 | | NETWORK: N01197 | |
| Entry |
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| Name |
Scrapie conformation PrPSc to 26S proteasome-mediated protein degradation
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| Definition |
PRNP* -| 26S |
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| Expanded |
5621v1 -| (5687+5683+5685+5688+143471+5686+5682+5684+5694+5695+5691+5690+5693+5689+5692+5701+5700+5704+5706+5702+5705+5708+5707+5709+5715+5718+5717+9861+5713+5719+5710+10213+5714+11047+7979) |
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| Class |
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| Type |
Variant
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| Pathway |
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| Disease |
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| Gene |
| 5687 | PSMA6; proteasome 20S subunit alpha 6 |
| 5683 | PSMA2; proteasome 20S subunit alpha 2 |
| 5685 | PSMA4; proteasome 20S subunit alpha 4 |
| 5688 | PSMA7; proteasome 20S subunit alpha 7 |
| 143471 | PSMA8; proteasome 20S subunit alpha 8 |
| 5686 | PSMA5; proteasome 20S subunit alpha 5 |
| 5682 | PSMA1; proteasome 20S subunit alpha 1 |
| 5684 | PSMA3; proteasome 20S subunit alpha 3 |
| 5694 | PSMB6; proteasome 20S subunit beta 6 |
| 5695 | PSMB7; proteasome 20S subunit beta 7 |
| 5691 | PSMB3; proteasome 20S subunit beta 3 |
| 5690 | PSMB2; proteasome 20S subunit beta 2 |
| 5693 | PSMB5; proteasome 20S subunit beta 5 |
| 5689 | PSMB1; proteasome 20S subunit beta 1 |
| 5692 | PSMB4; proteasome 20S subunit beta 4 |
| 5701 | PSMC2; proteasome 26S subunit, ATPase 2 |
| 5700 | PSMC1; proteasome 26S subunit, ATPase 1 |
| 5704 | PSMC4; proteasome 26S subunit, ATPase 4 |
| 5706 | PSMC6; proteasome 26S subunit, ATPase 6 |
| 5702 | PSMC3; proteasome 26S subunit, ATPase 3 |
| 5705 | PSMC5; proteasome 26S subunit, ATPase 5 |
| 5708 | PSMD2; proteasome 26S subunit, non-ATPase 2 |
| 5707 | PSMD1; proteasome 26S subunit, non-ATPase 1 |
| 5709 | PSMD3; proteasome 26S subunit, non-ATPase 3 |
| 5715 | PSMD9; proteasome 26S subunit, non-ATPase 9 |
| 5718 | PSMD12; proteasome 26S subunit, non-ATPase 12 |
| 5717 | PSMD11; proteasome 26S subunit, non-ATPase 11 |
| 9861 | PSMD6; proteasome 26S subunit, non-ATPase 6 |
| 5713 | PSMD7; proteasome 26S subunit, non-ATPase 7 |
| 5719 | PSMD13; proteasome 26S subunit, non-ATPase 13 |
| 5710 | PSMD4; proteasome 26S subunit, non-ATPase 4 |
| 10213 | PSMD14; proteasome 26S subunit, non-ATPase 14 |
| 5714 | PSMD8; proteasome 26S subunit, non-ATPase 8 |
| 11047 | ADRM1; adhesion regulating molecule 1 |
| 7979 | SEM1; SEM1 26S proteasome complex subunit |
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| Variant |
5621v1 (PRNP*) PRNP scrapie conformation
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| Reference |
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| Authors |
Kristiansen M, Deriziotis P, Dimcheff DE, Jackson GS, Ovaa H, Naumann H, Clarke AR, van Leeuwen FW, Menendez-Benito V, Dantuma NP, Portis JL, Collinge J, Tabrizi SJ |
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| Title |
Disease-associated prion protein oligomers inhibit the 26S proteasome. |
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| Journal |
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| Reference |
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| Authors |
Andre R, Tabrizi SJ |
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| Title |
Misfolded PrP and a novel mechanism of proteasome inhibition. |
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| Journal |
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| Reference |
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| Authors |
Deriziotis P, Andre R, Smith DM, Goold R, Kinghorn KJ, Kristiansen M, Nathan JA, Rosenzweig R, Krutauz D, Glickman MH, Collinge J, Goldberg AL, Tabrizi SJ |
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| Title |
Misfolded PrP impairs the UPS by interaction with the 20S proteasome and inhibition of substrate entry. |
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| Journal |
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| Reference |
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| Authors |
Zhu T, Hayat Khan S, Zhao D, Yang L |
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| Title |
Regulation of proteasomes in prion disease. |
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| Journal |
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| LinkDB |
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