KEGG   DISEASE: ハンセン病
エントリ  
H00344                                                             
名称    
ハンセン病
概要    
Leprosy, also called Hansen's disease, is a chronic infection caused by Mycobacterium leprae (M. leprae) and the more recently discovered Mycobacterium lepromatosis (M. lepromatosis). It primarily affects peripheral nerves, skin and mucosa particularly the upper respiratory tract.
カテゴリ  
細菌感染症
階層分類  
ICD-11 による疾患分類 [BR:jp08403]
 01 感染症・寄生虫症
  マイコバクテリア症
   1B20  ハンセン病
    H00344  ハンセン病
パスウェイに基づく疾患分類 [BR:jp08402]
 免疫系
  nt06517  TLR シグナリング
   H00344  ハンセン病
ゲノムに基づく感染症分類 [BR:jp08401]
 細菌感染症
  放線菌による感染症
   H00344  ハンセン病
パスウェイ 
hsa04612  Antigen processing and presentation
hsa04650  Natural killer cell mediated cytotoxicity
hsa04620  Toll-like receptor signaling pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04141  Protein processing in endoplasmic reticulum
ネットワーク
nt06517 TLR signaling
病因遺伝子 
(LPRS3) TLR2 [HSA:7097] [KO:K10159]
(LPRS4) LTA [HSA:4049] [KO:K05468]
(LPRS5) TLR1 [HSA:7096] [KO:K05398]
病原体   
Mycobacterium leprae [GN:mle] (from India)
Mycobacterium leprae [GN:mlb] (from Brazil)
Mycobacterium lepromatosis [GN:mlm]
治療薬   
オフロキサシン [DR:D00453]
ジアフェニルスルホン [DR:D00592]
リファンピシン [DR:D00211]
クロファジミン [DR:D00278]
リンク   
ICD-11: 1B20
MeSH: D007918
OMIM: 609888 246300 610988 613223
MedlinePlus: 001347
文献    
  著者
Rodrigues LC, Lockwood DNj
  タイトル
Leprosy now: epidemiology, progress, challenges, and research gaps.
  雑誌
Lancet Infect Dis 11:464-70 (2011)
DOI:10.1016/S1473-3099(11)70006-8
文献    
  著者
Ploemacher T, Faber WR, Menke H, Rutten V, Pieters T
  タイトル
Reservoirs and transmission routes of leprosy; A systematic review.
  雑誌
PLoS Negl Trop Dis 14:e0008276 (2020)
DOI:10.1371/journal.pntd.0008276
文献    
PMID:15726416 (TLR2)
  著者
Malhotra D, Relhan V, Reddy BS, Bamezai R
  タイトル
TLR2 Arg677Trp polymorphism in leprosy: revisited.
  雑誌
Hum Genet 116:413-5 (2005)
DOI:10.1007/s00439-004-1249-9
文献    
PMID:17353895 (LTA)
  著者
Alcais A, Alter A, Antoni G, Orlova M, Nguyen VT, Singh M, Vanderborght PR, Katoch K, Mira MT, Vu HT, Ngyuen TH, Nguyen NB, Moraes M, Mehra N, Schurr E, Abel L
  タイトル
Stepwise replication identifies a low-producing lymphotoxin-alpha allele as a major risk factor for early-onset leprosy.
  雑誌
Nat Genet 39:517-22 (2007)
DOI:10.1038/ng2000
文献    
PMID:17548585 (TLR1)
  著者
Johnson CM, Lyle EA, Omueti KO, Stepensky VA, Yegin O, Alpsoy E, Hamann L, Schumann RR, Tapping RI
  タイトル
Cutting edge: A common polymorphism impairs cell surface trafficking and functional responses of TLR1 but protects against leprosy.
  雑誌
J Immunol 178:7520-4 (2007)
DOI:10.4049/jimmunol.178.12.7520
文献    
PMID:14737177 (PRKN)
  著者
Mira MT, Alcais A, Nguyen VT, Moraes MO, Di Flumeri C, Vu HT, Mai CP, Nguyen TH, Nguyen NB, Pham XK, Sarno EN, Alter A, Montpetit A, Moraes ME, Moraes JR, Dore C, Gallant CJ, Lepage P, Verner A, Van De Vosse E, Hudson TJ, Abel L, Schurr E
  タイトル
Susceptibility to leprosy is associated with PARK2 and PACRG.
  雑誌
Nature 427:636-40 (2004)
DOI:10.1038/nature02326
文献    
PMID:16728267 (HLA)
  著者
Geluk A, Ottenhoff TH
  タイトル
HLA and leprosy in the pre and postgenomic eras.
  雑誌
Hum Immunol 67:439-45 (2006)
DOI:10.1016/j.humimm.2006.03.009
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