KEGG   PATHWAY: eco02020
Entry
eco02020                    Pathway                                
Name
Two-component system - Escherichia coli K-12 MG1655
Description
Two-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor protein-histidine kinase (HK) and a response regulator (RR). In the prototypical two-component pathway, the sensor HK phosphorylates its own conserved His residue in response to a signal(s) in the environment. Subsequently, the phosphoryl group of HK is transferred onto a specific Asp residue on the RR. The activated RR can then effect changes in cellular physiology, often by regulating gene expression. Two-component pathways thus often enable cells to sense and respond to stimuli by inducing changes in transcription.
Class
Environmental Information Processing; Signal transduction
Pathway map
eco02020  Two-component system
eco02020

Other DBs
GO: 0000160
Organism
Escherichia coli K-12 MG1655 [GN:eco]
Gene
b0400  phoR; sensor histidine kinase PhoR [KO:K07636] [EC:2.7.13.3]
b0399  phoB; DNA-binding transcriptional dual regulator PhoB [KO:K07657]
b0383  phoA; alkaline phosphatase [KO:K01077] [EC:3.1.3.1]
b3728  pstS; phosphate ABC transporter periplasmic binding protein [KO:K02040]
b1129  phoQ; sensor histidine kinase PhoQ [KO:K07637] [EC:2.7.13.3]
b1130  phoP; DNA-binding transcriptional dual regulator PhoP [KO:K07660]
b3404  envZ; sensor histidine kinase EnvZ [KO:K07638] [EC:2.7.13.3]
b3405  ompR; DNA-binding transcriptional dual regulator OmpR [KO:K07659]
b2215  ompC; outer membrane porin C [KO:K09475]
b0929  ompF; outer membrane porin F [KO:K09476]
b3911  cpxA; sensor histidine kinase CpxA [KO:K07640] [EC:2.7.13.3]
b3912  cpxR; DNA-binding transcriptional dual regulator CpxR [KO:K07662]
b3096  mzrA; modulator protein MzrA [KO:K25864]
b1609  rstB; sensory histidine kinase RstB [KO:K07639] [EC:2.7.13.3]
b1608  rstA; DNA-binding transcriptional regulator RstA [KO:K07661]
b0161  degP; periplasmic serine endoprotease DegP [KO:K04771] [EC:3.4.21.107]
b4399  creC; sensory histidine kinase CreC [KO:K07641] [EC:2.7.13.3]
b4398  creB; DNA-binding transcriptional regulator CreB [KO:K07663]
b2078  baeS; sensor histidine kinase BaeS [KO:K07642] [EC:2.7.13.3]
b2079  baeR; DNA-binding transcriptional activator BaeR [KO:K07664]
b2074  mdtA; multidrug efflux pump membrane fusion protein MdtA [KO:K07799]
b2075  mdtB; multidrug efflux pump RND permease subunit MdtB [KO:K07788]
b2076  mdtC; multidrug efflux pump RND permease subunit MdtC [KO:K07789]
b2077  mdtD; putative multidrug efflux pump MdtD [KO:K18326]
b2470  acrD; multidrug efflux pump RND permease AcrD [KO:K18324]
b4112  basS; sensor histidine kinase BasS [KO:K07643] [EC:2.7.13.3]
b4113  basR; DNA-binding transcriptional dual regulator BasR [KO:K07771]
b2253  arnB; UDP-4-amino-4-deoxy-L-arabinose aminotransferase [KO:K07806] [EC:2.6.1.87]
b0570  cusS; sensor histidine kinase CusS [KO:K07644] [EC:2.7.13.3]
b0571  cusR; DNA-binding transcriptional activator CusR [KO:K07665]
b0572  cusC; copper/silver export system outer membrane channel [KO:K07796]
b0573  cusF; copper/silver export system periplasmic binding protein [KO:K07810]
