PATHWAY: ko00984 Help
Entry Name Steroid degradation
Class Metabolism; Xenobiotics biodegradation and metabolismBRITE hierarchy
Pathway map Other DBs Orthology K05296 E1.1.1.51; 3(or 17)beta-hydroxysteroid dehydrogenase [EC:1.1.1.51 ]
K16047 hsaA; 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase [EC:1.14.14.12 ]
K16048 hsaB; 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase reductase component [EC:1.5.1.-]
K16049 hsaC; 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase [EC:1.13.11.25 ]
K16050 hsaD; 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase [EC:3.7.1.17 ]
K18365 bphI, xylK, nahM, tesG; 4-hydroxy-2-oxovalerate/4-hydroxy-2-oxohexanoate aldolase [EC:4.1.3.39 4.1.3.43 ]
K22818 fadE26; 3-oxocholest-4-en-26-oyl-CoA dehydrogenase alpha subunit [EC:1.3.99.-]
K22819 fadE27; 3-oxocholest-4-en-26-oyl-CoA dehydrogenase beta subunit [EC:1.3.99.-]
K22820 fadE34; 3-oxochol-4-en-24-oyl-CoA dehydrogenase [EC:1.3.99.-]
K22821 fadE28; 3-oxo-4-pregnene-20-carboxyl-CoA dehydrogenase alpha subunit [EC:1.3.99.-]
K22822 fadE29; 3-oxo-4-pregnene-20-carboxyl-CoA dehydrogenase beta subunit [EC:1.3.99.-]
K25621 chsH2; 3-oxo-4,17-pregnadiene-20-carboxyl-CoA hydratase alpha subunit
K25622 chsH1; 3-oxo-4,17-pregnadiene-20-carboxyl-CoA hydratase beta subunit
K25623 ltp2; 17-hydroxy-3-oxo-4-pregnene-20-carboxyl-CoA lyase
K28218 chsH3; 3-oxochol-4,22-dien-24-oyl-CoA hydratase (S-form)
K28219 chsB1, hsd4A; (22S)-hydroxy-3-oxochol-4-en-24-oyl-CoA dehydrogenase
K28220 scdG, IpdF; hydroxylacyl dehydrogenase
K28221 scdC1, fadE33, ipdE2; 5OH-HIP-CoA dehydrogenase
K28222 scdC2, fadE30, ipdE1; 5OH-HIP-CoA dehydrogenase
K28224 scdD; enoyl-CoA hydratase
K28225 scdE; 3-hydroxyl acyl-CoA dehydrogenase
K28226 scdK, ipdC; acyl-CoA dehydrogenase
K28227 scdY, echA20; HIEC-CoA hydrolase
K28228 scdL1, ipdA; COCHEA-CoA hydrolase alpha subunit
K28229 scdL2, ipdB; COCHEA-CoA hydrolase beta subunit
K28230 scdM1, fadE31; acyl-CoA dehydrogenase
K28231 scdM2, fadE32; acyl-CoA dehydrogenase
K28232 scdN; enoyl-CoA hydratase
Compound C00674 5alpha-Androstane-3,17-dione
C04793 3,4-Dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione
C04844 3-Hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate
C06762 4-Hydroxy-2-oxohexanoic acid
C11354 2-Hydroxy-cis-hex-2,4-dienoate
C14909 9alpha-Hydroxyandrosta-1,4-diene-3,17-dione
C19944 3-Hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione
C20144 Androsta-1,4-diene-3,17-dione
C20199 3-[(3aS,4S,7aS)-7a-Methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate
C20252 5-Androstene-3,17-dione
C20838 3-[(3aS,4S,7aS)-7a-Methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA
C20839 (25R)-3-Oxocholest-4-en-26-oate
C20840 (25S)-3-Oxocholest-4-en-26-oyl-CoA
C21076 Delta4-Dafachronic acid
C21906 3-Oxochol-4-en-24-oyl-CoA
C23003 3-[(3aS,4S,5R,7aS)-5-Hydroxy-7a-methyl-1-oxooctahydro-1H-inden-4-yl]propanoyl-CoA
C23004 (2E)-3-[(3aS,4S,5R,7aS)-5-Hydroxy-7a-methyl-1-oxooctahydro-1H-inden-4-yl]prop-2-enoyl-CoA
C23005 3-[(3aS,4S,5R,7aS)-5-Hydroxy-7a-methyl-1-oxooctahydro-1H-inden-4-yl]-3-hydroxypropanoyl-CoA
C23006 3-[(3aS,4S,5R,7aS)-5-Hydroxy-7a-methyl-1-oxooctahydro-1H-inden-4-yl]-3-oxopropanoyl-CoA
