KEGG PATHWAY: esl00984

PATHWAY: esl00984

Entry

esl00984                    Pathway

Name

Steroid degradation - Escherichia coli O104:H4 2011C-3493 (EAEC)

Class

Metabolism; Xenobiotics biodegradation and metabolism

Pathway map

esl00984

Steroid degradation

Other DBs

GO:

0006707

Organism

Escherichia coli O104:H4 2011C-3493 (EAEC) [GN:esl]

Gene

O3K_07785

fadI; 3-ketoacyl-CoA thiolase [KO:K00632] [EC:2.3.1.16]

O3K_24640

fadA; 3-ketoacyl-CoA thiolase [KO:K00632] [EC:2.3.1.16]

Compound

C00022

Pyruvate

C00024

Acetyl-CoA

C00091

Succinyl-CoA

C00100

Propanoyl-CoA

C00187

Cholesterol

C00280

Androstenedione

C00479

Propanal

C00535

Testosterone

C00599

Cholest-4-en-3-one

C00674

5alpha-Androstane-3,17-dione

C01227

Dehydroepiandrosterone

C04793

3,4-Dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione

C04844

3-Hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate

C06762

4-Hydroxy-2-oxohexanoic acid

C07635

Epiandrosterone

C11354

2-Hydroxy-cis-hex-2,4-dienoate

C14909

9alpha-Hydroxyandrosta-1,4-diene-3,17-dione

C19944

3-Hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione

C20144

Androsta-1,4-diene-3,17-dione

C20199

3-[(3aS,4S,7aS)-7a-Methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate

C20252

5-Androstene-3,17-dione

C20838

3-[(3aS,4S,7aS)-7a-Methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA

C20839

(25R)-3-Oxocholest-4-en-26-oate

C20840

(25S)-3-Oxocholest-4-en-26-oyl-CoA

C21076

Delta4-Dafachronic acid

C21906

3-Oxochol-4-en-24-oyl-CoA

C23003

3-[(3aS,4S,5R,7aS)-5-Hydroxy-7a-methyl-1-oxooctahydro-1H-inden-4-yl]propanoyl-CoA

C23004

(2E)-3-[(3aS,4S,5R,7aS)-5-Hydroxy-7a-methyl-1-oxooctahydro-1H-inden-4-yl]prop-2-enoyl-CoA

C23005

3-[(3aS,4S,5R,7aS)-5-Hydroxy-7a-methyl-1-oxooctahydro-1H-inden-4-yl]-3-hydroxypropanoyl-CoA

C23006

3-[(3aS,4S,5R,7aS)-5-Hydroxy-7a-methyl-1-oxooctahydro-1H-inden-4-yl]-3-oxopropanoyl-CoA

C23007

(3aS,4S,5R,7aS)-5-Hydroxy-7a-methyl-1-oxooctahydro-1H-indene-4-carboxyl-CoA

C23009

(7aS)-7a-Methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-4-carboxyl-CoA

C23010

3-Oxocholest-4,24-dien-26-oyl-CoA

C23011

(25R)-3-Oxocholest-4-en-26-oyl-CoA

C23012

24-Hydroxy-3-oxocholest-4-en-26-oyl-CoA

C23013

3,24-Dioxocholest-4-en-26-oyl-CoA

C23014

3-Oxochol-4,22-dien-24-oyl-CoA

C23015

(22S)-Hydroxy-3-oxochol-4-en-24-oyl-CoA

C23016

3,22-Dioxochol-4-en-24-oyl-CoA

C23017

3-Oxopregnene-20-carboxyl-CoA

C23018

3-Oxo-4,17-pregnadiene-20-carboxyl-CoA

C23019

17-Hydroxy-3-oxo-4-pregnene-20-carboxyl-CoA

C23020

(3R)-2-(2-carboxyethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA

C23021

9-Carboxy-6-methyl-3,7-dioxononanoyl-CoA

C23022

7-Carboxy-4-methyl-5-oxoheptanoyl-CoA

C23023

(2E)-7-Carboxy-4-methyl-5-oxohept-2-enoyl-CoA

C23024

7-Carboxy-3-hydroxy-4-methyl-5-oxoheptanoyl-CoA

C23025

7-Carboxy-4-methyl-3,5-dioxoheptanoyl-CoA

C23026

5-Carboxy-2-methyl-3-oxopentanoyl-CoA

Reference

PMID:31284586

Authors

Olivera ER, Luengo JM.