b0574  cusB; copper/silver export system membrane fusion protein [KO:K07798]
b0575  cusA; copper/silver export system RND permease [KO:K07787]
b3026  qseC; sensor histidine kinase QseC [KO:K07645] [EC:2.7.13.3]
b3025  qseB; DNA-binding transcriptional activator QseB [KO:K07666]
b1892  flhD; DNA-binding transcriptional dual regulator FlhD [KO:K02403]
b1891  flhC; DNA-binding transcriptional dual regulator FlhC [KO:K02402]
b1923  fliC; flagellar filament structural protein [KO:K02406]
b1922  fliA; RNA polymerase, sigma 28 (sigma F) factor [KO:K02405]
b1890  motA; motility protein A [KO:K02556]
b0695  kdpD; sensor histidine kinase KdpD [KO:K07646] [EC:2.7.13.3]
b0694  kdpE; DNA-binding transcriptional activator KdpE [KO:K07667]
b0698  kdpA; K(+) transporting P-type ATPase subunit KdpA [KO:K01546]
b0697  kdpB; K(+) transporting P-type ATPase subunit KdpB [KO:K01547] [EC:7.2.2.6]
b0696  kdpC; K(+) transporting P-type ATPase subunit KdpC [KO:K01548]
b4513  kdpF; K(+) transporting P-type ATPase subunit KdpF [KO:K01545]
b0993  torS; sensory histidine kinase TorS [KO:K07647] [EC:2.7.13.3]
b0995  torR; DNA-binding transcriptional dual regulator TorR [KO:K07772]
b0996  torC; cytochrome c menaquinol dehydrogenase TorC [KO:K03532]
b0997  torA; trimethylamine N-oxide reductase 1 [KO:K07811] [EC:1.7.2.3]
b0998  torD; trimethylamine-N-oxide reductase-specific chaperone [KO:K03533]
b3210  arcB; sensor histidine kinase ArcB [KO:K07648] [EC:2.7.13.3]
b4401  arcA; DNA-binding transcriptional dual regulator ArcA [KO:K07773]
b3702  dnaA; chromosomal replication initiator protein DnaA [KO:K02313]
b1488  ddpX; D-alanyl-D-alanine dipeptidase [KO:K08641] [EC:3.4.13.22]
b0584  fepA; ferric enterobactin outer membrane transporter [KO:K19611]
b0619  dpiB; sensor histidine kinase DpiB [KO:K07700] [EC:2.7.13.3]
b0620  dpiA; DNA-binding transcriptional dual regulator DpiA [KO:K07702]
b0618  citC; citrate lyase synthetase [KO:K01910] [EC:6.2.1.22]
b0617  citD; citrate lyase acyl carrier protein [KO:K01646]
b0616  citE; citrate lyase beta subunit [KO:K01644] [EC:4.1.3.34]
b0615  citF; citrate lyase alpha subunit [KO:K01643] [EC:2.8.3.10]
b0614  citX; apo-citrate lyase phosphoribosyl-dephospho-CoA transferase [KO:K05964] [EC:2.7.7.61]
b0613  citG; triphosphoribosyl-dephospho-CoA synthase [KO:K05966] [EC:2.4.2.52]
b0612  citT; citrate:succinate antiporter [KO:K09477]
b0564  appY; DLP12 prophage; DNA-binding transcriptional activator AppY [KO:K07780]
b4125  dcuS; sensor histidine kinase DcuS [KO:K07701] [EC:2.7.13.3]
b4124  dcuR; DNA-binding transcriptional activator DcuR [KO:K07703]
b4123  dcuB; anaerobic C4-dicarboxylate transporter DcuB [KO:K07792]
b1479  maeA; NAD(+)-dependent malate dehydrogenase [KO:K00027] [EC:1.1.1.38]
b1222  narX; sensory histidine kinase NarX [KO:K07673] [EC:2.7.13.3]
b1221  narL; DNA-binding transcriptional dual regulator NarL [KO:K07684]
b2469  narQ; sensory histidine kinase NarQ [KO:K07674] [EC:2.7.13.3]
b2193  narP; DNA-binding transcriptional dual regulator NarP [KO:K07685]
b1224  narG; nitrate reductase A subunit alpha [KO:K00370] [EC:1.7.5.1 1.7.99.-]
