KEGG   PATHWAY: dme00830
Entry
dme00830                    Pathway                                
Name
Retinol metabolism - Drosophila melanogaster (fruit fly)
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
dme00830  Retinol metabolism
dme00830

Other DBs
GO: 0006776
Organism
Drosophila melanogaster (fruit fly) [GN:dme]
Gene
Dmel_CG10178  Ugt301D1; UDP-glycosyltransferase family 301 member D1, isoform B [KO:K00699] [EC:2.4.1.17]
Dmel_CG10672  Dhrs4; Dehydrogenase/reductase 4 [KO:K11147] [EC:1.1.-.-]
Dmel_CG11012  Ugt37A1; UDP-glycosyltransferase family 37 member A1 [KO:K00699] [EC:2.4.1.17]
Dmel_CG11289  Ugt307A1; UDP-glycosyltransferase family 307 member A1 [KO:K00699] [EC:2.4.1.17]
Dmel_CG13270  Ugt37C2; UDP-glycosyltransferase family 37 member C2, isoform B [KO:K00699] [EC:2.4.1.17]
Dmel_CG13271  Ugt37E1; UDP-glycosyltransferase family 37 member E1 [KO:K00699] [EC:2.4.1.17]
Dmel_CG14946  firl; firelighter, isoform C [KO:K15734] [EC:1.1.1.105]
Dmel_CG15629  CG15629; uncharacterized protein [KO:K15734] [EC:1.1.1.105]
Dmel_CG15661  Ugt49C1; UDP-glycosyltransferase family 49 member C1, isoform B [KO:K00699] [EC:2.4.1.17]
Dmel_CG15902  Ugt304A1; UDP-glycosyltransferase family 304 member A1 [KO:K00699] [EC:2.4.1.17]
Dmel_CG17200  Ugt35E1; UDP-glycosyltransferase family 35 member E1 [KO:K00699] [EC:2.4.1.17]
Dmel_CG17322  Ugt36E1; UDP-glycosyltransferase family 36 member E1, isoform D [KO:K00699] [EC:2.4.1.17]
Dmel_CG17323  Ugt36D1; UDP-glycosyltransferase family 36 member D1, isoform E [KO:K00699] [EC:2.4.1.17]
Dmel_CG17324  Ugt36F1; UDP-glycosyltransferase family 36 member F1 [KO:K00699] [EC:2.4.1.17]
Dmel_CG17932  Ugt37D1; UDP-glycosyltransferase family 37 member D1, isoform C [KO:K00699] [EC:2.4.1.17]
Dmel_CG2254  Ldsdh1; lipid droplet subset dehydrogenase 1 [KO:K15734] [EC:1.1.1.105]
Dmel_CG2788  Ugt36A1; UDP-glycosyltransferase family 36 member A1, isoform B [KO:K00699] [EC:2.4.1.17]
Dmel_CG31002  Ugt35D1; UDP-glycosyltransferase family 35 member D1 [KO:K00699] [EC:2.4.1.17]
Dmel_CG31991  mdy; midway, isoform A [KO:K11155] [EC:2.3.1.20 2.3.1.75 2.3.1.76]
Dmel_CG3481  Adh; alcohol dehydrogenase, isoform C [KO:K00001] [EC:1.1.1.1]
Dmel_CG3797  Ugt316A1; UDP-glycosyltransferase family 316 member A1, isoform B [KO:K00699] [EC:2.4.1.17]
Dmel_CG4302  Ugt49B1; UDP-glycosyltransferase family 49 member B1 [KO:K00699] [EC:2.4.1.17]
Dmel_CG4414  Ugt317A1; UDP-glycosyltransferase family 317 member A1, isoform B [KO:K00699] [EC:2.4.1.17]
Dmel_CG4772  Ugt303A1; UDP-glycosyltransferase family 303 member A1, isoform B [KO:K00699] [EC:2.4.1.17]
Dmel_CG5724  Ugt37A2; UDP-glycosyltransferase family 37 member A2 [KO:K00699] [EC:2.4.1.17]
Dmel_CG5999  Ugt37A3; UDP-glycosyltransferase family 37 member A3 [KO:K00699] [EC:2.4.1.17]
Dmel_CG6475  Ugt49B2; UDP-glycosyltransferase family 49 member B2 [KO:K00699] [EC:2.4.1.17]
