KEGG   NETWORK: N01060
Entry
N01060                      Network                                

Name
Mutation-caused aberrant Abeta to 26S proteasome-mediated protein degradation
Definition
APP* -> Abeta -| 26S
  Expanded
351v1 -> (C16515,C16514) -| (5687+5683+5685+5688+143471+5686+5682+5684+5694+5695+5691+5690+5693+5689+5692+5701+5700+5704+5706+5702+5705+5708+5707+5709+5715+5718+5717+9861+5713+5719+5710+10213+5714+11047+7979)
Class
nt06420 Ubiquitin-proteasome system
nt06460 Alzheimer disease
Type
Variant
Pathway
hsa05010  Alzheimer disease
Disease
H00056  Alzheimer disease
Gene
351  APP; amyloid beta precursor protein
5687  PSMA6; proteasome 20S subunit alpha 6
5683  PSMA2; proteasome 20S subunit alpha 2
5685  PSMA4; proteasome 20S subunit alpha 4
5688  PSMA7; proteasome 20S subunit alpha 7
143471  PSMA8; proteasome 20S subunit alpha 8
5686  PSMA5; proteasome 20S subunit alpha 5
5682  PSMA1; proteasome 20S subunit alpha 1
5684  PSMA3; proteasome 20S subunit alpha 3
5694  PSMB6; proteasome 20S subunit beta 6
5695  PSMB7; proteasome 20S subunit beta 7
5691  PSMB3; proteasome 20S subunit beta 3
5690  PSMB2; proteasome 20S subunit beta 2
5693  PSMB5; proteasome 20S subunit beta 5
5689  PSMB1; proteasome 20S subunit beta 1
5692  PSMB4; proteasome 20S subunit beta 4
5701  PSMC2; proteasome 26S subunit, ATPase 2
5700  PSMC1; proteasome 26S subunit, ATPase 1
5704  PSMC4; proteasome 26S subunit, ATPase 4
5706  PSMC6; proteasome 26S subunit, ATPase 6
5702  PSMC3; proteasome 26S subunit, ATPase 3
5705  PSMC5; proteasome 26S subunit, ATPase 5
5708  PSMD2; proteasome 26S subunit, non-ATPase 2
5707  PSMD1; proteasome 26S subunit, non-ATPase 1
5709  PSMD3; proteasome 26S subunit, non-ATPase 3
5715  PSMD9; proteasome 26S subunit, non-ATPase 9
5718  PSMD12; proteasome 26S subunit, non-ATPase 12
5717  PSMD11; proteasome 26S subunit, non-ATPase 11
9861  PSMD6; proteasome 26S subunit, non-ATPase 6
5713  PSMD7; proteasome 26S subunit, non-ATPase 7
5719  PSMD13; proteasome 26S subunit, non-ATPase 13
5710  PSMD4; proteasome 26S subunit, non-ATPase 4
10213  PSMD14; proteasome 26S subunit, non-ATPase 14
5714  PSMD8; proteasome 26S subunit, non-ATPase 8
11047  ADRM1; adhesion regulating molecule 1
7979  SEM1; SEM1 26S proteasome complex subunit
Variant
351v1 (APP*)  APP mutation
Metabolite
C16515  Beta-amyloid protein 42
C16514  Beta-amyloid protein 40
Reference
  Authors
Thibaudeau TA, Anderson RT, Smith DM
  Title
A common mechanism of proteasome impairment by neurodegenerative disease-associated oligomers.
  Journal
Nat Commun 9:1097 (2018)
DOI:10.1038/s41467-018-03509-0
Reference
  Authors
Smith DM
  Title
Could a Common Mechanism of Protein Degradation Impairment Underlie Many Neurodegenerative Diseases?
  Journal
J Exp Neurosci 12:1179069518794675 (2018)
DOI:10.1177/1179069518794675
Reference
  Authors
Tramutola A, Di Domenico F, Barone E, Perluigi M, Butterfield DA
  Title
It Is All about (U)biquitin: Role of Altered Ubiquitin-Proteasome System and UCHL1 in Alzheimer Disease.
  Journal
Oxid Med Cell Longev 2016:2756068 (2016)
DOI:10.1155/2016/2756068
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