KEGG   PATHWAY: ect00290
Entry
ect00290                    Pathway                                
Name
Valine, leucine and isoleucine biosynthesis - Escherichia coli O7:K1 IAI39 (ExPEC)
Class
Metabolism; Amino acid metabolism
Pathway map
ect00290  Valine, leucine and isoleucine biosynthesis
ect00290

Module
ect_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:ect00290]
ect_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:ect00290]
ect_M00570  Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:ect00290]
Other DBs
GO: 0009097 0009098 0009099
Organism
Escherichia coli O7:K1 IAI39 (ExPEC) [GN:ect]
Gene
ECIAI39_0076  leuD; 3-isopropylmalate isomerase subunit [KO:K01704] [EC:4.2.1.33 4.2.1.35]
ECIAI39_0077  leuC; 3-isopropylmalate isomerase subunit, dehydratase component [KO:K01703] [EC:4.2.1.33 4.2.1.35]
ECIAI39_0078  leuB; 3-isopropylmalate dehydrogenase [KO:K00052] [EC:1.1.1.85]
ECIAI39_0079  leuA; 2-isopropylmalate synthase [KO:K01649] [EC:2.3.3.13]
ECIAI39_0081  ilvI; acetolactate synthase III, large subunit [KO:K01652] [EC:2.2.1.6]
ECIAI39_0082  ilvH; acetolactate synthase III, thiamin-dependent, small subunit [KO:K01653] [EC:2.2.1.6]
ECIAI39_2437  yfbQ; putative aminotransferase [KO:K14260] [EC:2.6.1.66 2.6.1.2]
ECIAI39_3012  ilvC; ketol-acid reductoisomerase, NAD(P)-binding [KO:K00053] [EC:1.1.1.86]
ECIAI39_3014  ilvA; threonine deaminase [KO:K01754] [EC:4.3.1.19]
ECIAI39_3015  ilvD; dihydroxyacid dehydratase [KO:K01687] [EC:4.2.1.9]
ECIAI39_3016  ilvE; branched-chain amino-acid aminotransferase [KO:K00826] [EC:2.6.1.42]
ECIAI39_3017  ilvM; acetolactate synthase II, small subunit [KO:K11258] [EC:2.2.1.6]
ECIAI39_3018  ilvG; Acetolactate synthase isozyme II large subunit (ALS-II) (Acetohydroxy-acid synthase II large subunit) (AHAS-II) [KO:K01652] [EC:2.2.1.6]
ECIAI39_3618  tdcB; catabolic threonine dehydratase, PLP-dependent [KO:K01754] [EC:4.3.1.19]
ECIAI39_4084  avtA; valine-pyruvate aminotransferase [KO:K00835] [EC:2.6.1.66]
ECIAI39_4272  ilvN; acetolactate synthase I, small subunit [KO:K01653] [EC:2.2.1.6]
ECIAI39_4273  ilvB; acetolactate synthase I, large subunit [KO:K01652] [EC:2.2.1.6]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00109  2-Oxobutanoate
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00183  L-Valine
C00188  L-Threonine
C00233  4-Methyl-2-oxopentanoate
C00407  L-Isoleucine
C00671  (S)-3-Methyl-2-oxopentanoic acid
C02226  2-Methylmaleate
C02504  alpha-Isopropylmalate
C02612  (R)-2-Methylmalate
C02631  2-Isopropylmaleate
C04181  3-Hydroxy-3-methyl-2-oxobutanoic acid
C04236  (2S)-2-Isopropyl-3-oxosuccinate
C04272  (R)-2,3-Dihydroxy-3-methylbutanoate
C04411  (2R,3S)-3-Isopropylmalate
C06006  (S)-2-Aceto-2-hydroxybutanoate
C06007  (R)-2,3-Dihydroxy-3-methylpentanoate
C06010  (S)-2-Acetolactate
C06032  D-erythro-3-Methylmalate
C14463  (R)-3-Hydroxy-3-methyl-2-oxopentanoate
Reference
  Authors
Xu H, Zhang Y, Guo X, Ren S, Staempfli AA, Chiao J, Jiang W, Zhao G.
  Title
Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway.
  Journal
J Bacteriol 186:5400-9 (2004)
DOI:10.1128/JB.186.16.5400-5409.2004
Related
pathway
ect00260  Glycine, serine and threonine metabolism
ect00280  Valine, leucine and isoleucine degradation
ect00620  Pyruvate metabolism
KO pathway
ko00290   

DBGET integrated database retrieval system