KEGG   NETWORK: N01446
Entry
N01446                      Network                                
Name
DNA end resection and RPA loading
Definition
MRN == CtIP == BRCA1+BARD1 == UIMC1+ABRAXAS+BABAM1+BRE+BRCC3 -> BLM,WRN+DNA2+MRN == RPA
  Expanded
4361+10111+4683 == 5932 == 672+580 == 51720+84142+29086+9577+79184 -> 641,7486+1763+4361+10111+4683 == (6117+6118+6119+29935)
Class
nt06506 Double-strand break repair
Type
Reference
Pathway
hsa03440  Homologous recombination
Gene
4361  MRE11; MRE11 homolog, double strand break repair nuclease
10111  RAD50; RAD50 double strand break repair protein
4683  NBN; nibrin
5932  RBBP8; RB binding protein 8, endonuclease
672  BRCA1; BRCA1 DNA repair associated
580  BARD1; BRCA1 associated RING domain 1
51720  UIMC1; ubiquitin interaction motif containing 1
84142  ABRAXAS1; abraxas 1, BRCA1 A complex subunit
29086  BABAM1; BRISC and BRCA1 A complex member 1
9577  BABAM2; BRISC and BRCA1 A complex member 2
79184  BRCC3; BRCA1/BRCA2-containing complex subunit 3
641  BLM; BLM RecQ like helicase
7486  WRN; WRN RecQ like helicase
1763  DNA2; DNA replication helicase/nuclease 2
6117  RPA1; replication protein A1
6118  RPA2; replication protein A2
6119  RPA3; replication protein A3
29935  RPA4; replication protein A4
Reference
PMID:32971475
  Authors
Rahimian E, Amini A, Alikarami F, Pezeshki SMS, Saki N, Safa M
  Title
DNA repair pathways as guardians of the genome: Therapeutic potential and possible prognostic role in hematologic neoplasms.
  Journal
DNA Repair (Amst) 96:102951 (2020)
DOI:10.1016/j.dnarep.2020.102951
Reference
PMID:31711518
  Authors
Mota MBS, Carvalho MA, Monteiro ANA, Mesquita RD
  Title
DNA damage response and repair in perspective: Aedes aegypti, Drosophila melanogaster and Homo sapiens.
  Journal
Parasit Vectors 12:533 (2019)
DOI:10.1186/s13071-019-3792-1
Reference
PMID:31748913
  Authors
Sun Y, McCorvie TJ, Yates LA, Zhang X
  Title
Structural basis of homologous recombination.
  Journal
Cell Mol Life Sci 77:3-18 (2020)
DOI:10.1007/s00018-019-03365-1
Reference
PMID:30551670
  Authors
Sullivan MR, Bernstein KA
  Title
RAD-ical New Insights into RAD51 Regulation.
  Journal
Genes (Basel) 9:629 (2018)
DOI:10.3390/genes9120629
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