFB:	129110498(prkdc)

CLUM:

117749370(prkdc)

PSWI:

130205973 130206059

MSAM:

119907076(prkdc)

SCHU:

122866791(prkdc)

CUD:	121527198(prkdc)

ALAT:

119008696(prkdc)

MZE:	101484851(prkdc)

ONL:	100706243(prkdc)

OAU:	116335764(prkdc)

OLA:	101171206(prkdc)

OML:	112151428(prkdc)

CSAI:

133422932(prkdc)

XMA:	102221760(prkdc)

XCO:	114137103(prkdc)

XHE:	116711736(prkdc)

PRET:

103482327(prkdc)

PFOR:

103143342(prkdc)

PLAI:

106958239(prkdc)

PMEI:

106914554(prkdc)

GAF:	122824240(prkdc)

PPRL:

129364739(prkdc)

CVG:	107084919(prkdc)

CTUL:

119795987(prkdc)

GMU:	124858125(prkdc)

NFU:	107382641(prkdc)

KMR:	108235234(prkdc)

ALIM:

106517127 106535502

NWH:	119426588(prkdc)

AOCE:

111574562(prkdc)

MCEP:

124995515(prkdc)

CSEM:

103377075(prkdc)

POV:	109629764(prkdc)

SSEN:

122771322(prkdc)

HHIP:

117754282(prkdc)

HSP:	118098382(prkdc)

PPLT:

128425940(prkdc)

SMAU:

118290862(prkdc)

LCF:

108898307

SDU:	111228243(prkdc)

SLAL:

111648260(prkdc)

XGL:	120789644(prkdc)

HCQ:	109507813(prkdc)

SSCV:

125985671

SBIA:

133492673(prkdc)

PEE:	133396847(prkdc)

PTAO:

133469880(prkdc)

BPEC:

110165311(prkdc)

MALB:

109952212(prkdc)

BSPL:

114853392(prkdc)

SJO:	128382532(prkdc)

SASA:

106579558(prkdc)

STRU:

115150674(prkdc)

OTW:	112215359(prkdc)

OMY:	110535300(prkdc)

OGO:	123991347(prkdc)

ONE:	115104906(prkdc)

OKI:	109909835(prkdc)

OKE:	118361744(prkdc)

SALP:

111972800(prkdc)

SNH:	120027880(prkdc)

CCLU:

121549875(prkdc)

ELS:	105019560(prkdc)

SFM:	108919710 114909783

PKI:	111854631(prkdc)

AANG:

118209591(prkdc)

LOC:	102698219(prkdc)

PSPA:

121314412(prkdc)

ARUT:

117435350(prkdc)

PSEX:

120530210(prkdc)

LCM:	102352949(PRKDC)

CMK:	103175370(prkdc)

RTP:	109915842(prkdc)

CPLA:

122549078(prkdc)

HOC:	132815216(prkdc)

LERI:

129696316(prkdc)

BFO:

118428664

BBEL:

109483301

CIN:	100185020 108951125

SCLV:

120340358

SPU:	576405 586799

APLC:

110990343

ARUN:

117292274

SKO:	102808978 102809109

ECOE:

CLON:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ007259

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:	114872009 114872012

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:	100123782 100679075

CSOL:

TPRE:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

CSET:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

API:

DNX:

AGS:

ACOO:

BTAB:

CLEC:

NLU:

FOC:

TPAL:

ZNE:

CSEC:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_333161

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

RSAN:

CSCU:

CVS:

ABRU:

UDV:

PMEO:

TSP:

HRO:	HELRODRAFT_159097

LGI:	LOTGIDRAFT_143667

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

MCAF:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:	106169576 106174393

OVI:	T265_02103

EGL:

EGR_06214

LLON:

135483345

NVE:

5505605

EPA:	110233469 110237713

ATEN:

116309119

ADF:	107328540 107331835 107331836

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:	130640783 130641154

RES:

135687316

TAD:	TRIADDRAFT_20924

AQU:

100633457

PPP:

112286712

VCN:	VOLCADRAFT_87995

CSL:	COCSUDRAFT_63567

OTA:	OT_ostta12g01960

BPG:	Bathy07g02920

RIE:	OCT59_022584

MBR:	MONBRDRAFT_30238

SRE:	PTSG_11836

DDI:	DDB_G0281167(dnapkcs)

DPP:	DICPUDRAFT_150499

DFA:	DFA_11411(dnapkcs)

TET:	TTHERM_00203010

PTM:	GSPATT00007823001

PIF:	PITG_05423

PSOJ:

PHYSODRAFT_296092

SPAR:

SPRG_12566

NGR:	NAEGRDRAFT_57196

» show all

Reference

PMID:12649176

Authors

Soubeyrand S, Pope L, Pakuts B, Hache RJ

Title

Threonines 2638/2647 in DNA-PK are essential for cellular resistance to ionizing radiation.

Journal

Cancer Res 63:1198-201 (2003)

Sequence

[hsa:5591]

LinkDB

DBGET integrated database retrieval system