Title

Steroids as Environmental Compounds Recalcitrant to Degradation: Genetic Mechanisms of Bacterial Biodegradation Pathways.

Journal

Genes (Basel) 10 (2019)
DOI:10.3390/genes10070512

Reference

PMID:21056662

Authors

Horinouchi M, Hayashi T, Kudo T

Title

Steroid degradation in Comamonas testosteroni.

Journal

J Steroid Biochem Mol Biol 129:4-14 (2012)
DOI:10.1016/j.jsbmb.2010.10.008

Reference

PMID:20554032

Authors

Horinouchi M, Kurita T, Hayashi T, Kudo T

Title

Steroid degradation genes in Comamonas testosteroni TA441: Isolation of genes encoding a Delta4(5)-isomerase and 3alpha- and 3beta-dehydrogenases and evidence for a 100 kb steroid degradation gene hot spot.

Journal

J Steroid Biochem Mol Biol 122:253-63 (2010)
DOI:10.1016/j.jsbmb.2010.06.002

Reference

PMID:34232729

Authors

Horinouchi M, Hayashi T.

Title

Identification of the Coenzyme A (CoA) Ester Intermediates and Genes Involved in the Cleavage and Degradation of the Steroidal C-Ring by Comamonas testosteroni TA441.

Journal

Appl Environ Microbiol 87:e0110221 (2021)
DOI:10.1128/AEM.01102-21

Reference

PMID:37815361

Authors

Horinouchi M, Hayashi T.

Title

Comprehensive summary of steroid metabolism in Comamonas testosteroni TA441: entire degradation process of basic four rings and removal of C12 hydroxyl group.

Journal

Appl Environ Microbiol 89:e0014323 (2023)
DOI:10.1128/aem.00143-23

Reference

PMID:21924910

Authors

Ouellet H, Johnston JB, de Montellano PR

Title

Cholesterol catabolism as a therapeutic target in Mycobacterium tuberculosis.

Journal

Trends Microbiol 19:530-9 (2011)
DOI:10.1016/j.tim.2011.07.009

Reference

PMID:17264217

Authors

Van der Geize R, Yam K, Heuser T, Wilbrink MH, Hara H, Anderton MC, Sim E, Dijkhuizen L, Davies JE, Mohn WW, Eltis LD

Title

A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages.

Journal

Proc Natl Acad Sci U S A 104:1947-52 (2007)
DOI:10.1073/pnas.0605728104

Reference

PMID:22045806

Authors

Thomas ST, VanderVen BC, Sherman DR, Russell DG, Sampson NS

Title

Pathway profiling in Mycobacterium tuberculosis: elucidation of cholesterol-derived catabolite and enzymes that catalyze its metabolism.

Journal

J Biol Chem 286:43668-78 (2011)
DOI:10.1074/jbc.M111.313643

Reference

PMID:28377529

Authors

Crowe AM, Casabon I, Brown KL, Liu J, Lian J, Rogalski JC, Hurst TE, Snieckus V, Foster LJ, Eltis LD.

Title

Catabolism of the Last Two Steroid Rings in Mycobacterium tuberculosis and Other Bacteria.

Journal

mBio 8 (2017)
DOI:10.1128/mBio.00321-17

Reference

PMID:33826843

Authors

Yuan T, Werman JM, Yin X, Yang M, Garcia-Diaz M, Sampson NS.

Title

Enzymatic beta-Oxidation of the Cholesterol Side Chain in Mycobacterium tuberculosis Bifurcates Stereospecifically at Hydration of 3-Oxo-cholest-4,22-dien-24-oyl-CoA.

Journal

ACS Infect Dis 7:1739-1751 (2021)
DOI:10.1021/acsinfecdis.1c00069

Related
pathway

esl00010

Glycolysis / Gluconeogenesis

esl00020

Citrate cycle (TCA cycle)

esl00640

Propanoate metabolism

KO pathway

ko00984

DBGET integrated database retrieval system