KEGG   PATHWAY: ko00830
Entry
ko00830                     Pathway                                
Name
Retinol metabolism
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
ko00830  Retinol metabolism
ko00830

Other DBs
GO: 0006776
Orthology
K00001  E1.1.1.1, adh; alcohol dehydrogenase [EC:1.1.1.1]
K00061  RDH5; 11-cis-retinol dehydrogenase [EC:1.1.1.315]
K00121  frmA, ADH5, adhC; S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase [EC:1.1.1.284 1.1.1.1]
K00157  AOX; aldehyde oxidase [EC:1.2.3.1]
K00515  BCMO1, BCDO1; beta-carotene 15,15'-dioxygenase [EC:1.13.11.63]
K00678  LRAT; phosphatidylcholine-retinol O-acyltransferase [EC:2.3.1.135]
K00699  UGT; glucuronosyltransferase [EC:2.4.1.17]
K07249  ALDH1A; retinal dehydrogenase [EC:1.2.1.36]
K07408  CYP1A1; cytochrome P450 family 1 subfamily A1 [EC:1.14.14.1]
K07409  CYP1A2; cytochrome P450 family 1 subfamily A2 [EC:1.14.14.1]
K07411  CYP2A; cytochrome P450 family 2 subfamily A [EC:1.14.14.1]
K07412  CYP2B; cytochrome P450 family 2 subfamily B [EC:1.14.14.1]
K07413  CYP2C; cytochrome P450 family 2 subfamily C [EC:1.14.14.1]
K07420  CYP2S1; cytochrome P450 family 2 subfamily S1 [EC:1.14.14.1]
K07423  CYP2W1; cytochrome P450 family 2 subfamily W1 [EC:1.14.14.-]
K07424  CYP3A; cytochrome P450 family 3 subfamily A [EC:1.14.14.1]
K07425  CYP4A; long-chain fatty acid omega-monooxygenase [EC:1.14.14.80]
K07437  CYP26A; cytochrome P450 family 26 subfamily A [EC:1.14.14.-]
K09516  RETSAT; all-trans-retinol 13,14-reductase [EC:1.3.99.23]
K11146  DHRS3; short-chain dehydrogenase/reductase 3 [EC:1.1.1.300]
K11147  DHRS4; dehydrogenase/reductase SDR family member 4 [EC:1.1.-.-]
K11148  DHRS4L2; dehydrogenase/reductase SDR family member 4-like protein 2 [EC:1.1.-.-]
K11149  DHRS9; dehydrogenase/reductase SDR family member 9 [EC:1.1.-.-]
K11150  RDH8; retinol dehydrogenase 8 [EC:1.1.1.-]
K11151  RDH10; retinol dehydrogenase 10 [EC:1.1.1.-]
K11152  RDH11; retinol dehydrogenase 11 [EC:1.1.1.300]
K11153  RDH12; retinol dehydrogenase 12 [EC:1.1.1.300]
K11154  RDH16; retinol dehydrogenase 16 [EC:1.1.1.-]
K11155  DGAT1; diacylglycerol O-acyltransferase 1 [EC:2.3.1.20 2.3.1.75 2.3.1.76]
K11156  DGAT2L4, MFAT, AWAT2; diacylglycerol O-acyltransferase 2-like protein 4 [EC:2.3.1.75 2.3.1.76]
K11157  PNPLA4; patatin-like phospholipase domain-containing protein 4 [EC:3.1.1.-]
K11158  RPE65; retinoid isomerohydrolase / lutein isomerase [EC:3.1.1.64 5.3.3.22]
K11161  RDH13; retinol dehydrogenase 13 [EC:1.1.1.300]
K12664  CYP26B; cytochrome P450 family 26 subfamily B [EC:1.14.14.-]
K12665  CYP26C; cytochrome P450 family 26 subfamily C [EC:1.14.14.-]
K13369  HSD17B6; 17beta-estradiol 17-dehydrogenase / all-trans-retinol dehydrogenase (NAD+) / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) [EC:1.1.1.62 1.1.1.105 1.1.1.239]
K13951  ADH1_7; alcohol dehydrogenase 1/7 [EC:1.1.1.1]
K13952  ADH6; alcohol dehydrogenase 6 [EC:1.1.1.1]
K13953  adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1]
