KEGG   ORTHOLOGY: K12968
Entry
K12968                      KO                                     
Symbol
ADAR, ADAR1
Name
double-stranded RNA-specific adenosine deaminase [EC:3.5.4.37]
Pathway
map04623  Cytosolic DNA-sensing pathway
map05162  Measles
map05164  Influenza A
map05171  Coronavirus disease - COVID-19
Disease
H00290  Aicardi-Goutieres syndrome
H00880  Dyschromatosis symmetrica hereditaria
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09151 Immune system
   04623 Cytosolic DNA-sensing pathway
    K12968  ADAR, ADAR1; double-stranded RNA-specific adenosine deaminase
 09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K12968  ADAR, ADAR1; double-stranded RNA-specific adenosine deaminase
   05164 Influenza A
    K12968  ADAR, ADAR1; double-stranded RNA-specific adenosine deaminase
   05162 Measles
    K12968  ADAR, ADAR1; double-stranded RNA-specific adenosine deaminase
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03041 Spliceosome
    K12968  ADAR, ADAR1; double-stranded RNA-specific adenosine deaminase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.4  In cyclic amidines
    3.5.4.37  double-stranded RNA adenine deaminase
     K12968  ADAR, ADAR1; double-stranded RNA-specific adenosine deaminase
Spliceosome [BR:ko03041]
 Other splicing related proteins
  Spliceosome associated proteins (SAPs)
   RNA binding proteins (RBPs)
    K12968  ADAR, ADAR1; double-stranded RNA-specific adenosine deaminase
Other DBs
GO: 0003726
Genes
HSA: 103(ADAR)
PTR: 457349(ADAR)
PPS: 100988581(ADAR)
GGO: 101134621(ADAR)
PON: 100457633(ADAR)
NLE: 100607902(ADAR)
MCC: 718759(ADAR)
MCF: 101926284(ADAR)
CSAB: 103223917(ADAR)
CATY: 105593498(ADAR)
PANU: 101026850(ADAR)
TGE: 112618205(ADAR)
RRO: 104663489(ADAR)
TFN: 117075904(ADAR)
PTEH: 111543727(ADAR)
CJC: 100386367(ADAR)
SBQ: 101031414(ADAR)
CSYR: 103250006(ADAR)
MMUR: 105873198(ADAR)
OGA: 100941374(ADAR)
MMU: 56417(Adar)
MCAL: 110291799(Adar)
MPAH: 110320021(Adar)
RNO: 81635(Adar)
MCOC: 116093186(Adar)
MUN: 110562048(Adar)
CGE: 100760578(Adar)
PLEU: 114707958(Adar)
NGI: 103751329(Adar)
HGL: 101722209(Adar)
CPOC: 100731315(Adar)
CCAN: 109688036(Adar)
DORD: 105984887(Adar)
DSP: 122109246(Adar)
NCAR: 124983355
OCU: 100346984(ADAR)
OPI: 101527981(ADAR)
TUP: 102485185(ADAR)
CFA: 100855668(ADAR)
VVP: 112918890(ADAR)
VLG: 121484976(ADAR)
AML: 100470274(ADAR)
UMR: 103668714(ADAR)
UAH: 113245303(ADAR)
UAR: 123783391(ADAR)
ELK: 111138988
LLV: 125086092
MPUF: 101675332(ADAR)
ORO: 101367365(ADAR)
EJU: 114198712(ADAR)
ZCA: 113932110(ADAR)
MLX: 118013854(ADAR)
FCA: 101084681(ADAR)
PYU: 121015666(ADAR)
PBG: 122476118(ADAR)
PPAD: 109256299(ADAR)
AJU: 106988378(ADAR)
HHV: 120221535(ADAR)
BTA: 505134(ADAR)
BOM: 102267031(ADAR)
BBUB: 102413801(ADAR)
CHX: 102172585(ADAR)
ODA: 120855758(ADAR)
CCAD: 122432929(ADAR)
SSC: 100523784(ADAR)
CFR: 102512737(ADAR)
CBAI: 105068180(ADAR)
CDK: 105089080(ADAR)
VPC: 102527263(ADAR)
BACU: 103018582(ADAR)
LVE: 103077270(ADAR)
OOR: 101278697(ADAR)
DLE: 111166955(ADAR)
PCAD: 102979811(ADAR)
PSIU: 116750910(ADAR)
ECB: 100056984(ADAR)
EPZ: 103555415(ADAR)
EAI: 106828524(ADAR)
MYB: 102242753(ADAR)
MYD: 102754391(ADAR)
MMYO: 118672760(ADAR)
MLF: 102433169(ADAR)
MNA: 107543857(ADAR)
PKL: 118721102(ADAR)
DRO: 112316695(ADAR)
SHON: 118990185(ADAR)
AJM: 119061768(ADAR)
PDIC: 114488810(ADAR)
PHAS: 123804313(ADAR)
MMF: 118637050(ADAR)
RFQ: 117014567(ADAR)
PGIG: 120592241(ADAR)
PVP: 105296385(ADAR)
RAY: 107504718(ADAR)
MJV: 108393907(ADAR)
TOD: 119237217(ADAR)
SARA: 101553112(ADAR)
TMU: 101360020
DNM: 101424153(ADAR)
MDO: 100020840(ADAR)
GAS: 123247778(ADAR)
SHR: 100925968(ADAR)
PCW: 110211972(ADAR)