Dmel_CG6598  Fdh; formaldehyde dehydrogenase [KO:K00121] [EC:1.1.1.284 1.1.1.1]
Dmel_CG6633  Ugt35C1; UDP-glycosyltransferase family 35 member C1 [KO:K00699] [EC:2.4.1.17]
Dmel_CG6644  Ugt35A1; UDP-glycosyltransferase family 35 member A1 [KO:K00699] [EC:2.4.1.17]
Dmel_CG6653  Ugt35E2; UDP-glycosyltransferase family 35 member E2 [KO:K00699] [EC:2.4.1.17]
Dmel_CG6658  Ugt302K1; UDP-glycosyltransferase family 302 member K1, isoform B [KO:K00699] [EC:2.4.1.17]
Dmel_CG8652  Ugt37C1; UDP-glycosyltransferase family 37 member C1 [KO:K00699] [EC:2.4.1.17]
Dmel_CG9265  CG9265; uncharacterized protein, isoform B [KO:K15734] [EC:1.1.1.105]
Dmel_CG9481  Ugt37B1; UDP-glycosyltransferase family 37 member B1 [KO:K00699] [EC:2.4.1.17]
Compound
C00376  Retinal
C00473  Retinol
C00777  Retinoate
C00778  Rhodopsin
C00899  11-cis-Retinol
C02075  Retinyl ester
C02094  beta-Carotene
C02110  11-cis-Retinal
C02588  Retinyl palmitate
C03455  11-cis-Retinyl palmitate
C05914  Bathorhodopsin
C05915  Lumirhodopsin
C05916  Metarhodopsin
C05917  Iodopsin
C11061  all-trans-Retinoyl-beta-glucuronide
C15492  all-trans-13,14-Dihydroretinol
C15493  9-cis-Retinoic acid
C16677  all-trans-4-Hydroxyretinoic acid
C16678  all-trans-4-Oxoretinoic acid
C16679  all-trans-18-Hydroxyretinoic acid
C16680  all-trans-5,6-Epoxyretinoic acid
C16681  9-cis-Retinal
C16682  9-cis-Retinol
C16683  4-Oxoretinol
C21797  all-trans-3,4-Didehydroretinol
Reference
PMID:16968212
  Authors
Travis GH, Golczak M, Moise AR, Palczewski K.
  Title
Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents.
  Journal
Annu Rev Pharmacol Toxicol 47:469-512 (2007)
DOI:10.1146/annurev.pharmtox.47.120505.105225
Reference
PMID:17618621
  Authors
Muniz A, Villazana-Espinoza ET, Hatch AL, Trevino SG, Allen DM, Tsin AT.
  Title
A novel cone visual cycle in the cone-dominated retina.
  Journal
Exp Eye Res 85:175-84 (2007)
DOI:10.1016/j.exer.2007.05.003
Reference
PMID:11093772
  Authors
Marill J, Cresteil T, Lanotte M, Chabot GG.
  Title
Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.
  Journal
Mol Pharmacol 58:1341-8 (2000)
DOI:10.1124/mol.58.6.1341
Reference
PMID:17893666
  Authors
Nezzar H, Chiambaretta F, Marceau G, Blanchon L, Faye B, Dechelotte P, Rigal D, Sapin V.
  Title
Molecular and metabolic retinoid pathways in the human ocular surface.
  Journal
Mol Vis 13:1641-50 (2007)
Reference
PMID:16688755
  Authors
Blomhoff R, Blomhoff HK.
  Title
Overview of retinoid metabolism and function.
  Journal
J Neurobiol 66:606-30 (2006)
DOI:10.1002/neu.20242
Reference
PMID:16428379
  Authors
Liden M, Eriksson U.
  Title
Understanding retinol metabolism: structure and function of retinol dehydrogenases.
  Journal
J Biol Chem 281:13001-4 (2006)
DOI:10.1074/jbc.R500027200
KO pathway
ko00830   

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