K13980  ADH4; alcohol dehydrogenase 4 [EC:1.1.1.1]
K15734  SDR16C5; all-trans-retinol dehydrogenase (NAD+) [EC:1.1.1.105]
K17683  CYP2A6; cytochrome P450 family 2 subfamily A6 [EC:1.14.14.-]
K17689  CYP3A4; cytochrome P450 family 3 subfamily A4 [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.14.-]
K17690  CYP3A5; cytochrome P450 family 3 subfamily A5 [EC:1.14.14.1]
K17691  CYP3A7; cytochrome P450 family 3 subfamily A7 [EC:1.14.14.1]
K17709  CYP2B6; cytochrome P450 family 2 subfamily B6 [EC:1.14.14.-]
K17718  CYP2C8; cytochrome P450 family 2 subfamily C8 [EC:1.14.14.1]
K17719  CYP2C9; cytochrome P450 family 2 subfamily C9 [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.-]
K17720  CYP2C18; cytochrome P450 family 2 subfamily C18 [EC:1.14.14.1]
K17951  CYP27C1; all-trans-retinol 3,4-desaturase [EC:1.14.19.53]
Compound
C00376  Retinal
C00473  Retinol
C00777  Retinoate
C00778  Rhodopsin
C00899  11-cis-Retinol
C02075  Retinyl ester
C02094  beta-Carotene
C02110  11-cis-Retinal
C02588  Retinyl palmitate
C03455  11-cis-Retinyl palmitate
C05914  Bathorhodopsin
C05915  Lumirhodopsin
C05916  Metarhodopsin
C05917  Iodopsin
C11061  all-trans-Retinoyl-beta-glucuronide
C15492  all-trans-13,14-Dihydroretinol
C15493  9-cis-Retinoic acid
C16677  all-trans-4-Hydroxyretinoic acid
C16678  all-trans-4-Oxoretinoic acid
C16679  all-trans-18-Hydroxyretinoic acid
C16680  all-trans-5,6-Epoxyretinoic acid
C16681  9-cis-Retinal
C16682  9-cis-Retinol
C16683  4-Oxoretinol
C21797  all-trans-3,4-Didehydroretinol
Reference
PMID:16968212
  Authors
Travis GH, Golczak M, Moise AR, Palczewski K.
  Title
Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents.
  Journal
Annu Rev Pharmacol Toxicol 47:469-512 (2007)
DOI:10.1146/annurev.pharmtox.47.120505.105225
Reference
PMID:17618621
  Authors
Muniz A, Villazana-Espinoza ET, Hatch AL, Trevino SG, Allen DM, Tsin AT.
  Title
A novel cone visual cycle in the cone-dominated retina.
  Journal
Exp Eye Res 85:175-84 (2007)
DOI:10.1016/j.exer.2007.05.003
Reference
PMID:11093772
  Authors
Marill J, Cresteil T, Lanotte M, Chabot GG.
  Title
Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.
  Journal
Mol Pharmacol 58:1341-8 (2000)
DOI:10.1124/mol.58.6.1341
Reference
PMID:17893666
  Authors
Nezzar H, Chiambaretta F, Marceau G, Blanchon L, Faye B, Dechelotte P, Rigal D, Sapin V.
  Title
Molecular and metabolic retinoid pathways in the human ocular surface.
  Journal
Mol Vis 13:1641-50 (2007)
Reference
PMID:16688755
  Authors
Blomhoff R, Blomhoff HK.
  Title
Overview of retinoid metabolism and function.
  Journal
J Neurobiol 66:606-30 (2006)
DOI:10.1002/neu.20242
Reference
PMID:16428379
  Authors
Liden M, Eriksson U.
  Title
Understanding retinol metabolism: structure and function of retinol dehydrogenases.
  Journal
J Biol Chem 281:13001-4 (2006)
DOI:10.1074/jbc.R500027200
Related
pathway
ko00906  Carotenoid biosynthesis

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