b1468  narZ; nitrate reductase Z subunit alpha [KO:K00370] [EC:1.7.5.1 1.7.99.-]
b1225  narH; nitrate reductase A subunit beta [KO:K00371] [EC:1.7.5.1 1.7.99.-]
b1467  narY; nitrate reductase Z subunit beta [KO:K00371] [EC:1.7.5.1 1.7.99.-]
b1227  narI; nitrate reductase A subunit gamma [KO:K00374] [EC:1.7.5.1 1.7.99.-]
b1465  narV; nitrate reductase Z subunit gamma [KO:K00374] [EC:1.7.5.1 1.7.99.-]
b1226  narJ; nitrate reductase 1 molybdenum cofactor assembly chaperone [KO:K00373]
b1466  narW; NarW, putative private chaperone for NarZ nitrate reductase subunit [KO:K00373]
b1474  fdnG; formate dehydrogenase N subunit alpha [KO:K08348] [EC:1.17.5.3]
b1475  fdnH; formate dehydrogenase N subunit beta [KO:K08349]
b1476  fdnI; formate dehydrogenase N subunit gamma [KO:K08350]
b4154  frdA; fumarate reductase flavoprotein subunit [KO:K00244] [EC:1.3.5.1]
b4153  frdB; fumarate reductase iron-sulfur protein [KO:K00245] [EC:1.3.5.1]
b4152  frdC; fumarate reductase membrane protein FrdC [KO:K00246]
b4151  frdD; fumarate reductase membrane protein FrdD [KO:K00247]
b3667  uhpC; inner membrane protein sensing glucose-6-phosphate [KO:K07783]
b3668  uhpB; sensory histidine kinase UhpB [KO:K07675] [EC:2.7.13.3]
b3669  uhpA; DNA-binding transcriptional activator UhpA [KO:K07686]
b3666  uhpT; hexose-6-phosphate:phosphate antiporter [KO:K07784]
b0196  rcsF; sensor lipoprotein RcsF [KO:K06080]
b2218  rcsC; histidine kinase RcsC [KO:K07677] [EC:2.7.13.3]
b2216  rcsD; RcsD phosphotransferase [KO:K07676] [EC:2.7.13.3]
b1951  rcsA; DNA-binding transcriptional activator RcsA [KO:K07781]
b2217  rcsB; DNA-binding transcriptional activator RcsB [KO:K07687]
b2786  barA; sensor histidine kinase BarA [KO:K07678] [EC:2.7.13.3]
b1914  uvrY; DNA-binding transcriptional activator UvrY [KO:K07689]
b1916  sdiA; DNA-binding transcriptional dual regulator SdiA [KO:K07782]
b2696  csrA; carbon storage regulator [KO:K03563]
b2370  evgS; sensor histidine kinase EvgS [KO:K07679] [EC:2.7.13.3]
b2369  evgA; DNA-binding transcriptional activator EvgA [KO:K07690]
b2368  emrK; tripartite efflux pump membrane fusion protein EmrK [KO:K07797]
b2367  emrY; tripartite efflux pump membrane subunit EmrY [KO:K07786]
b1500  safA; two-component system connector SafA [KO:K23236]
b0535  fimZ; putative LuxR family transcriptional regulator FimZ [KO:K07688]
b4150  ampC; beta-lactamase [KO:K01467] [EC:3.5.2.6]
b4316  fimC; type 1 fimbriae periplasmic chaperone [KO:K07346]
b0939  elfD; putative fimbrial chaperone ElfD [KO:K07346]
b4317  fimD; type I fimbriae usher protein [KO:K07347]
b0940  elfC; putative fimbrial usher protein ElfC [KO:K07347]
b3144  yraJ; putative fimbrial usher protein YraJ [KO:K07347]
b0139  htrE; putative fimbrial usher protein HtrE [KO:K07347]
b2109  yehB; putative fimbrial usher protein YehB [KO:K07347]
b0167  glnD; PII uridylyltransferase/uridylyl removing enzyme [KO:K00990] [EC:2.7.7.59]
b2553  glnB; nitrogen regulatory protein PII-1 [KO:K04751]
b3869  glnL; sensory histidine kinase NtrB [KO:K07708] [EC:2.7.13.3]
b3868  glnG; DNA-binding transcriptional dual regulator NtrC [KO:K07712]
b3870  glnA; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