OAA: 103167888(ADAR)
GGA: 769675(ADAR)
PCOC: 116237321(ADAR)
MGP: 100541796(ADAR)
CJO: 107324489(ADAR)
NMEL: 110391260(ADAR)
APLA: 101796198(ADAR)
ACYG: 106048529(ADAR)
AFUL: 116499616(ADAR)
TGU: 100220215(ADAR)
LSR: 110471526(ADAR)
SCAN: 103823962(ADAR)
PMOA: 120498974(ADAR)
OTC: 121332158(ADAR)
PRUF: 121352167(ADAR)
GFR: 102033970(ADAR)
FAB: 101806137(ADAR)
PHI: 102105960(ADAR)
PMAJ: 107214561(ADAR)
CCAE: 111939463(ADAR)
ETL: 114068438(ADAR)
ZAB: 102064605(ADAR)
FPG: 101910869(ADAR)
FCH: 102049629(ADAR)
CLV: 102086506(ADAR)
EGZ: 104127874(ADAR)
NNI: 104012041(ADAR)
ACUN: 113490858(ADAR)
TALA: 104365296(ADAR)
PADL: 103920515(ADAR)
ACHC: 115346426(ADAR)
AAM: 106483717(ADAR)
AROW: 112973224(ADAR)
NPD: 112955220(ADAR)
DNE: 112995108(ADAR)
ASN: 102377665(ADAR)
AMJ: 102575445(ADAR)
CPOO: 109324760(ADAR)
GGN: 109303498(ADAR)
PSS: 102449470(ADAR)
CMY: 102941128(ADAR)
CPIC: 101936755(ADAR)
TST: 117888546(ADAR)
CABI: 116830121(ADAR)
MRV: 120390168(ADAR)
ACS: 103281753
PVT: 110081003(ADAR)
SUND: 121915309(ADAR)
PBI: 103050667(ADAR)
PMUR: 107285169(ADAR)
TSR: 106546970(ADAR)
PGUT: 117657417(ADAR)
VKO: 123032540(ADAR)
PMUA: 114586089(ADAR)
ZVI: 118075835(ADAR)
GJA: 107117082(ADAR)
XLA: 394279(adar-a) 397992(adar.S)
XTR: 100493195(adar)
NPR: 108798342(ADAR)
RTEM: 120920674(ADAR)
BBUF: 120981415(ADAR)
BGAR: 122921756(ADAR)
DRE: 58119(adar)
SANH: 107657642
SGH: 107582078
CCAR: 109069003
PPRM: 120484300(adar)
MAMB: 125242935(adar)
IPU: 108265537(adar)
PHYP: 113545404(adar)
SMEO: 124384211(adar)
TFD: 113646833(adar)
AMEX: 103023414(adar)
EEE: 113591712(adar)
TRU: 101073967(adar)
LCO: 104922500(adar)
NCC: 104958853(adar)
CGOB: 115020800(adar)
ELY: 117265724(adar)
PLEP: 121945375(adar)
SLUC: 116049564(adar)
ECRA: 117946697(adar)
PFLV: 114556855(adar)
GAT: 120810483(adar)
PPUG: 119197717(adar)
MSAM: 119897576(adar)
CUD: 121513229(adar)
ALAT: 119005863(adar)
MZE: 101475397(adar)
ONL: 100707103(adar)
OAU: 116315701(adar)
OLA: 101155879(adar)
OML: 112143394(adar)
XMA: 102217978(adar)
XCO: 114141750(adar)
XHE: 116717193(adar)
PRET: 103478179(adar)
PFOR: 103140790(adar)
PLAI: 106962090(adar)
PMEI: 106930146(adar)
GAF: 122830951(adar)
CVG: 107088416(adar)
CTUL: 119786711(adar)
GMU: 124866009(adar)
NFU: 107374479(adar)
KMR: 108241070(adar)
ALIM: 106517188(adar)
NWH: 119409734(adar) 119410066
AOCE: 111582754(adar)
CSEM: 103388211(adar)
POV: 109633429(adar)
SSEN: 122774816(adar)
HHIP: 117776470(adar)
LCF: 108885934(adar)
SDU: 111230122(adar)
SLAL: 111656978(adar)
XGL: 120784244(adar)
HCQ: 109521078(adar)
BPEC: 110162987
MALB: 109964118(adar)
BSPL: 114843501(adar)
SASA: 106605901(adar)
OMY: 110520838(adar) 110534250
ONE: 115124133
SALP: 112075075
ELS: 105024448(adar)
SFM: 108925759(adar)
PKI: 111840888(adar)
AANG: 118224938(adar)
PSPA: 121306932(adar)
LCM: 102360746(ADAR)
RTP: 109912767(adar)
BBEL: 109468498
CIN: 100183336
SPU: 584058
PCLA: 123770612
RSAN: 119405262
RMP: 119180667
VJA: 111272658
SDM: 118189760
CEL: CELE_T20H4.4(adr-2)
PMAX: 117334379
MMER: 123531101
NVE: 5508360
ATEN: 116286315
 » show all
Reference
  Authors
Herbert A, Wagner S, Nickerson JA
  Title
Induction of protein translation by ADAR1 within living cell nuclei is not dependent on RNA editing.
  Journal
Mol Cell 10:1235-46 (2002)
DOI:10.1016/S1097-2765(02)00737-2
Reference
PMID:7972084
  Authors
Kim U, Wang Y, Sanford T, Zeng Y, Nishikura K
  Title
Molecular cloning of cDNA for double-stranded RNA adenosine deaminase, a candidate enzyme for nuclear RNA editing.
  Journal
Proc Natl Acad Sci U S A 91:11457-61 (1994)
DOI:10.1073/pnas.91.24.11457
  Sequence
[hsa:103]
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