KEGG   Homo sapiens (human): 103
Entry
103               CDS       T01001                                 
Symbol
ADAR, ADAR1, AGS6, DRADA, DSH, DSRAD, G1P1, IFI-4, IFI4, K88DSRBP, P136
Name
(RefSeq) double-stranded RNA-specific adenosine deaminase isoform a
  KO
K12968  double-stranded RNA-specific adenosine deaminase [EC:3.5.4.37]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04622  RIG-I-like receptor signaling pathway
hsa04623  Cytosolic DNA-sensing pathway
hsa05162  Measles
hsa05164  Influenza A
hsa05171  Coronavirus disease
Network
nt06519  RLR signaling
  Element
N01565  Adenosine-to-inosine RNA editing by ADAR
Disease
H00290  Aicardi-Goutieres syndrome
H00880  Dyschromatosis symmetrica hereditaria
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04622 RIG-I-like receptor signaling pathway
    103 (ADAR)
   04623 Cytosolic DNA-sensing pathway
    103 (ADAR)
 09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease
    103 (ADAR)
   05164 Influenza A
    103 (ADAR)
   05162 Measles
    103 (ADAR)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03041 Spliceosome [BR:hsa03041]
    103 (ADAR)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.4  In cyclic amidines
    3.5.4.37  double-stranded RNA adenine deaminase
     103 (ADAR)
Spliceosome [BR:hsa03041]
 Other splicing related proteins
  Spliceosome associated proteins (SAPs)
   RNA binding proteins (RBPs)
    103 (ADAR)
SSDB
Motif
Pfam: A_deamin z-alpha dsrm TrmB PF0610-like_N
Other DBs
NCBI-GeneID: 103
NCBI-ProteinID: NP_001102
OMIM: 146920
HGNC: 225
Ensembl: ENSP00000357459.4
UniProt: P55265
Structure
LinkDB
Position
1:complement(154582057..154627997)
AA seq 1226 aa
MNPRQGYSLSGYYTHPFQGYEHRQLRYQQPGPGSSPSSFLLKQIEFLKGQLPEAPVIGKQ
TPSLPPSLPGLRPRFPVLLASSTRGRQVDIRGVPRGVHLRSQGLQRGFQHPSPRGRSLPQ
RGVDCLSSHFQELSIYQDQEQRILKFLEELGEGKATTAHDLSGKLGTPKKEINRVLYSLA
KKGKLQKEAGTPPLWKIAVSTQAWNQHSGVVRPDGHSQGAPNSDPSLEPEDRNSTSVSED
LLEPFIAVSAQAWNQHSGVVRPDSHSQGSPNSDPGLEPEDSNSTSALEDPLEFLDMAEIK
EKICDYLFNVSDSSALNLAKNIGLTKARDINAVLIDMERQGDVYRQGTTPPIWHLTDKKR
ERMQIKRNTNSVPETAPAAIPETKRNAEFLTCNIPTSNASNNMVTTEKVENGQEPVIKLE
NRQEARPEPARLKPPVHYNGPSKAGYVDFENGQWATDDIPDDLNSIRAAPGEFRAIMEMP
SFYSHGLPRCSPYKKLTECQLKNPISGLLEYAQFASQTCEFNMIEQSGPPHEPRFKFQVV
INGREFPPAEAGSKKVAKQDAAMKAMTILLEEAKAKDSGKSEESSHYSTEKESEKTAESQ
TPTPSATSFFSGKSPVTTLLECMHKLGNSCEFRLLSKEGPAHEPKFQYCVAVGAQTFPSV
SAPSKKVAKQMAAEEAMKALHGEATNSMASDNQPEGMISESLDNLESMMPNKVRKIGELV
RYLNTNPVGGLLEYARSHGFAAEFKLVDQSGPPHEPKFVYQAKVGGRWFPAVCAHSKKQG
KQEAADAALRVLIGENEKAERMGFTEVTPVTGASLRRTMLLLSRSPEAQPKTLPLTGSTF
HDQIAMLSHRCFNTLTNSFQPSLLGRKILAAIIMKKDSEDMGVVVSLGTGNRCVKGDSLS
LKGETVNDCHAEIISRRGFIRFLYSELMKYNSQTAKDSIFEPAKGGEKLQIKKTVSFHLY
ISTAPCGDGALFDKSCSDRAMESTESRHYPVFENPKQGKLRTKVENGEGTIPVESSDIVP
TWDGIRLGERLRTMSCSDKILRWNVLGLQGALLTHFLQPIYLKSVTLGYLFSQGHLTRAI
CCRVTRDGSAFEDGLRHPFIVNHPKVGRVSIYDSKRQSGKTKETSVNWCLADGYDLEILD
GTRGTVDGPRNELSRVSKKNIFLLFKKLCSFRYRRDLLRLSYGEAKKAARDYETAKNYFK
KGLKDMGYGNWISKPQEEKNFYLCPV
NT seq 3681 nt   +upstreamnt  +downstreamnt
atgaatccgcggcaggggtattccctcagcggatactacacccatccatttcaaggctat
gagcacagacagctcaggtaccagcagcctgggccaggatcttcccccagtagtttcctg
cttaagcaaatagaatttctcaaggggcagctcccagaagcaccggtgattggaaagcag
acaccgtcactgccaccttccctcccaggactccggccaaggtttccagtactacttgcc
tccagtaccagaggcaggcaagtggacatcaggggtgtccccaggggcgtgcatctcaga
agtcaggggctccagagagggttccagcatccttcaccacgtggcaggagtctgccacag
agaggtgttgattgcctttcctcacatttccaggaactgagtatctaccaagatcaggaa