b4003  zraS; sensor histidine kinase ZraS [KO:K07709] [EC:2.7.13.3]
b4004  zraR; DNA-binding transcriptional activator ZraR [KO:K07713]
b4002  zraP; signaling pathway modulator ZraP [KO:K07803]
b2219  atoS; sensor histidine kinase AtoS [KO:K07710] [EC:2.7.13.3]
b2220  atoC; DNA-binding transcriptional activator/ornithine decarboxylase inhibitor AtoC [KO:K07714]
b2221  atoD; acetyl-CoA:acetoacetyl-CoA transferase subunit alpha [KO:K01034] [EC:2.8.3.8 2.8.3.9]
b2222  atoA; acetyl-CoA:acetoacetyl-CoA transferase subunit beta [KO:K01035] [EC:2.8.3.8 2.8.3.9]
b2223  atoE; short chain fatty acid transporter [KO:K02106]
b2224  atoB; acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
b2844  yqeF; putative acyltransferase [KO:K00626] [EC:2.3.1.9]
b3528  dctA; C4 dicarboxylate/orotate:H(+) symporter [KO:K11103]
b3202  rpoN; RNA polymerase, sigma 54 (sigma N) factor [KO:K03092]
b2556  glrK; histidine kinase GlrK [KO:K07711] [EC:2.7.13.3]
b2554  glrR; DNA-binding transcriptional activator GlrR [KO:K07715]
b4441  glmY; small regulatory RNA GlmY [KO:K15841]
b0972  hyaA; hydrogenase 1 small subunit [KO:K06282] [EC:1.12.99.6]
b2997  hybO; hydrogenase 2 small subunit [KO:K06282] [EC:1.12.99.6]
b2994  hybC; hydrogenase 2 large subunit [KO:K06281] [EC:1.12.99.6]
b0973  hyaB; hydrogenase 1 large subunit [KO:K06281] [EC:1.12.99.6]
b0974  hyaC; hydrogenase 1 cytochrome b subunit [KO:K03620]
b1884  cheR; chemotaxis protein methyltransferase [KO:K00575] [EC:2.1.1.80]
b4355  tsr; methyl-accepting chemotaxis protein Tsr [KO:K05874]
b1886  tar; methyl-accepting chemotaxis protein Tar [KO:K05875]
b1421  trg; methyl-accepting chemotaxis protein Trg [KO:K05876]
b1885  tap; methyl-accepting chemotaxis protein Tap [KO:K05877]
b3072  aer; aerotaxis sensor receptor, flavoprotein [KO:K03776]
b1887  cheW; chemotaxis protein CheW [KO:K03408]
b1888  cheA; chemotaxis protein CheA [KO:K03407] [EC:2.7.13.3]
b1882  cheY; chemotaxis protein CheY [KO:K03413]
b1883  cheB; protein-glutamate methylesterase/protein glutamine deamidase [KO:K03412] [EC:3.1.1.61 3.5.1.44]
b0652  gltL; glutamate/aspartate ABC transporter ATP binding subunit [KO:K10004] [EC:7.4.2.1]
b0653  gltK; glutamate/aspartate ABC transporter membrane subunit GltK [KO:K10002]
b0654  gltJ; glutamate/aspartate ABC transporter membrane subunit GltJ [KO:K10003]
b0655  gltI; glutamate/aspartate ABC transporter periplasmic binding protein [KO:K10001]
b3357  crp; DNA-binding transcriptional dual regulator CRP [KO:K10914]
b1524  glsB; glutaminase 2 [KO:K01425] [EC:3.5.1.2]
b0485  glsA; glutaminase 1 [KO:K01425] [EC:3.5.1.2]
b0733  cydA; cytochrome bd-I ubiquinol oxidase subunit I [KO:K00425] [EC:7.1.1.7]
b0978  appC; cytochrome bd-II ubiquinol oxidase subunit I [KO:K00425] [EC:7.1.1.7]
b0734  cydB; cytochrome bd-I ubiquinol oxidase subunit II [KO:K00426] [EC:7.1.1.7]
b0979  appB; cytochrome bd-II ubiquinol oxidase subunit II [KO:K00426] [EC:7.1.1.7]
b4515  cydX; cytochrome bd-I ubiquinol oxidase accessory subunit CydX [KO:K00424] [EC:7.1.1.7]
b4592  appX; small protein AppX [KO:K22501] [EC:7.1.1.7]
b3035  tolC; outer membrane channel TolC [KO:K12340]