C23007 (3aS,4S,5R,7aS)-5-Hydroxy-7a-methyl-1-oxooctahydro-1H-indene-4-carboxyl-CoA
C23009 (7aS)-7a-Methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-4-carboxyl-CoA
C23010 3-Oxocholest-4,24-dien-26-oyl-CoA
C23011 (25R)-3-Oxocholest-4-en-26-oyl-CoA
C23012 24-Hydroxy-3-oxocholest-4-en-26-oyl-CoA
C23013 3,24-Dioxocholest-4-en-26-oyl-CoA
C23014 3-Oxochol-4,22-dien-24-oyl-CoA
C23015 (22S)-Hydroxy-3-oxochol-4-en-24-oyl-CoA
C23016 3,22-Dioxochol-4-en-24-oyl-CoA
C23017 3-Oxopregnene-20-carboxyl-CoA
C23018 3-Oxo-4,17-pregnadiene-20-carboxyl-CoA
C23019 17-Hydroxy-3-oxo-4-pregnene-20-carboxyl-CoA
C23020 (3R)-2-(2-carboxyethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA
C23021 9-Carboxy-6-methyl-3,7-dioxononanoyl-CoA
C23022 7-Carboxy-4-methyl-5-oxoheptanoyl-CoA
C23023 (2E)-7-Carboxy-4-methyl-5-oxohept-2-enoyl-CoA
C23024 7-Carboxy-3-hydroxy-4-methyl-5-oxoheptanoyl-CoA
C23025 7-Carboxy-4-methyl-3,5-dioxoheptanoyl-CoA
C23026 5-Carboxy-2-methyl-3-oxopentanoyl-CoA
Reference Authors Olivera ER, Luengo JM.
Title Steroids as Environmental Compounds Recalcitrant to Degradation: Genetic Mechanisms of Bacterial Biodegradation Pathways.
Journal Reference Authors Horinouchi M, Hayashi T, Kudo T
Title Steroid degradation in Comamonas testosteroni.
Journal Reference Authors Horinouchi M, Kurita T, Hayashi T, Kudo T
Title Steroid degradation genes in Comamonas testosteroni TA441: Isolation of genes encoding a Delta4(5)-isomerase and 3alpha- and 3beta-dehydrogenases and evidence for a 100 kb steroid degradation gene hot spot.
Journal Reference Authors Horinouchi M, Hayashi T.
Title Identification of the Coenzyme A (CoA) Ester Intermediates and Genes Involved in the Cleavage and Degradation of the Steroidal C-Ring by Comamonas testosteroni TA441.
Journal Reference Authors Horinouchi M, Hayashi T.
Title Comprehensive summary of steroid metabolism in Comamonas testosteroni TA441: entire degradation process of basic four rings and removal of C12 hydroxyl group.
Journal Reference Authors Ouellet H, Johnston JB, de Montellano PR
Title Cholesterol catabolism as a therapeutic target in Mycobacterium tuberculosis.
Journal Reference Authors Van der Geize R, Yam K, Heuser T, Wilbrink MH, Hara H, Anderton MC, Sim E, Dijkhuizen L, Davies JE, Mohn WW, Eltis LD
Title A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages.
Journal Reference Authors Thomas ST, VanderVen BC, Sherman DR, Russell DG, Sampson NS
Title Pathway profiling in Mycobacterium tuberculosis: elucidation of cholesterol-derived catabolite and enzymes that catalyze its metabolism.
Journal Reference Authors Crowe AM, Casabon I, Brown KL, Liu J, Lian J, Rogalski JC, Hurst TE, Snieckus V, Foster LJ, Eltis LD.
Title Catabolism of the Last Two Steroid Rings in Mycobacterium tuberculosis and Other Bacteria.
Journal Reference Authors Yuan T, Werman JM, Yin X, Yang M, Garcia-Diaz M, Sampson NS.
Title Enzymatic beta-Oxidation of the Cholesterol Side Chain in Mycobacterium tuberculosis Bifurcates Stereospecifically at Hydration of 3-Oxo-cholest-4,22-dien-24-oyl-CoA.
Journal Related ko00010 Glycolysis / Gluconeogenesis
ko00140 Steroid hormone biosynthesis