caaaggatcttaaagttcctggaagagcttggggaagggaaggccaccacagcacatgat
ctgtctgggaaacttgggactccgaagaaagaaatcaatcgagttttatactccctggca
aagaagggcaagctacagaaagaggcaggaacaccccctttgtggaaaatcgcggtctcc
actcaggcttggaaccagcacagcggagtggtaagaccagacggtcatagccaaggagcc
ccaaactcagacccgagtttggaaccggaagacagaaactccacatctgtctcagaagat
cttcttgagccttttattgcagtctcagctcaggcttggaaccagcacagcggagtggta
agaccagacagtcatagccaaggatccccaaactcagacccaggtttggaacctgaagac
agcaactccacatctgccttggaagatcctcttgagtttttagacatggccgagatcaag
gagaaaatctgcgactatctcttcaatgtgtctgactcctctgccctgaatttggctaaa
aatattggccttaccaaggcccgagatataaatgctgtgctaattgacatggaaaggcag
ggggatgtctatagacaagggacaacccctcccatatggcatttgacagacaagaagcga
gagaggatgcaaatcaagagaaatacgaacagtgttcctgaaaccgctccagctgcaatc
cctgagaccaaaagaaacgcagagttcctcacctgtaatatacccacatcaaatgcctca
aataacatggtaaccacagaaaaagtggagaatgggcaggaacctgtcataaagttagaa
aacaggcaagaggccagaccagaaccagcaagactgaaaccacctgttcattacaatggc
ccctcaaaagcagggtatgttgactttgaaaatggccagtgggccacagatgacatccca
gatgacttgaatagtatccgcgcagcaccaggtgagtttcgagccatcatggagatgccc
tccttctacagtcatggcttgccacggtgttcaccctacaagaaactgacagagtgccag
ctgaagaaccccatcagcgggctgttagaatatgcccagttcgctagtcaaacctgtgag
ttcaacatgatagagcagagtggaccaccccatgaacctcgatttaaattccaggttgtc
atcaatggccgagagtttcccccagctgaagctggaagcaagaaagtggccaagcaggat
gcagctatgaaagccatgacaattctgctagaggaagccaaagccaaggacagtggaaaa
tcagaagaatcatcccactattccacagagaaagaatcagagaagactgcagagtcccag
acccccaccccttcagccacatccttcttttctgggaagagccccgtcaccacactgctt
gagtgtatgcacaaattggggaactcctgcgaattccgtctcctgtccaaagaaggccct
gcccatgaacccaagttccaatactgtgttgcagtgggagcccaaactttccccagtgtg
agtgctcccagcaagaaagtggcaaagcagatggccgcagaggaagccatgaaggccctg
catggggaggcgaccaactccatggcttctgataaccagcctgaaggtatgatctcagag
tcacttgataacttggaatccatgatgcccaacaaggtcaggaagattggcgagctcgtg
agatacctgaacaccaaccctgtgggtggccttttggagtacgcccgctcccatggcttt
gctgctgaattcaagttggtcgaccagtccggacctcctcacgagcccaagttcgtttac
caagcaaaagttgggggtcgctggttcccagccgtctgcgcacacagcaagaagcaaggc
aagcaggaagcagcagatgcggctctccgtgtcttgattggggagaacgagaaggcagaa
cgcatgggtttcacagaggtaaccccagtgacaggggccagtctcagaagaactatgctc
ctcctctcaaggtccccagaagcacagccaaagacactccctctcactggcagcaccttc
catgaccagatagccatgctgagccaccggtgcttcaacactctgactaacagcttccag
ccctccttgctcggccgcaagattctggccgccatcattatgaaaaaagactctgaggac
atgggtgtcgtcgtcagcttgggaacagggaatcgctgtgtgaaaggagattctctcagc
ctaaaaggagaaactgtcaatgactgccatgcagaaataatctcccggagaggcttcatc
aggtttctctacagtgagttaatgaaatacaactcccagactgcgaaggatagtatattt
gaacctgctaagggaggagaaaagctccaaataaaaaagactgtgtcattccatctgtat
atcagcactgctccgtgtggagatggcgccctctttgacaagtcctgcagcgaccgtgct
atggaaagcacagaatcccgccactaccctgtcttcgagaatcccaaacaaggaaagctc
cgcaccaaggtggagaacggagaaggcacaatccctgtggaatccagtgacattgtgcct
acgtgggatggcattcggctcggggagagactccgtaccatgtcctgtagtgacaaaatc
ctacgctggaacgtgctgggcctgcaaggggcactgttgacccacttcctgcagcccatt
tatctcaaatctgtcacattgggttaccttttcagccaagggcatctgacccgtgctatt
tgctgtcgtgtgacaagagatgggagtgcatttgaggatggactacgacatccctttatt
gtcaaccaccccaaggttggcagagtcagcatatatgattccaaaaggcaatccgggaag
actaaggagacaagcgtcaactggtgtctggctgatggctatgacctggagatcctggac
ggtaccagaggcactgtggatgggccacggaatgaattgtcccgggtctccaaaaagaac
atttttcttctatttaagaagctctgctccttccgttaccgcagggatctactgagactc
tcctatggtgaggccaagaaagctgcccgtgactacgagacggccaagaactacttcaaa
aaaggcctgaaggatatgggctatgggaactggattagcaaaccccaggaggaaaagaac
ttttatctctgcccagtatag

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