b0983  gfcE; putative exopolysaccharide export lipoprotein GfcE [KO:K01991]
b2062  wza; outer membrane polysaccharide export protein Wza [KO:K01991]
b2061  wzb; protein-tyrosine phosphatase [KO:K25307] [EC:3.1.3.48]
b0982  etp; phosphotyrosine-protein phosphatase Etp [KO:K25307] [EC:3.1.3.48]
b2060  wzc; protein-tyrosine kinase Wzc [KO:K16692] [EC:2.7.10.3]
b0981  etk; protein-tyrosine kinase Etk [KO:K16692] [EC:2.7.10.3]
b3786  wecB; UDP-N-acetylglucosamine 2-epimerase [KO:K01791] [EC:5.1.3.14]
b3787  wecC; UDP-N-acetyl-D-mannosamine dehydrogenase [KO:K02472] [EC:1.1.1.336]
b0772  ybhC; outer membrane lipoprotein YhbC [KO:K01051] [EC:3.1.1.11]
b4293  fecI; RNA polymerase sigma factor FecI [KO:K23514]
b4292  fecR; ferric citrate regulator FecR [KO:K07165]
b1071  flgM; anti-sigma factor for FliA (sigma(28)) [KO:K02398]
Compound
C00007  Oxygen
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00034  Manganese
C00036  Oxaloacetate
C00038  Zinc cation
C00042  Succinate
C00049  L-Aspartate
C00064  L-Glutamine
C00070  Copper
C00088  Nitrite
C00092  D-Glucose 6-phosphate
C00122  Fumarate
C00149  (S)-Malate
C00158  Citrate
C00164  Acetoacetate
C00237  CO
C00238  Potassium cation
C00244  Nitrate
C00282  Hydrogen
C00291  Nickel
C00305  Magnesium cation
C00399  Ubiquinone
C00533  Nitric oxide
C00547  L-Noradrenaline
C00697  Nitrogen
C00788  L-Adrenaline
C00828  Menaquinone
C01019  L-Fucose
C01104  Trimethylamine N-oxide
C01667  Bacitracin
C02084  Tetrathionate
C05757  (3R)-3-Hydroxydodecanoyl-[acyl-carrier protein]
C05818  2-Demethylmenaquinone
C06230  Fe-enterobactin
C06689  Vancomycin
C06696  Lead
C11612  Polymyxin B
C11842  N-(3-(S)-Hydroxybutyryl)homoserine lactone
C11849  3-Hydroxy-palmitic acid methyl ester
C12008  Ramoplanin A2
C13768  Colistin sulfate
C14819  Fe3+
C16421  AI-2
C16463  3',5'-Cyclic diGMP
C16640  CAI-1
C16665  12-Methyltetradecanoic acid
C18206  cis-11-Methyl-2-dodecenoic acid
C21220  AIP-1
C21221  CSP
C21241  AIP-2
C21242  AIP-3
C21243  AIP-4
C21245  AgrD1 peptide
D07746  Colistin (INN)
D08401  Polymyxin B (INN)
Reference
PMID:15522865
  Authors
Yamamoto K, Hirao K, Oshima T, Aiba H, Utsumi R, Ishihama A.
  Title
Functional characterization in vitro of all two-component signal transduction systems from Escherichia coli.
  Journal
J Biol Chem 280:1448-56 (2005)
DOI:10.1074/jbc.M410104200
Reference
PMID:16030210
  Authors
Abdel-Fattah WR, Chen Y, Eldakak A, Hulett FM.
  Title
Bacillus subtilis phosphorylated PhoP: direct activation of the E(sigma)A- and repression of the E(sigma)E-responsive phoB-PS+V promoters during pho response.
  Journal
J Bacteriol 187:5166-78 (2005)
DOI:10.1128/JB.187.15.5166-5178.2005
Reference
PMID:15813739
  Authors
Navarre WW, Halsey TA, Walthers D, Frye J, McClelland M, Potter JL, Kenney LJ, Gunn JS, Fang FC, Libby SJ.
  Title
Co-regulation of Salmonella enterica genes required for virulence and resistance to antimicrobial peptides by SlyA and PhoP/PhoQ.
  Journal
Mol Microbiol 56:492-508 (2005)
DOI:10.1111/j.1365-2958.2005.04553.x
Reference
PMID:11973328
  Authors
Cai SJ, Inouye M.
  Title
EnvZ-OmpR interaction and osmoregulation in Escherichia coli.
