Homo sapiens (human): 143471
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Entry
143471 CDS
T01001
Symbol
PSMA8, PSMA7L
Name
(RefSeq) proteasome 20S subunit alpha 8
KO
K02731
20S proteasome subunit alpha 4 [EC:
3.4.25.1
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa03050
Proteasome
hsa05010
Alzheimer disease
hsa05012
Parkinson disease
hsa05014
Amyotrophic lateral sclerosis
hsa05016
Huntington disease
hsa05017
Spinocerebellar ataxia
hsa05020
Prion disease
hsa05022
Pathways of neurodegeneration - multiple diseases
Network
nt06460
Alzheimer disease
nt06461
Huntington disease
nt06463
Parkinson disease
nt06464
Amyotrophic lateral sclerosis
nt06465
Prion disease
nt06466
Pathways of neurodegeneration
Element
N01029
26S proteasome-mediated protein degradation
N01030
Mutation-caused aberrant SNCA to 26S proteasome-mediated protein degradation
N01060
Mutation-caused aberrant Abeta to 26S proteasome-mediated protein degradation
N01061
Mutation-caused aberrant Htt to 26S proteasome-mediated protein degradation
N01144
Mutation-caused aberrant SOD1 to 26S proteasome-mediated protein degradation
N01145
Mutation-inactivated VCP to 26S proteasome-mediated protein degradation
N01146
Mutation-inactivated UBQLN2 to 26S proteasome-mediated protein degradation
N01197
Scrapie conformation PrPSc to 26S proteasome-mediated protein degradation
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
03050 Proteasome
143471 (PSMA8)
09160 Human Diseases
09164 Neurodegenerative disease
05010 Alzheimer disease
143471 (PSMA8)
05012 Parkinson disease
143471 (PSMA8)
05014 Amyotrophic lateral sclerosis
143471 (PSMA8)
05016 Huntington disease
143471 (PSMA8)
05017 Spinocerebellar ataxia
143471 (PSMA8)
05020 Prion disease
143471 (PSMA8)
05022 Pathways of neurodegeneration - multiple diseases
143471 (PSMA8)
09180 Brite Hierarchies
09181 Protein families: metabolism
01002 Peptidases and inhibitors [BR:
hsa01002
]
143471 (PSMA8)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
hsa04131
]
143471 (PSMA8)
03051 Proteasome [BR:
hsa03051
]
143471 (PSMA8)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.4 Acting on peptide bonds (peptidases)
3.4.25 Threonine endopeptidases
3.4.25.1 proteasome endopeptidase complex
143471 (PSMA8)
Peptidases and inhibitors [BR:
hsa01002
]
Threonine peptidases
Family T1: proteasome family
143471 (PSMA8)
Membrane trafficking [BR:
hsa04131
]
Endosome - Lysosome transport
Rab GTPases and associated proteins
Rab associated proteins
143471 (PSMA8)
Proteasome [BR:
hsa03051
]
Eukaryotic proteasome
Core particles (20S proteasome)
alpha type subunits
143471 (PSMA8)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Proteasome
Proteasome_A_N
Myb_DNA-bind_5
DUF4372
Motif
Other DBs
NCBI-GeneID:
143471
NCBI-ProteinID:
NP_653263
OMIM:
617841
HGNC:
22985
Ensembl:
ENSG00000154611
UniProt:
Q8TAA3
LinkDB
All DBs
Position
18:26133869..26193355
Genome browser
AA seq
256 aa
AA seq
DB search
MASRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERT
VRKICALDDHVCMAFAVLTIFIGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIA
TLKQKYTQSNGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFL
EKNYTEDAIASDSEAIKLAIKALLEVVQSGGKNIELAIIRRNQPLKMFSAKEVELYVTEI
EKEKEEAEKKKSKKSV
NT seq
771 nt
NT seq
+upstream
nt +downstream
nt
atggcgtctcgatatgacagggcgatcactgtcttctccccagacggacacctttttcaa
gttgaatatgcccaggaagcggtgaagaaaggatccaccgcggtcggaattcgaggtacc
aatatagttgttcttggggtagaaaaaaaatctgttgccaagcttcaagatgaaagaact
gtgaggaaaatttgtgcccttgatgaccatgtctgcatggcttttgcagttttgacaatt
tttataggacttactgctgatgctagagtagtaataaacagagcccgtgtggagtgccag
agccataagcttacggttgaggacccagtcactgtagaatacataactcgcttcatagca
actttaaagcagaaatatacccaaagcaatggacgaagaccttttggtatttctgcctta
attgtaggttttgatgatgatggtatctcaagattgtatcagacagatccttctggtact
tatcatgcttggaaggcaaatgcaataggccgaagtgctaaaactgttcgagaatttcta
gaaaagaattacacagaagatgccatagcaagtgacagtgaagctatcaagttagcaata
aaagctttgctagaagttgtccagtctggtggaaaaaacattgaacttgctataataaga
agaaatcaacctttgaagatgtttagtgcaaaagaagttgaattatatgtaactgaaata
gaaaaggaaaaggaagaagcagagaagaaaaaatcaaagaaatctgtctaa
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