  Journal
J Biol Chem 277:24155-61 (2002)
DOI:10.1074/jbc.M110715200
Reference
PMID:16077119
  Authors
Batchelor E, Walthers D, Kenney LJ, Goulian M.
  Title
The Escherichia coli CpxA-CpxR envelope stress response system regulates expression of the porins ompF and ompC.
  Journal
J Bacteriol 187:5723-31 (2005)
DOI:10.1128/JB.187.16.5723-5731.2005
Reference
PMID:12107133
  Authors
Nagakubo S, Nishino K, Hirata T, Yamaguchi A.
  Title
The putative response regulator BaeR stimulates multidrug resistance of Escherichia coli via a novel multidrug exporter system, MdtABC.
  Journal
J Bacteriol 184:4161-7 (2002)
DOI:10.1128/JB.184.15.4161-4167.2002
Reference
PMID:15322361
  Authors
Hagiwara D, Yamashino T, Mizuno T.
  Title
A Genome-wide view of the Escherichia coli BasS-BasR two-component system implicated in iron-responses.
  Journal
Biosci Biotechnol Biochem 68:1758-67 (2004)
DOI:10.1271/bbb.68.1758
Reference
PMID:11004187
  Authors
Munson GP, Lam DL, Outten FW, O'Halloran TV.
  Title
Identification of a copper-responsive two-component system on the chromosome of Escherichia coli K-12.
  Journal
J Bacteriol 182:5864-71 (2000)
DOI:10.1128/JB.182.20.5864-5871.2000
Reference
PMID:11929534
  Authors
Sperandio V, Torres AG, Kaper JB.
  Title
Quorum sensing Escherichia coli regulators B and C (QseBC): a novel two-component regulatory system involved in the regulation of flagella and motility by quorum sensing in E. coli.
  Journal
Mol Microbiol 43:809-21 (2002)
DOI:10.1046/j.1365-2958.2002.02803.x
Reference
PMID:14604015
  Authors
Epstein W.
  Title
The roles and regulation of potassium in bacteria.
  Journal
Prog Nucleic Acid Res Mol Biol 75:293-320 (2003)
DOI:10.1016/S0079-6603(03)75008-9
Reference
PMID:10648521
  Authors
Ansaldi M, Simon G, Lepelletier M, Mejean V.
  Title
The TorR high-affinity binding site plays a key role in both torR autoregulation and torCAD operon expression in Escherichia coli.
  Journal
J Bacteriol 182:961-6 (2000)
DOI:10.1128/JB.182.4.961-966.2000
Reference
PMID:15326287
  Authors
Malpica R, Franco B, Rodriguez C, Kwon O, Georgellis D.
  Title
Identification of a quinone-sensitive redox switch in the ArcB sensor kinase.
  Journal
Proc Natl Acad Sci U S A 101:13318-23 (2004)
DOI:10.1073/pnas.0403064101
Reference
PMID:2666399
  Authors
Widenhorn KA, Somers JM, Kay WW.
  Title
Genetic regulation of the tricarboxylate transport operon (tctI) of Salmonella typhimurium.
  Journal
J Bacteriol 171:4436-41 (1989)
DOI:10.1128/JB.171.8.4436-4441.1989
Reference
PMID:11555295
  Authors
Hyyrylainen HL, Bolhuis A, Darmon E, Muukkonen L, Koski P, Vitikainen M, Sarvas M, Pragai Z, Bron S, van Dijl JM, Kontinen VP.
  Title
A novel two-component regulatory system in Bacillus subtilis for the survival of severe secretion stress.
  Journal
Mol Microbiol 41:1159-72 (2001)
DOI:10.1046/j.1365-2958.2001.02576.x
Reference
PMID:10972837
  Authors
Zhang X, Hulett FM.
  Title
ResD signal transduction regulator of aerobic respiration in Bacillus subtilis: ctaA promoter regulation.
  Journal
Mol Microbiol 37:1208-19 (2000)
DOI:10.1046/j.1365-2958.2000.02076.x
Reference
PMID:15937169
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Related
pathway
eco00190  Oxidative phosphorylation
eco00550  Peptidoglycan biosynthesis
eco00910  Nitrogen metabolism
eco02030  Bacterial chemotaxis
eco02040  Flagellar assembly
eco03070  Bacterial secretion system
KO pathway
ko02020   
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